Peptide Library

Human study PLS-00073

Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function.

Cross-sectional study · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function.primary · Diabetes, metabolic syndrome and obesity : targets and therapy · 2023-04-12 · PMID 37077579 · DOI

Design and participants

Design
Cross-sectional study
Population
Obese children and healthy control children, of similar mean age in each group.
Conditions
Childhood obesity, Vascular endothelial dysfunction
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not applicable; no compound was administered.

    The authors concluded (paraphrased): The authors concluded that MOTS-C is a previously unknown regulator in the development of obesity-induced vascular changes.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: Endogenous MOTS-C was measured; no MOTS-C was administered, so the study cannot inform effects of the compound.
    • confounding: Cross-sectional group comparison; the abstract does not report adjustment for confounders.
    • abstract only: Only a truncated abstract is available; the result statistics are cut off in the record.
    • inappropriate population: The participants are children, whereas the claim concerns adults with obesity or diabetes.
    • no control group: No intervention was given. The study compares endogenous levels between obese and healthy children, so it cannot show effects of administering MOTS-C.
    • inappropriate endpoint: Serum MOTS-C level and reactive hyperemia index are biomarker and surrogate measures, not clinical outcomes of treatment.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 37077579, abstract (Patients and methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 37077579, abstract (Conclusion, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 37077579, abstract (Patients and methods, sentences 1-4) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 37077579, abstract (Patients and methods and Results) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 37077579, abstract (Patients and methods, sentences 3-4) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 37077579, abstract (Patients and methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 37077579, abstract (Patients and methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 37077579, abstract (Results, sentence 1 (truncated)) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).