N-Acetyl Semax Amidate
Also known as: NASA
N-Acetyl Semax Amidate (also called NASA) is a modified Semax analog. This is Semax carrying two standard medicinal-chemistry modifications: acetylation of the N-terminus and amidation of the C-terminus. Both changes block exopeptidase attack at the chain ends, the usual route of degradation for short peptides, and the added lipophilicity is the stated rationale for intranasal use.
For research use only.
Key Facts
- CAS
- 2920938-90-3
- Molecular Weight (MW)
- 855 g/mol
- Half-life
- —
- FDA status
- Not Approved
- Administration Route
- Nasal
- Frequency
- Research-dependent
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
- Targets
- Melanocortin-related CNS pathwaysBDNF (by analogy to Semax)
Research summary
N-acetylated, C-amidated Semax analog sold for nootropic research, intended to resist peptidases versus standard Semax. Not FDA-approved.
Peptide Library's N-Acetyl Semax Amidate profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- Often discussed as nasal research use; no approved label
- Frequency
- Research-dependent
- Cycle
- —
- Administration Route
- Nasal
- Reconstitution Guide
- —
- Timing Notes
- Educational catalog only — not medical advice
Sequence & molecular data
| Molecular formula | C39H54N10O10S |
|---|---|
| Molecular weight | 855 g/mol |
| CAS number | 2920938-90-3 |
| Appearance | White lyophilized powder |
| Formulation | Lyophilized Powder |
| PubChem CID | 172638603 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
This is Semax carrying two standard medicinal-chemistry modifications: acetylation of the N-terminus and amidation of the C-terminus. Both changes block exopeptidase attack at the chain ends, the usual route of degradation for short peptides, and the added lipophilicity is the stated rationale for intranasal use. The underlying pharmacology is assumed to match Semax — modulation of brain-derived neurotrophic factor expression and of monoamine transmission, without the corticotropic activity of the ACTH parent. Comparative pharmacokinetic data between the modified and unmodified forms has not been published, so claims of greater potency or duration should be treated as unverified.
Origin
Synthetic modified Semax.
Targets
Studies
- Semax neurotrophic review
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions (class-level evidence)
- Functional Connectomic Approach to Studying Selank and Semax Effects (class-level evidence)
- ACTH(4-10) protects the ADR-injured podocytes by stimulating B lymphocytes to secrete interleukin-10 (class-level evidence)
- Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats (class-level evidence)
Regulatory & research status
N-Acetyl Semax Amidate is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
Potential Side Effects
Side Effects
- Nasal irritation if used IN
- Unknown chronic safety
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
N-Acetyl Semax Amidate: frequently asked questions
What is N-Acetyl Semax Amidate?
N-acetylated, C-amidated Semax analog sold for nootropic research, intended to resist peptidases versus standard Semax. Not FDA-approved.
How does N-Acetyl Semax Amidate work?
This is Semax carrying two standard medicinal-chemistry modifications: acetylation of the N-terminus and amidation of the C-terminus. Both changes block exopeptidase attack at the chain ends, the usual route of degradation for short peptides, and the added lipophilicity is the stated rationale for intranasal use.
Is N-Acetyl Semax Amidate FDA approved?
No. N-Acetyl Semax Amidate is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to N-Acetyl Semax Amidate?
Compounds most often compared with N-Acetyl Semax Amidate include Semax, Adamax, Selank and Cerebrolysin. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Semax PMID 16996037External reference
- Class-level evidence — Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions — J Am Acad Orthop Surg Glob Res Rev, 2026External reference
- Class-level evidence — Functional Connectomic Approach to Studying Selank and Semax Effects — Dokl Biol Sci, 2020External reference
- Class-level evidence — ACTH(4-10) protects the ADR-injured podocytes by stimulating B lymphocytes to secrete interleukin-10 — Int Immunopharmacol, 2020External reference
- Class-level evidence — Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats — Neuropeptides, 2021External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This N-Acetyl Semax Amidate profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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