Acetyl Hexapeptide-8
CosmeticCosmetic SNARE-targeting peptideExperimental
Topical hexapeptide (Argireline) used in cosmetics as a SNAP-25 fragment analog. Marketed to soften expression lines; not an FDA-approved drug.
For research use only.
Key Facts
- CAS
- 616204-22-9
- Molecular Weight (MW)
- —
- Half-life
- Topical; systemic PK not established
- Unit
- mcg
- Administration Route
- Topical
- Frequency
- —
- Last updated
- 8/23/2026
- Targets
- SNAP-25 / SNARE complex
Overview
Topical hexapeptide (Argireline) used in cosmetics as a SNAP-25 fragment analog. Marketed to soften expression lines; not an FDA-approved drug.
Protocol
- Dosage Range
- Per cosmetic formulation
- Frequency
- —
- Cycle
- —
- Administration Route
- Topical
- Reconstitution Guide
- —
Science
Mechanism of Action
Mimics the N-terminal of SNAP-25 and can interfere with SNARE-complex assembly in vitro, reducing catecholamine release in model systems. Clinical cosmetic data are mostly small topical studies.
Targets
SNAP-25 / SNARE complex
Studies
- Acetyl hexapeptide-8 topical wrinkle studies— Journal/year not available
Benefits
Topical expression-line researchCosmetic skin-smoothing claimsNon-injectable cosmetic use
Potential Side Effects
- Mild irritation
- Redness
- Contact dermatitis (uncommon)
References
- PMID 15645907External link · Year —
- PubChem ArgirelineExternal link · Year —