Semax
CognitiveACTH fragment nootropic / researchExperimental
Synthetic ACTH(4–10) analog used in Russia as a nasal nootropic/neuroprotective peptide. Not FDA-approved.
For research use only.
Key Facts
- CAS
- 80714-61-0
- Molecular Weight (MW)
- 813.92 g/mol
- Half-life
- ~20-30 minutes (nasal)
- Unit
- mcg
- Administration Route
- Intranasal or SubQ
- Frequency
- 1-3x daily
- Last updated
- 8/23/2026
- Targets
- Melanocortin-related CNS pathwaysBDNF
Overview
Synthetic ACTH(4–10) analog used in Russia as a nasal nootropic/neuroprotective peptide. Not FDA-approved.
Protocol
- Dosage Range
- 300-900 mcg
- Frequency
- 1-3x daily
- Cycle
- 4-6 weeks on, 2-4 off
- Administration Route
- Intranasal or SubQ
- Reconstitution Guide
- 3 mL BAC for 30 mg vial
Science
Mechanism of Action
Increases BDNF and modulates monoamines in animal and small human studies; used for stroke and cognitive indications in Russian practice.
Targets
Melanocortin-related CNS pathwaysBDNF
Studies
- Semax BDNF and neuroprotection— Journal/year not available
Benefits
Cognitive enhancementNeuroprotectionStress resilience
Potential Side Effects
- Nasal irritation
- Headache
References
- PMID 16996037External link · Year —