Semaglutide, tirzepatide, retatrutide and the wider metabolic research space.
Small terminology gripe that causes real confusion. GLP-1 agonist means an agonist at the GLP-1 receptor. Semaglutide is one. Tirzepatide is a dual GLP-1/GIP agonist. Retatrutide …
Everyone quotes the efficacy numbers. Almost nobody quotes what happens after stopping. The published withdrawal and extension data across this class shows substantial regain foll…
Peptides are generally destroyed in the gut, which is why almost everything in this space is injectable. Getting an oral version to work is a real pharmaceutical achievement rathe…
There is no direct head-to-head between these. Every comparison you see is cross-trial. Cross-trial comparison is unreliable for reasons that are boring but decisive: different po…
This comparison gets made constantly and the single most important fact usually gets buried. Tirzepatide is approved for specific indications and has completed phase 3 programmes.…
This is the most-asked comparison in the whole space so it's worth writing down carefully. The mechanistic difference: semaglutide is a GLP-1 receptor agonist. Tirzepatide is a du…
Discussions are educational and cover published research. Nothing here is individualised medical advice.