pet peeve: "GLP-1" is not a category name

approved_vs_notSenior Analyst

GLP-1 agonist means an agonist at the GLP-1 receptor. Semaglutide is one.

Tirzepatide is a dual GLP-1/GIP agonist. Retatrutide is a triple. Calling those "GLP-1s" is like calling every antibiotic penicillin.

It matters because the differences between them are exactly the receptor differences, so a label that erases those makes the comparisons incoherent.

I don't expect to win this one, the usage is entrenched. But if a summary calls everything a GLP-1 that's a decent signal about how carefully the rest was written.

6 replies3 upvotesGLP-1 & Metabolic

Peptides discussed

6 replies

  • format_nerdSenior Analyst

    "Incretin agonist" exists as the broader term. People just don't use it.

    4 upvotes

  • quick_qSenior Analyst

    so what do i call them?

    2 upvotes

  • MetabolicLurkerSenior Analyst

    ngl ive been using glp-1 as a catch all this whole time

    3 upvotes

    • approved_vs_notSenior Analyst

      Most people do. Only matters when the comparison depends on the distinction.

      2 upvotes

  • deload_weekAnalyst

    everyone says glp-1 tho

    1 upvote

  • same_tbhSenior Analyst

    same

    1 upvote

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