Peptide Library

Human study PLS-00075

Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.

Cross-sectional study · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.primary · Aging · 2020-03-17 · PMID 32182209 · DOI

Design and participants

Design
Cross-sectional study
Population
Healthy young (18-30 y), middle-aged (45-55 y) and older (70-81 y) men
Conditions
Healthy aging
Setting
not_stated
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported
Funding
Research support from NIH (extramural) and non-US government sources, per PubMed publication types; details not stated
Authors’ conflicts
not_stated

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: not_stated

    The authors concluded (paraphrased): Plasma and muscle MOTS-c appear to be regulated differently with aging. Higher muscle MOTS-c with age fits a fast-to-slow fiber-type transition. Further work is needed to identify its targets in human muscle.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: Only endogenous MOTS-c levels were measured. No exogenous MOTS-c was given, so the study cannot inform effects of administration.
    • abstract only: Only the abstract is available in the record, and sample sizes and methods details are not stated.
    • confounding: Cross-sectional age-group comparisons and correlations are open to confounding and cannot establish causality.
    • no control group: Endogenous levels were compared across age groups. No MOTS-c was administered and there was no intervention or comparator.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • author_conclusion: PMID 32182209, abstract (sentences 6-7) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 32182209, abstract (sentences 2-3) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 32182209, abstract (sentence 2) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 32182209, abstract (sentence 3) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).