Peptide Library

Human study PLS-00065

The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.

Cross-sectional study · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.primary · Biochimica et biophysica acta. General subjects · 2021-10-30 · PMID 34728329 · DOI

Design and participants

Design
Cross-sectional study
Population
Japanese healthy individuals assessed for muscle fiber composition, physically active young Japanese men assessed for muscular strength, and Japanese athletes compared with ethnicity-matched controls for allele frequency.
Conditions
Skeletal muscle fiber composition, Muscular performance
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported
Funding
Research Support, N.I.H., Extramural (per PubMed publication type).

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety, and how safety was monitored isn’t described.

    The authors concluded (paraphrased): The authors suggest that the C allele of the East Asian-specific m.1382A>C polymorphism, which produces MOTS-c K14Q, contributes to sprint/power performance by regulating skeletal muscle fiber composition.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: The exposure is a genotype. MOTS-c was not administered to humans, so the study gives no evidence on effects of giving the compound.
    • abstract only: Only the abstract is available in the record. Methods and full results cannot be appraised.
    • confounding: This is an observational genetic association. The abstract describes no adjustment for population structure or other confounders.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • author_conclusion: PMID 34728329, abstract (last sentence) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 34728329, abstract (sentences 4-8) · extracted by AI (automated, not verified by a person) · abstract only
    • funding: PMID 34728329, title (publication types) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 34728329, abstract (sentences 5-7) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 34728329, abstract (sentences 5-7) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).