what belongs on a research supplies list, boring edition
not the exciting part of this hobby but the part that determines whether anything else works. things that come up repeatedly in what ive read: alcohol swabs, appropriate syringes,…
Peptide Research Community
Discussion of published peptide research — what studies found, how good the evidence is, and what is still unknown.
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Categories
- General DiscussionOpen discussion about peptide research, and anything that does not fit elsewhere.
- Beginner QuestionsNew to reading peptide research? Ask the questions nobody explains properly.
- Peptide ComparisonsHead-to-head discussion: what actually separates two compounds.
- GLP-1 & MetabolicSemaglutide, tirzepatide, retatrutide and the wider metabolic research space.
- Recovery & RepairBPC-157, TB-500, growth-hormone secretagogues and tissue-repair research.
- Longevity & MitochondrialMOTS-c, SS-31, epitalon and the longevity research space.
- Skin, Hair & CosmeticGHK-Cu, AHK-Cu, melanotan and cosmetic-adjacent research.
- Cognitive & NeuroSemax, Selank, dihexa and nootropic peptide research.
- Studies & EvidenceRead a paper? Post it here. Evidence tier gets labelled every time.
- News & New CompoundsNewly published research, regulatory changes and compounds gaining attention.
- Research LogsStructured logs and templates for tracking a research plan over time.
- Tracking & CalculatorDosing arithmetic, reconstitution maths, and how people use the tracker.
- Storage, Reconstitution & SuppliesBacteriostatic water, lyophilised vs reconstituted storage, and research supplies.
- Peptide Library App & Feature RequestsWhat the app should do next. Feature requests and product discussion.
- PollsQuick community polls. The lowest-effort way to join a discussion.
- Community & GuidelinesHow this community works, what is expected, and meta discussion.
Recent discussions
suggestion: evidence tier as a structured field rather than a convention
the studies category convention works but relies on people remembering. a dropdown on the composer would make it consistent and filterable. evidence tier: n/a, this is a process s…
Why is there so little human data on most of these?
Genuine question rather than a rhetorical one. If some of these compounds have been known about for decades, why has nobody run a proper trial?
New here? Say what you're currently reading about
Low-stakes introduction thread. Not a bio, just: what brought you here and what are you currently trying to understand. It makes the place easier to navigate if people know who's …
p-values in underpowered preclinical work
a significant result from n=8 tells you less than most people assume, and a null result from n=8 tells you almost nothing at all. the asymmetry is worth holding onto. evidence tie…
Paper discussion: post one you've read this month and state its tier
Recurring thread. Format: - What compound - What was actually measured - Species and n - Evidence tier - What you took from it The format matters more than the paper. It's the hab…
what the numbers on a vial label mean
the label says a mass, which i now understand is the total amount of powder in there, not a concentration. concentration only exists once you add liquid. is that right? because it…
Expiry date vs beyond-use date — not the same thing
Small distinction that causes real confusion. Expiry date is set by the manufacturer for the unopened product stored as directed. It's backed by stability testing on that product …
registry results reporting compliance is worse than i expected
went looking for completed trials with posted results and the gap between completion and reporting is large across the board. not specific to this space but relevant to how much w…
The five arithmetic mistakes that account for most of the confusion in this category
Collected from the threads in this category over the last few months. 1. Treating syringe units as a mass. They're a volume marking. Meaningless without a concentration. 2. mg/mcg…
how do people handle temperature when travelling
the storage threads all assume a fridge you control. what do people do when that isnt available for a few days
Question of the week: what's one thing you changed your mind about?
Starting a recurring weekly question, since the threads that go best here are the ones with a specific prompt. This week: what's something you believed about this space that you n…
"GLP-1" has become a category label for things that aren't GLP-1 agonists
Small terminology gripe that causes real confusion. GLP-1 agonist means an agonist at the GLP-1 receptor. Semaglutide is one. Tirzepatide is a dual GLP-1/GIP agonist. Retatrutide …
Melanotan 1 vs 2 — selectivity is the difference that explains the different side effect profiles
The melanocortin receptor family has several members with quite different roles, which is the whole story here. Melanotan 1 (afamelanotide) is comparatively selective for MC1R, th…
Looking for standard glutathione dosing
Looking for dosing
Glow vs KLOW — blends make attribution basically impossible and I think that's the main point
Glow is generally GHK-Cu / BPC-157 / TB-500. KLOW adds KPV to that. So the difference is one component. But the more interesting thing to me is the structural problem with blends …
Is reconstitution solution the same as bacteriostatic water?
Short answer: sometimes, and you can't tell from the name. "Reconstitution solution" describes a purpose, not a composition. Products sold under that description vary — some are b…
The discontinuation data is the most under-discussed part of this entire class
Everyone quotes the efficacy numbers. Almost nobody quotes what happens after stopping. The published withdrawal and extension data across this class shows substantial regain foll…
AHK-Cu vs GHK-Cu — two copper peptides with very different amounts of research behind them
Both are copper-binding tripeptides. That shared chemistry is why they get shelved together, and it's about where the similarity ends in terms of what's actually been studied. GHK…
A conversion reference that actually covers the cases people get wrong
Written out because the errors cluster in predictable places. Mass 1 mg = 1000 mcg. 1 mcg = 0.001 mg. Volume 1 mL = 1000 µL (mcL). U-100 syringe: 100 units = 1 mL, so 1 unit = 0.0…
Healing for bulging disc
I am researching the use of localised BPC-157 injections into the back of my neck, 2 times a day 500mcg each, and 2.5mg injection of TB-500 2x a week to try and reduce inflammatio…
Does bacteriostatic water itself need refrigerating?
Separating two questions that get merged. The bacteriostatic water on its own: generally stored at controlled room temperature. It doesn't require refrigeration. Manufacturer labe…
Ipamorelin vs Sermorelin — different receptors, and that's the bit people skip
These get treated as two flavours of the same thing. They act on different receptors. Sermorelin is a GHRH analogue — GHRH(1-29). It works on the GHRH receptor, the same pathway a…
How reconstitution actually works, step by step, and the two places people go wrong
The mechanics, described rather than prescribed. The process as generally described in the literature: 1. Let a cold vial come to room temperature first. Adding liquid to cold pow…
Oral vs injectable in this class — why the oral versions are a genuinely hard problem
Peptides are generally destroyed in the gut, which is why almost everything in this space is injectable. Getting an oral version to work is a real pharmaceutical achievement rathe…
Semax vs Selank — these get bundled constantly but they're aimed at different things
Both come out of the same Russian research tradition and get sold side by side, which I think is why people treat them as interchangeable. They aren't really. Semax is an ACTH(4-1…
Bacteriostatic water vs sterile water — when does the difference actually matter?
Both are sterile at the point of opening. The difference is what happens afterwards. Sterile water has no preservative. Once opened it has no ongoing protection. Bacteriostatic wa…
Retatrutide vs semaglutide — comparing across trials is the trap here
There is no direct head-to-head between these. Every comparison you see is cross-trial. Cross-trial comparison is unreliable for reasons that are boring but decisive: different po…
CJC-1295 with DAC vs without — the half-life difference is the whole story, isn't it?
Trying to state this cleanly because the naming is a mess. CJC-1295 with DAC has a drug affinity complex that binds albumin, which extends the half-life dramatically — days rather…
Lyophilised vs reconstituted storage — two completely different problems
Short version of something that keeps getting mixed up. Storage advice for the powder does not transfer to the solution, and vice versa. They're different physical states with dif…
Discussions are educational and cover published research. Nothing here is individualised medical advice.