MK-677

Fat LossOral ghrelin-mimetic small moleculeExperimental

Oral non-peptide GH secretagogue (ibutamoren) that raises GH and IGF-1. Not FDA-approved. WADA S2 names ibutamoren (MK-677).

Calculate Dose

For research use only.

Key Facts

CAS
159752-10-0
Molecular Weight (MW)
โ€”
Half-life
~24 hours
Unit
mg
Administration Route
Oral
Frequency
Once daily
Last updated
Aug 23, 2026
Targets
GHSR

Vendor price snapshot

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Vendors listing this peptide
4
Listed offers
4
Price per mg range
$3.60โ€“$12.00/mg

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Overview

Oral non-peptide GH secretagogue (ibutamoren) that raises GH and IGF-1. Not FDA-approved. WADA S2 names ibutamoren (MK-677).

Protocol

Dosage Range
Research literature often 10โ€“25 mg orally once daily โ€” not an approved label
Frequency
Once daily
Cycle
Research-dependent
Administration Route
Oral
Reconstitution Guide
Oral โ€” no reconstitution
Timing Notes
Educational catalog only โ€” not medical advice

Science

Mechanism of Action

GHSR agonist taken orally once daily in studies; increases GH/IGF-1 and appetite, with fasting glucose and edema as common issues.

Origin

Synthetic spiropiperidine small molecule.

Targets

GHSR

Benefits

Oral GH-axis research tool

Potential Side Effects

Side Effects

  • Hunger
  • Edema
  • Insulin resistance
  • Lethargy

References

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