Palmitoyl Tripeptide-5
Also known as: Pal-KVK, Syn-Coll
Palmitoyl Tripeptide-5 (also called Pal-KVK or Syn-Coll) is a cosmetic TGF-β mimetic tripeptide in the Matrix / Angiogenic class. Palmitoyl tripeptide-5 is a lipidated tripeptide used topically for effects on dermal collagen.
For research use only.
Key Facts
- CAS
- 623172-55-4
- Molecular Weight (MW)
- —
- Half-life
- Topical; systemic PK not established
- FDA status
- Not Approved
- Administration Route
- Topical
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
- Targets
- TGF-β pathway (claimed)Collagen I
Vendor price snapshot
Each vendor's price is the median price per mg of its own listings; with fewer than 3 vendors there is no typical range. From public vendor listings collected in Dec 2025, so confirm the live price on the vendor site. Peptide Library does not sell peptides.
- Vendors listing this peptide
- 1
- Listed offers
- 1
- Price per mg
- $1.05/mg
Research summary
Lipidated tripeptide marketed under the Syn-Coll name and used topically in firming and anti-ageing formulations. It is described as a thrombospondin-1 mimetic, intended to promote activation of transforming growth factor beta already present in the dermis rather than to supply new growth factor. Evidence comes predominantly from supplier research and small cosmetic studies. A cosmetic active, not a drug, and not FDA-approved.
Peptide Library's Palmitoyl Tripeptide-5 profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- Per cosmetic formulation
- Frequency
- —
- Cycle
- —
- Administration Route
- Topical
- Reconstitution Guide
- —
Not yet checked against primary sources
These figures are compiled from earlier reference material. They have not been verified against FDA labelling, registered trials or published literature, no citation is attached to them, and none of them is a recommended dose. Palmitoyl Tripeptide-5 is queued for dosage evidence review.
Compare reported doses across the whole librarySequence & molecular data
| Molecular formula | C33H65N5O5 |
|---|---|
| Molecular weight | — |
| CAS number | 623172-55-4 |
| Half-life | Topical; systemic PK not established |
| Appearance | White powder |
| Formulation | Topical Cream |
| PubChem CID | 11950477 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
Palmitoyl tripeptide-5 is a lipidated tripeptide used topically for effects on dermal collagen. It is described as a mimetic of thrombospondin-1, the endogenous activator of latent transforming growth factor beta, and the proposed mechanism is that it promotes conversion of latent TGF-beta already present in the dermis into its active form rather than supplying new growth factor. Active TGF-beta drives fibroblast collagen synthesis. The evidence is predominantly supplier research and small cosmetic studies; independent controlled trials of the isolated peptide have not been published, and topical penetration remains the general constraint for peptides of this size.
Origin
Synthetic palmitoylated tripeptide.
Targets
Studies
- Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study
- Usage of Synthetic Peptides in Cosmetics for Sensitive Skin
- Lipidated peptide nanostructures for stabilizing hydrogels with sustained skincare bioactivity
- Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects
- Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels
Regulatory & research status
Palmitoyl Tripeptide-5 is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Availability | OTC / Supplement |
| WADA (sport) | Permitted |
| Library classification | Research-Only |
Benefits
Palmitoyl Tripeptide-5 side effects
Side Effects
- Irritation
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Cosmetic peptides in this library are formulated into topical products; follow the product label rather than the reconstitution guidance above.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Palmitoyl Tripeptide-5: frequently asked questions
What is Palmitoyl Tripeptide-5?
Lipidated tripeptide marketed under the Syn-Coll name and used topically in firming and anti-ageing formulations. It is described as a thrombospondin-1 mimetic, intended to promote activation of transforming growth factor beta already present in the dermis rather than to supply new growth factor. Evidence comes predominantly from supplier research and small cosmetic studies. A cosmetic active, not a drug, and not FDA-approved.
How does Palmitoyl Tripeptide-5 work?
Palmitoyl tripeptide-5 is a lipidated tripeptide used topically for effects on dermal collagen. It is described as a mimetic of thrombospondin-1, the endogenous activator of latent transforming growth factor beta, and the proposed mechanism is that it promotes conversion of latent TGF-beta already present in the dermis into its active form rather than supplying new growth factor.
Is Palmitoyl Tripeptide-5 FDA approved?
No. Palmitoyl Tripeptide-5 is not approved by the FDA for any indication and is categorised as otc / supplement. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What is the half-life of Palmitoyl Tripeptide-5?
Reported half-life for Palmitoyl Tripeptide-5 is Topical; systemic PK not established. Half-life describes how long the compound persists in circulation, not how long any effect lasts, and published figures vary with route of administration, formulation and the population studied.
Is Palmitoyl Tripeptide-5 banned in sport?
Palmitoyl Tripeptide-5 is recorded here as permitted in sport. Anti-doping status is revised annually, so athletes subject to testing should confirm against the current WADA Prohibited List before use.
What peptides are similar to Palmitoyl Tripeptide-5?
Compounds most often compared with Palmitoyl Tripeptide-5 include Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8 and Acetyl Octapeptide-3. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- PubChem Pal-KVKExternal reference
- Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study — J Cosmet Dermatol, 2020External reference
- Usage of Synthetic Peptides in Cosmetics for Sensitive Skin — Pharmaceuticals (Basel), 2021External reference
- Lipidated peptide nanostructures for stabilizing hydrogels with sustained skincare bioactivity — J Control Release, 2026External reference
- Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects — Colloids Surf B Biointerfaces, 2025External reference
- Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels — Molecules, 2023External reference
Related research, comparisons & guides
Related peptides
Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This Palmitoyl Tripeptide-5 profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
Track Palmitoyl Tripeptide-5 research, inventory and reconstitution in the free Peptide Library app. Get the app for iOS or Android →