Palmitoyl Pentapeptide-4
CosmeticCosmetic matrikineExperimental
Palmitoylated KTTKS matrikine (Matrixyl) used in anti-wrinkle cosmetics. Not an FDA drug. Not WADA-prohibited as a cosmetic peptide.
For research use only.
Key Facts
- CAS
- 214047-00-4
- Molecular Weight (MW)
- ≈802.07 g/mol
- Half-life
- Topical; systemic PK not established
- Unit
- mcg
- Administration Route
- Topical (cosmetic)
- Frequency
- —
- Last updated
- 8/23/2026
- Targets
- Dermal fibroblastsCollagen synthesis
Overview
Palmitoylated KTTKS matrikine (Matrixyl) used in anti-wrinkle cosmetics. Not an FDA drug. Not WADA-prohibited as a cosmetic peptide.
Protocol
- Dosage Range
- Topical concentrations per cosmetic formulation (not a drug)
- Frequency
- —
- Cycle
- —
- Administration Route
- Topical (cosmetic)
- Reconstitution Guide
- —
Science
Mechanism of Action
Procollagen fragment analog that can upregulate ECM proteins in dermal fibroblasts and modestly reduce wrinkle appearance in topical studies.
Targets
Dermal fibroblastsCollagen synthesis
Studies
- Palmitoyl pentapeptide-4 wrinkle study— Journal/year not available
Benefits
Topical collagen-signal cosmetics
Potential Side Effects
- Mild irritation
References
- PMID 15689218External link · Year —