Peptide Library

Human study PLS-00071

A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.

Cross-sectional study · 27,527 participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.primary · Aging · 2021-01-19 · PMID 33468709 · DOI

Design and participants

Design
Cross-sectional study
Population
Participants of three cohorts (J-MICC, MEC, TMM) genotyped for the m.1382A>C mtDNA polymorphism, analysed by sex for type 2 diabetes prevalence
Conditions
Type 2 diabetes mellitus
Setting
Population cohorts (J-MICC, MEC, TMM) combined by meta-analysis
Planned enrollment (registry)
Not reported
Enrolled
27,527
Randomized
Not reported
Completed follow-up
Not reported

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety, and how safety was monitored isn’t described.

    The authors concluded (paraphrased): The Asian-specific m.1382A>C polymorphism is associated with type 2 diabetes susceptibility in men, possibly interacting with physical activity. It may raise risk in sedentary males by reducing MOTS-c activity.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • inappropriate population: Humans were genotyped for a MOTS-c gene variant but were never given MOTS-c. Administration occurred only in mice.
    • confounding: The observational genetic association of prevalence may be confounded, and the sex and physical activity subgroup findings are post hoc in nature.
    • abstract only: Only the PubMed abstract is available in the record, so methods and effect estimates are not reported.
    • other: Humans were genotyped and not given MOTS-c. The peptide was given only to mice and tested in vitro, so no human intervention data exist.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • author_conclusion: PMID 33468709, abstract (final sentence) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 33468709, abstract (sentence 4) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 33468709, abstract (sentences 6-8) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 33468709, abstract (sentence 4) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 33468709, abstract (sentences 3-5) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).