Biotinoyl Tripeptide-1
Biotinoyl Tripeptide-1 is a cosmetic hair peptide. The peptide couples biotin to the GHK tripeptide, which has affinity for copper and is reported to interact with extracellular matrix components around the hair follicle. Cosmetic literature describes improved anchoring of the hair shaft through effects on follicle basement membrane proteins such as laminin and collagen IV.
For research use only.
Key Facts
- CAS
- 299157-54-3
- Molecular Weight (MW)
- 566.7 g/mol
- Half-life
- —
- FDA status
- Not Approved
- Administration Route
- topical
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Research summary
Biotin-conjugated tripeptide used in topical hair and lash products, typically as part of proprietary blends. Not FDA-approved as a drug; regulated as a cosmetic ingredient.
Peptide Library's Biotinoyl Tripeptide-1 profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- —
- Frequency
- —
- Cycle
- —
- Administration Route
- topical
- Reconstitution Guide
- —
Sequence & molecular data
| Molecular formula | C24H38N8O6S |
|---|---|
| Molecular weight | 566.7 g/mol |
| CAS number | 299157-54-3 |
| PubChem CID | 11534242 |
| FDA UNII | O6380721VA |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
The peptide couples biotin to the GHK tripeptide, which has affinity for copper and is reported to interact with extracellular matrix components around the hair follicle. Cosmetic literature describes improved anchoring of the hair shaft through effects on follicle basement membrane proteins such as laminin and collagen IV. Evidence comes predominantly from manufacturer studies of finished formulations rather than independent trials of the isolated peptide.
Studies
- Topical peptides as cosmeceuticals (class-level)
- Skin ageing and topical rejuvenation strategies (class-level)
- A novel cell-penetrating peptide supports hair follicle growth through anti-inflammatory and growth factor-associated mechanisms in preclinical models (class-level evidence)
- An androgenetic alopecia remedy based on marine collagen peptide-incorporated dissolving microneedles (class-level evidence)
- Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing (class-level evidence)
Regulatory & research status
Biotinoyl Tripeptide-1 is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Research status | Research-only compound; no approval pathway listed |
| Availability | OTC / Supplement |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
—
Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Cosmetic peptides in this library are formulated into topical products; follow the product label rather than the reconstitution guidance above.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Biotinoyl Tripeptide-1: frequently asked questions
What is Biotinoyl Tripeptide-1?
Biotin-conjugated tripeptide used in topical hair and lash products, typically as part of proprietary blends. Not FDA-approved as a drug; regulated as a cosmetic ingredient.
How does Biotinoyl Tripeptide-1 work?
The peptide couples biotin to the GHK tripeptide, which has affinity for copper and is reported to interact with extracellular matrix components around the hair follicle. Cosmetic literature describes improved anchoring of the hair shaft through effects on follicle basement membrane proteins such as laminin and collagen IV.
Is Biotinoyl Tripeptide-1 FDA approved?
No. Biotinoyl Tripeptide-1 is not approved by the FDA for any indication and is categorised as otc / supplement. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to Biotinoyl Tripeptide-1?
Compounds most often compared with Biotinoyl Tripeptide-1 include Acetyl Tetrapeptide-3, Decapeptide-12, Myristoyl Pentapeptide-17 and Palmitoyl Hexapeptide-12. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Class-level evidence — Topical peptides as cosmeceuticals. Indian J Dermatol Venereol Leprol, 2017External reference
- Class-level evidence — Skin ageing and topical rejuvenation strategies. Br J Dermatol, 2023External reference
- Class-level evidence — A novel cell-penetrating peptide supports hair follicle growth through anti-inflammatory and growth factor-associated mechanisms in preclinical models — BMC Biotechnol, 2026External reference
- Class-level evidence — An androgenetic alopecia remedy based on marine collagen peptide-incorporated dissolving microneedles — Int J Pharm, 2024External reference
- Class-level evidence — Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing — Antioxidants (Basel), 2023External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This Biotinoyl Tripeptide-1 profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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