Peptide Library

Human study PLS-00063

Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes.

Cross-sectional study · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes.primary · Biochimica et biophysica acta. General subjects · 2021-08-20 · PMID 34419510 · DOI

Design and participants

Design
Cross-sectional study
Population
Adults without overt type 2 diabetes or cardiovascular disease: 125 Chinese participants (91 male, 34 female) plus an additional 34 European Caucasian females who underwent MRI/S.
Conditions
metabolic syndrome, adiposity, liver fat
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported
Funding
Research Support, Non-U.S. Gov't (publication type); funder not named

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety, and how safety was monitored isn’t described.

    The authors concluded (paraphrased): Without overt type 2 diabetes, metabolic syndrome components and android fat, especially liver fat, were positively associated with plasma MOTS-c and SHLP2. The authors suggest that mitochondrial peptides are part of a hepatic-centric hormetic response.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: MOTS-c was measured as an endogenous biomarker, not administered, so the study gives no evidence on effects of giving MOTS-c.
    • confounding: The cross-sectional associations cannot establish causality or direction between fat depots and plasma peptide levels.
    • abstract only: Only the abstract is available in the record, so methods and full results cannot be appraised.
    • inappropriate endpoint: The study measured endogenous peptide levels as biomarkers. MOTS-c was not administered, so it gives no evidence on the effects or safety of giving it.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • author_conclusion: PMID 34419510, abstract (final two sentences) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 34419510, abstract (sentence 3) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 34419510, abstract (sentences 3-5) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).