Peptide Library

Human study PLS-00085

The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes.

Cross-sectional study · 105 participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes.primary · Reviews in cardiovascular medicine · 2022-05-18 · PMID 39077591 · DOI

Design and participants

Design
Cross-sectional study
Population
Professional athletes (low/moderate endurance and high endurance) and non-athlete sedentary controls across gender/age groups
Conditions
Chronic endurance exercise (professional athletes)
Planned enrollment (registry)
Not reported
Enrolled
105
Randomized
Not reported
Completed follow-up
Not reported
Funding
not stated
Authors’ conflicts
not stated

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not applicable; no compound administered and no safety monitoring reported

    The authors concluded (paraphrased): The authors saw these as pilot data suggesting that serum MOTS-c and humanin levels change with chronic exercise, with implications for energy metabolism and performance.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: MOTS-c was only measured as an endogenous serum peptide. No one received it, so the study says nothing about its administration.
    • confounding: Athletes and sedentary controls likely differ in many factors besides exercise. Only age and gender adjustment is described.
    • inappropriate endpoint: Outcomes are serum biomarker levels only, with no clinical or metabolic health outcomes.
    • small or imprecise: The authors call this pilot data, the subgroups are small, and the abstract gives no estimates or p-values.
    • abstract only: Only the abstract is available, so methods, confounder handling and numeric results cannot be checked.
    • inappropriate population: Participants were athletes and sedentary controls, not people with metabolic disease, and received no MOTS-c.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 39077591, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 39077591, abstract (Conclusions, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 39077591, abstract (Methods, sentences 1-2) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 39077591, abstract (Methods and Conclusions (pilot data)) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 39077591, abstract (Methods, sentences 2-3) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 39077591, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 39077591, abstract (Background, sentence 3; Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 39077591, abstract (Results, sentences 1-3) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).