Peptide LibraryInsulin sensitivity, glucose control or body weight
Insufficient information to assessSurrogate outcome · 1 study · 0 participants
Not enough evidence to tell
There are no published human results on whether MOTS-c improves insulin sensitivity, blood sugar control or body weight in people with obesity, insulin resistance or diabetes. One placebo-controlled trial is underway but has not reported findings. The evidence is insufficient to say whether MOTS-c helps, and this is not evidence that it does not work.
What the research measured: One registered placebo-controlled trial of MOTS-c in adults with prediabetes and overweight/obesity targets insulin sensitivity. It is recruiting and has no reported results, so no effect on insulin sensitivity, glucose control or body weight has been measured.
What remains unknown: Whether MOTS-c changes insulin sensitivity, glucose control or body weight in humans. Its effects in people with type 2 diabetes. Effects on patient-important outcomes and longer-term outcomes. Its safety and adverse effects. Trial design details such as randomization and blinding.
Reviewers’ note: The only eligible study is a registered, recruiting trial with no posted results. Without any outcome data, no GRADE certainty rating can be assigned.
How the certainty was judged
| Domain | Judgment | Why |
|---|---|---|
| Starting level | — | |
| Risk of bias | — | Randomization, allocation concealment and blinding are not described in the registry record, and outcomes are not prespecified in the stored fields; no results exist to appraise. |
| Inconsistency | — | Only one registered study is eligible, and it has no reported results, so consistency cannot be assessed. |
| Indirectness | — | Population (prediabetes, overweight/obesity, insulin resistance), MOTS-c versus placebo and insulin sensitivity outcome match the question. |
| Imprecision | — | No outcome data or effect estimates have been reported; the trial is still recruiting with an estimated planned enrollment of 120. |
| Publication bias | — | A registered trial that is still recruiting has no posted results, and no published data exist for it among the included studies. |
Included studies
Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · GRADE (handbook, 2013) · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.