MK-677
Fat LossOral ghrelin-mimetic small moleculeExperimental
Oral non-peptide GH secretagogue (ibutamoren) that raises GH and IGF-1. Not FDA-approved. WADA S2 names ibutamoren (MK-677).
For research use only.
Key Facts
- CAS
- 159752-10-0
- Molecular Weight (MW)
- โ
- Half-life
- ~24 hours
- Unit
- mg
- Administration Route
- Oral
- Frequency
- Once daily
- Last updated
- Aug 23, 2026
- Targets
- GHSR
Vendor price snapshot
Price per mg is list price divided by vial size in milligrams when both are known from public vendor listings. Peptide Library does not sell peptides. Confirm live prices on the vendor site.
- Vendors listing this peptide
- 4
- Listed offers
- 4
- Price per mg range
- $3.60โ$12.00/mg
Overview
Oral non-peptide GH secretagogue (ibutamoren) that raises GH and IGF-1. Not FDA-approved. WADA S2 names ibutamoren (MK-677).
Protocol
- Dosage Range
- Research literature often 10โ25 mg orally once daily โ not an approved label
- Frequency
- Once daily
- Cycle
- Research-dependent
- Administration Route
- Oral
- Reconstitution Guide
- Oral โ no reconstitution
- Timing Notes
- Educational catalog only โ not medical advice
Science
Mechanism of Action
GHSR agonist taken orally once daily in studies; increases GH/IGF-1 and appetite, with fasting glucose and edema as common issues.
Origin
Synthetic spiropiperidine small molecule.
Targets
GHSR
Benefits
Oral GH-axis research tool
Potential Side Effects
Side Effects
- Hunger
- Edema
- Insulin resistance
- Lethargy
References
- PMID 9467542External reference
- WADA Prohibited List 2026External reference