Peptide Library

Human study PLS-00086

Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation.

Prospective cohort · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation.primary · Chronic respiratory disease · 2023-01-01 · PMID 38112134 · DOI

Design and participants

Design
Prospective cohort
Population
Adults with COPD: 51 consecutive patients admitted to hospital for COPD exacerbation, and 160 patients with stable COPD from an outpatient clinic as controls
Conditions
Chronic obstructive pulmonary disease, COPD exacerbation
Setting
Single hospital (inpatient admissions and outpatient clinic); patients with exacerbation followed for 1 year
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported
Funding
Research Support, Non-U.S. Gov't (per publication type); details not stated
Authors’ conflicts
Not stated in record

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not applicable; no compound was administered.

    The authors concluded (paraphrased): Most mitochondrial peptides are altered in COPD exacerbation compared with stable COPD. MOTS-c and GDF-15 have diagnostic accuracy similar to CRP, and HN and MOTS-c independently predict re-hospitalization.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • inappropriate population: Endogenous MOTS-c was measured in COPD patients; nobody received MOTS-c, so the study is irrelevant to administration claims.
    • abstract only: Only the abstract is available, and its results section is garbled, with missing values for several peptides.
    • small or imprecise: Only 51 patients with exacerbation; the re-admission hazard ratio has a wide confidence interval (1.252-9.297).
    • confounding: This is an observational biomarker association, and the adjustment set for the Cox model is not described in the abstract.
    • inappropriate endpoint: Endogenous serum MOTS-c was measured as a biomarker. No MOTS-c was administered, so the study cannot inform effects or safety of the compound.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 38112134, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 38112134, abstract (Conclusions) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 38112134, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • funding: PMID 38112134, abstract (publication types) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 38112134, abstract (Background, final sentence; Results) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 38112134, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 38112134, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 38112134, abstract (Results, final sentence) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).