Peptide Library

Human study PLS-00090

Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.

Randomized controlled trial · Not reported participants enrolled · not included in the assessments (wrong compound)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans.primary · Journal of applied physiology (Bethesda, Md. : 1985) · 2021-08-05 · PMID 34351816 · DOI

Design and participants

Design
Randomized controlled trial
Population
Human subjects randomized after familiarization to acute endurance exercise, resistance exercise or control. Health status, age range and sex are not described in the abstract.
Setting
Exercise physiology laboratory study with skeletal muscle biopsies and blood sampling (setting not further described).
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
30
Completed follow-up
Not reported
Funding
Indexed as Research Support, Non-U.S. Gov't; funders not named in the record.

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not reported in the abstract; no MOTS-c was administered.

    The authors concluded (paraphrased): Plasma mitochondrial-derived peptide levels are unrelated to fitness status. Acute endurance exercise, but not resistance exercise, raises circulating MDPs, particularly humanin; MOTS-c showed only a trend to increase.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: MOTS-c was not administered; it was measured as an endogenous peptide responding to exercise, so the study gives no evidence on MOTS-c as an intervention.
    • inappropriate endpoint: All outcomes are circulating or tissue biomarkers measured over hours; there are no clinical or metabolic health endpoints.
    • small or imprecise: Only 10 participants per arm, and the MOTS-c change after endurance exercise was described only as a trend.
    • short follow up: Sampling extended only to 3 hours after a single exercise bout.
    • abstract only: Only the abstract is available in the record; randomization methods, attrition and numeric results are not reported.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 34351816, abstract (sentence 4) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 34351816, abstract (sentence 12) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 34351816, abstract (sentence 4) · extracted by AI (automated, not verified by a person) · abstract only
    • funding: PMID 34351816, title (publication types) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 34351816, abstract (sentences 5-6) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 34351816, abstract (sentence 4) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 34351816, abstract (sentences 7-11) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).