Peptide Library

Human study PLS-00076

Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.

Cross-sectional study · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.primary · Frontiers in medicine · 2023-02-08 · PMID 36844198 · DOI

Design and participants

Design
Cross-sectional study
Population
Patients with stable COPD and smokers with normal lung function
Conditions
Chronic obstructive pulmonary disease
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety, and how safety was monitored isn’t described.

    The authors concluded (paraphrased): COPD patients had reduced circulating MOTS-c and increased Romo1. Low MOTS-c was associated with oxygen desaturation and poorer six-minute walk performance. Romo1 was associated with current smoking and baseline oxygen saturation.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: No MOTS-c was administered; the study measured only endogenous serum peptide levels, so it cannot inform effects of giving the compound.
    • confounding: Cross-sectional associations between peptide levels and clinical features cannot establish causation.
    • abstract only: Only the abstract is available in the record, so methods and full results cannot be checked.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 36844198, abstract (Methods, sentences 1-2) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 36844198, abstract (Conclusions, sentences 1-3) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 36844198, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 36844198, abstract (Methods, sentences 1-2) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 36844198, abstract (Methods, sentence 2) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 36844198, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 36844198, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 36844198, abstract (Results, sentences 1 and 3) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).