Peptide LibraryHuman evidence quality
MOTS-C: what the human research shows
Evidence overview
Research volume and reviewed human evidence are different numbers, kept apart.
Indexed publications
211
Research snapshot 2026.1.1
Human clinical publications
60
PubMed records classified as human research
Distinct human studies reviewed
1
of 62 identified
Randomized controlled studies
0
among reviewed studies
Studies with reported results
0
Registered, no results available
1
Unpublished is not negative
Study results assessed for risk of bias
0
Outcomes with a certainty assessment
2
Claims evaluated
Claims are things to investigate, never established benefits. Evidence for one outcome doesn’t carry over to another.
| Claim being evaluated | Eligible human studies | Certainty by outcome |
|---|---|---|
| Improves metabolic health | 1 |
|
| Is safe for human administrationSafety | 0 |
|
Human studies
Each distinct study once, however many papers, abstracts or registrations describe it.
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/ObesityOther design · Not reported participants · first reported 2026 · automated, not human-reviewed
Population: Adults with prediabetes, insulin resistance and overweight/obesity (registered conditions).
Full study record (PLS-00249)Records reviewed and excluded (61)
- Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?: other
- Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.: other
- MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction.: other
- Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study.: other
- MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study.: other
- The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study.: other
- Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study.: other
- Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss.: other
- Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients.: other
- The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients: A Multicenter Cohort Study.: other
- Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis.: other
- Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.: other
- AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.: other
- Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.: other
- Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea.: other
- Circulating levels of MOTS-c in patients with breast cancer treated with metformin.: wrong compound
- Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.: other
- Circulating mitochondrial biomarkers in acute coronary syndrome.: other
- MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study.: other
- Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?: other
- MOTS-c as a Potential Diagnostic-prognostic Biomarker for Myocardial Infarction.: other
- Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization.: wrong compound
- Evaluation of vascular peroxidase 1, humanin, MOTS-c and miR-200c expression levels in untreated preeclampsia patients.: other
- Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.: wrong compound
- Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea.: other
- Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement.: other
- Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes.: other
- Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure.: wrong compound
- The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.: other
- Effects of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes.: wrong compound
- Mitochondrial dysfunction is associated with cognitive impairment in adults with OSA without dementia.: other
- Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.: wrong compound
- MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake-A Preliminary Study.: wrong compound
- The relationship of circulating MOTS-c level with liver fibrosis and metabolic components in patients with metabolic dysfunction-associated fatty liver disease.: other
- A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.: other
- Evaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCI.: other
- Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function.: other
- Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.: other
- Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.: other
- Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.: other
- Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.: other
- Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls.: other
- Serum MOTS-c levels remain unchanged in patients with preeclampsia.: other
- MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease.: other
- Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction.: other
- Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals.: other
- Adropin and MOTS-c as new peptides: Do levels change in neurodegenerative diseases and ischemic stroke?: other
- Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.: wrong compound
- The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes.: other
- Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation.: other
- Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.: other
- Changes in MOTS-c Level in the Blood of Pregnant Women with Metabolic Disorders.: other
- A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.: wrong compound
- Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.: wrong compound
- Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.: other
- Prediction of Post-Acute-Sequelae of COVID-19 by Cargo Protein Biomarkers of Blood Total Extracellular Vesicles in Acute COVID-19.: other
- Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance.: other
- The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults.: wrong compound
- Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects.: other
- SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19.: other
- Associations of Serum MOTS-c with Exercise Capacity and Antioxidant Markers in Young Males: A Cross-Sectional Study.: wrong compound
Why the counts differ
Publications, studies and registrations are different units.
These numbers count different things. The research snapshot 2026.1.1 counts 60 human clinical publications: PubMed records, classified by publication type. Here, each reviewed study is counted once (1 in all), however many reports describe it (61 PubMed records, 1 registration, 0 other reports such as meeting abstracts outside PubMed).
| Study | Source record | Role |
|---|---|---|
| PLS-00037 (excluded) | PMID 41945630Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome? | primary |
| PLS-00038 (excluded) | PMID 41680431Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction. | primary |
| PLS-00039 (excluded) | PMID 41004666MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction. | primary |
| PLS-00040 (excluded) | PMID 42278864Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study. | primary |
| PLS-00041 (excluded) | PMID 42126770MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study. | primary |
| PLS-00042 (excluded) | PMID 42072458The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study. | primary |
| PLS-00043 (excluded) | PMID 39201408Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study. | primary |
| PLS-00044 (excluded) | PMID 41551324Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss. | primary |
| PLS-00045 (excluded) | PMID 42166398Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients. | primary |
| PLS-00046 (excluded) | PMID 39111290The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients: A Multicenter Cohort Study. | primary |
| PLS-00047 (excluded) | PMID 41479490Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis. | primary |
| PLS-00048 (excluded) | PMID 41368821Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study. | primary |
| PLS-00049 (excluded) | PMID 42650220AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition. | primary |
| PLS-00050 (excluded) | PMID 41303353Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease. | primary |
| PLS-00051 (excluded) | PMID 40538389Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea. | primary |
| PLS-00052 (excluded) | PMID 36490309Circulating levels of MOTS-c in patients with breast cancer treated with metformin. | primary |
| PLS-00053 (excluded) | PMID 40768089Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification. | primary |
| PLS-00054 (excluded) | PMID 40443515Circulating mitochondrial biomarkers in acute coronary syndrome. | primary |
| PLS-00055 (excluded) | PMID 40005438MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study. | primary |
| PLS-00056 (excluded) | PMID 39711006Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease? | primary |
| PLS-00057 (excluded) | PMID 40353474MOTS-c as a Potential Diagnostic-prognostic Biomarker for Myocardial Infarction. | primary |
| PLS-00058 (excluded) | PMID 40674654Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization. | primary |
| PLS-00059 (excluded) | PMID 39704971Evaluation of vascular peroxidase 1, humanin, MOTS-c and miR-200c expression levels in untreated preeclampsia patients. | primary |
| PLS-00060 (excluded) | PMID 34413391Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. | primary |
| PLS-00061 (excluded) | PMID 33394327Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea. | primary |
| PLS-00062 (excluded) | PMID 40104672Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement. | primary |
| PLS-00063 (excluded) | PMID 34419510Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes. | primary |
| PLS-00064 (excluded) | PMID 39182552Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure. | primary |
| PLS-00065 (excluded) | PMID 34728329The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance. | primary |
| PLS-00066 (excluded) | PMID 40008510Effects of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes. | primary |
| PLS-00067 (excluded) | PMID 38704871Mitochondrial dysfunction is associated with cognitive impairment in adults with OSA without dementia. | primary |
| PLS-00068 (excluded) | PMID 38314601Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer. | primary |
| PLS-00069 (excluded) | PMID 37834399MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake-A Preliminary Study. | primary |
| PLS-00070 (excluded) | PMID 37750635The relationship of circulating MOTS-c level with liver fibrosis and metabolic components in patients with metabolic dysfunction-associated fatty liver disease. | primary |
| PLS-00071 (excluded) | PMID 33468709A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. | primary |
| PLS-00072 (excluded) | PMID 36629605Evaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCI. | primary |
| PLS-00073 (excluded) | PMID 37077579Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function. | primary |
| PLS-00074 (excluded) | PMID 42349896Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy. | primary |
| PLS-00075 (excluded) | PMID 32182209Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. | primary |
| PLS-00076 (excluded) | PMID 36844198Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study. | primary |
| PLS-00077 (excluded) | PMID 36799414Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects. | primary |
| PLS-00078 (excluded) | PMID 35989823Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls. | primary |
| PLS-00079 (excluded) | PMID 39469962Serum MOTS-c levels remain unchanged in patients with preeclampsia. | primary |
| PLS-00080 (excluded) | PMID 36066139MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease. | primary |
| PLS-00081 (excluded) | PMID 29242099Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. | primary |
| PLS-00082 (excluded) | PMID 29593067Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals. | primary |
| PLS-00083 (excluded) | PMID 36303331Adropin and MOTS-c as new peptides: Do levels change in neurodegenerative diseases and ischemic stroke? | primary |
| PLS-00084 (excluded) | PMID 31066084Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects. | primary |
| PLS-00085 (excluded) | PMID 39077591The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes. | primary |
| PLS-00086 (excluded) | PMID 38112134Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation. | primary |
| PLS-00087 (excluded) | PMID 31432706Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease. | primary |
| PLS-00088 (excluded) | PMID 34681131Changes in MOTS-c Level in the Blood of Pregnant Women with Metabolic Disorders. | primary |
| PLS-00089 (excluded) | PMID 31088495A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome. | primary |
| PLS-00090 (excluded) | PMID 34351816Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. | primary |
| PLS-00091 (excluded) | PMID 35789022Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities. | primary |
| PLS-00092 (excluded) | PMID 37072092Prediction of Post-Acute-Sequelae of COVID-19 by Cargo Protein Biomarkers of Blood Total Extracellular Vesicles in Acute COVID-19. | primary |
| PLS-00093 (excluded) | PMID 29691953Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance. | primary |
| PLS-00094 (excluded) | PMID 39457696The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults. | primary |
| PLS-00095 (excluded) | PMID 31214116Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects. | primary |
| PLS-00096 (excluded) | PMID 35285072SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19. | primary |
| PLS-00207 (excluded) | PMID 42939841Associations of Serum MOTS-c with Exercise Capacity and Antioxidant Markers in Young Males: A Cross-Sectional Study. | primary |
| PLS-00249 | NCT07505745 · no results postedMOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity | registry entry |
Evidence gaps
Research activity gap: No gap identified
Little indexed research of any kind.
Human research gap: No gap identified
Laboratory or animal research exists, but little human research.
Evidence quality gap: Gap identified
Human research exists, but no assessed outcome reaches moderate or high certainty.
Clinical relevance gap: Gap identified
Studies exist but none directly address a claim being evaluated.
Safety evidence gap: Gap identified
Safety is not established with moderate or high certainty for the populations, routes or durations studied.
Timeline
Registrations, publications, posted results and every change to the assessments.
2017-12-06
Published: Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction.
2018-03-27
Published: Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals.
2018-04-25
Published: Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance.
2019-05-14
Published: A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.
2019-05-15
Published: Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.
2019-05-31
Published: Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects.
2019-08-21
Published: Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease.
2020-03-17
Published: Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.
2021-01-04
Published: Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea.
2021-01-19
Published: A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.
2021-08-05
Published: Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.
2021-08-19
Published: Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.
2021-08-20
Published: Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes.
2021-10-12
Published: Changes in MOTS-c Level in the Blood of Pregnant Women with Metabolic Disorders.
2021-10-30
Published: The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.
2022-03-30
Published: SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19.
2022-05-18
Published: The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes.
2022-07-05
Published: Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.
2022-07-18
Published: Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls.
2022-08-01
Published: MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease.
2022-10-27
Published: Adropin and MOTS-c as new peptides: Do levels change in neurodegenerative diseases and ischemic stroke?
2022-12-06
Published: Circulating levels of MOTS-c in patients with breast cancer treated with metformin.
2023-01-01
Published: Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation.
2023-01-01
Published: Serum MOTS-c levels remain unchanged in patients with preeclampsia.
2023-01-01
Published: Evaluation of Serum Humanin and MOTS-c Peptide Levels in Patients with COVID-19 and Healthy Subjects.
2023-01-09
Published: Evaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCI.
2023-02-08
Published: Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.
2023-04-12
Published: Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function.
2023-04-17
Published: Prediction of Post-Acute-Sequelae of COVID-19 by Cargo Protein Biomarkers of Blood Total Extracellular Vesicles in Acute COVID-19.
2023-09-01
Published: The relationship of circulating MOTS-c level with liver fibrosis and metabolic components in patients with metabolic dysfunction-associated fatty liver disease.
2023-10-06
Published: MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake-A Preliminary Study.
2024-01-01
Published: Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer.
2024-04-25
Published: Mitochondrial dysfunction is associated with cognitive impairment in adults with OSA without dementia.
2024-08-07
Published: The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients: A Multicenter Cohort Study.
2024-08-09
Published: Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study.
2024-08-23
Published: Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure.
2024-10-18
Published: The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults.
2024-12-20
Published: Evaluation of vascular peroxidase 1, humanin, MOTS-c and miR-200c expression levels in untreated preeclampsia patients.
2024-12-23
Published: Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?
2025-01-01
Published: MOTS-c as a Potential Diagnostic-prognostic Biomarker for Myocardial Infarction.
2025-02-12
Published: MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study.
2025-02-25
Published: Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea.
2025-02-26
Published: Effects of Glucagon-Like Peptide-1 Receptor Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their Combination on Neurohumoral and Mitochondrial Activation in Patients With Diabetes.
2025-03-13
Published: Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement.
2025-05-15
Published: Circulating mitochondrial biomarkers in acute coronary syndrome.
2025-07-17
Published: Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization.
2025-08-06
Published: Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.
2025-09-26
Published: MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction.
2025-11-09
Published: Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.
2025-11-30
Published: Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis.
2025-12-10
Published: Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.
2025-12-30
Published: Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss.
2026-02-12
Published: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction.
2026-04-01
Registered: NCT07505745
2026-04-07
Published: Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?
2026-04-17
Published: The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study.
2026-05-13
Published: MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study.
2026-05-21
Published: Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients.
2026-05-22
Published: Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study.
2026-06-25
Published: Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.
2026-07-30
Published: AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
2026-10-01
Published: Associations of Serum MOTS-c with Exercise Capacity and Antioxidant Markers in Young Males: A Cross-Sectional Study.
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-07
Study record published (version 1)
2026-11-08
Claim assessment published (version 1)
2026-11-08
Claim assessment published (version 1)
2026-11-08
Certainty assessment published (version 1)
2026-11-08
Certainty assessment published (version 1)
2026-11-08
Study record published (version 1)
2026-11-08
Study record published (version 1)
Sources and method
Every assessment links its sources and keeps its full version history. Methodology · All assessments (CSV) · All study records (CSV)
These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).