Acetyl Tetrapeptide-3
Acetyl Tetrapeptide-3 is a cosmetic hair and skin matrikine. Acetyl tetrapeptide-3 is described as a matrikine — a peptide fragment that signals extracellular matrix remodelling. Supplier research reports increased expression of extracellular matrix proteins around the hair follicle, including collagen and laminin, with the stated aim of improving follicle anchoring.
For research use only.
Key Facts
- CAS
- 827306-88-7
- Molecular Weight (MW)
- 509.6 g/mol
- Half-life
- —
- FDA status
- Not Approved
- Administration Route
- topical
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Research summary
Short acetylated tetrapeptide used topically in hair-density and skin-firmness formulations, commonly paired with red clover extract in commercial blends. Regulated as a cosmetic ingredient, not FDA-approved as a drug.
Peptide Library's Acetyl Tetrapeptide-3 profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- —
- Frequency
- —
- Cycle
- —
- Administration Route
- topical
- Reconstitution Guide
- —
Sequence & molecular data
| Molecular formula | C22H39N9O5 |
|---|---|
| Molecular weight | 509.6 g/mol |
| CAS number | 827306-88-7 |
| PubChem CID | 11752568 |
| FDA UNII | D1HW9N9QBX |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
Acetyl tetrapeptide-3 is described as a matrikine — a peptide fragment that signals extracellular matrix remodelling. Supplier research reports increased expression of extracellular matrix proteins around the hair follicle, including collagen and laminin, with the stated aim of improving follicle anchoring. Independent published data on the isolated peptide is limited.
Studies
- An Herbal Extract Combination (Biochanin A, Acetyl tetrapeptide-3, and Ginseng Extracts) versus 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A 24-week, Prospective, Randomized, Triple-blind, Controlled Trial
- Chemical agents and peptides affect hair growth (class-level evidence)
- Topical Carrier-Free Delivery of Finasteride and Peptides for Enhanced Hair Growth (class-level evidence)
- Emerging pharmacotherapies and regenerative solutions for promoting hair growth for androgenetic alopecia (class-level evidence)
- Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion (class-level evidence)
Regulatory & research status
Acetyl Tetrapeptide-3 is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Research status | Research-only compound; no approval pathway listed |
| Availability | OTC / Supplement |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
—
Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Cosmetic peptides in this library are formulated into topical products; follow the product label rather than the reconstitution guidance above.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Acetyl Tetrapeptide-3: frequently asked questions
What is Acetyl Tetrapeptide-3?
Short acetylated tetrapeptide used topically in hair-density and skin-firmness formulations, commonly paired with red clover extract in commercial blends. Regulated as a cosmetic ingredient, not FDA-approved as a drug.
How does Acetyl Tetrapeptide-3 work?
Acetyl tetrapeptide-3 is described as a matrikine — a peptide fragment that signals extracellular matrix remodelling. Supplier research reports increased expression of extracellular matrix proteins around the hair follicle, including collagen and laminin, with the stated aim of improving follicle anchoring.
Is Acetyl Tetrapeptide-3 FDA approved?
No. Acetyl Tetrapeptide-3 is not approved by the FDA for any indication and is categorised as otc / supplement. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to Acetyl Tetrapeptide-3?
Compounds most often compared with Acetyl Tetrapeptide-3 include Biotinoyl Tripeptide-1, Decapeptide-12, Myristoyl Pentapeptide-17 and Palmitoyl Hexapeptide-12. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- An Herbal Extract Combination (Biochanin A, Acetyl tetrapeptide-3, and Ginseng Extracts) versus 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A 24-week, Prospective, Randomized, Triple-blind, Controlled Trial — J Clin Aesthet Dermatol, 2020External reference
- Class-level evidence — Chemical agents and peptides affect hair growth — J Invest Dermatol, 1993External reference
- Class-level evidence — Topical Carrier-Free Delivery of Finasteride and Peptides for Enhanced Hair Growth — Biomacromolecules, 2026External reference
- Class-level evidence — Emerging pharmacotherapies and regenerative solutions for promoting hair growth for androgenetic alopecia — Front Pharmacol, 2026External reference
- Class-level evidence — Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion — Mol Ther Nucleic Acids, 2025External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This Acetyl Tetrapeptide-3 profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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