Peptide Library

Human study PLS-00060

Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.

Randomized controlled trial · 49 participants enrolled · not included in the assessments (wrong compound)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors.primary · Scientific reports · 2021-08-19 · PMID 34413391 · DOI

Design and participants

Design
Randomized controlled trial
Population
Hispanic and non-Hispanic White breast cancer survivors (Stage I-III), in a secondary analysis of an exercise trial
Conditions
Breast cancer survivorship
Setting
Not stated; secondary analysis of a registered randomized exercise trial (NCT01140282)
Planned enrollment (registry)
Not reported
Enrolled
49
Randomized
Not reported
Completed follow-up
Not reported
Funding
Research Support, N.I.H., Extramural (per publication type); details not stated
Authors’ conflicts
Not stated in the record

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not reported in the abstract

    The authors concluded (paraphrased): A 16-week aerobic and resistance exercise program increased endogenous MOTS-c levels in non-Hispanic White breast cancer survivors. Post-exercise MOTS-c was associated with improvements in body composition and metabolic markers.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: MOTS-c was not administered; it was measured as an endogenous biomarker of an exercise intervention.
    • abstract only: Only the abstract is available, and it gives no arm sizes, effect estimates or attrition.
    • inappropriate endpoint: The outcomes are plasma MOTS-c and its correlations with surrogate metabolic biomarkers.
    • small or imprecise: Only 49 survivors were included, split across ethnic subgroups and two arms.
    • selective reporting: This is a secondary analysis with ethnicity-specific findings; whether it was prespecified is not stated.
    • inappropriate population: The cohort is breast cancer survivors, not people with obesity, insulin resistance or type 2 diabetes.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 34413391, abstract (sentences 5-6) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 34413391, abstract (sentence 13) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 34413391, abstract (sentences 4-5) · extracted by AI (automated, not verified by a person) · abstract only
    • funding: PMID 34413391, title (publication types) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 34413391, abstract (sentences 7-9) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 34413391, abstract (sentence 10) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 34413391, abstract (sentence 5) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 34413391, abstract (sentences 12-13) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).