GHRP-1
GHRP-1 is a growth hormone-releasing peptide in the Growth Hormone Secretagogue class. GHRP-1 is a synthetic enkephalin-derived peptide that binds the growth hormone secretagogue receptor 1a on pituitary somatotrophs and hypothalamic neurons, the receptor for ghrelin. Activation stimulates pulsatile growth hormone release through a pathway distinct from and synergistic with growth hormone-releasing hormone.
For research use only.
Key Facts
- CAS
- 141925-59-9
- Molecular Weight (MW)
- 955.1 g/mol
- Half-life
- —
- FDA status
- Not Approved
- Administration Route
- subcutaneous
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Research summary
Synthetic hexapeptide growth hormone secretagogue from the same series as GHRP-2 and GHRP-6. Not FDA-approved and less studied than either. Human pharmacokinetic data is limited.
Peptide Library's GHRP-1 profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- —
- Frequency
- —
- Cycle
- —
- Administration Route
- subcutaneous
- Reconstitution Guide
- —
Sequence & molecular data
| Molecular formula | C51H62N12O7 |
|---|---|
| Molecular weight | 955.1 g/mol |
| CAS number | 141925-59-9 |
| PubChem CID | 10350910 |
| FDA UNII | 39EVI31P0W |
| ChEMBL | CHEMBL427926 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
GHRP-1 is a synthetic enkephalin-derived peptide that binds the growth hormone secretagogue receptor 1a on pituitary somatotrophs and hypothalamic neurons, the receptor for ghrelin. Activation stimulates pulsatile growth hormone release through a pathway distinct from and synergistic with growth hormone-releasing hormone. Selectivity for GH over cortisol and prolactin is lower than that of ipamorelin.
Studies
- Postpartum hyperprolactinemia and hyporesponsiveness of growth hormone (GH) to GH-releasing peptide
- Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men
- Growth hormone (GH) responses to GH-releasing peptide and to GH-releasing hormone in GH-deficient children
- Effect of growth hormone-releasing peptide 1-6 on GH secretion-stimulated by GHRH and pyridostigmine in lambs
- In vivo effects of the GH-releasing heptapeptide GHRP-1 in lambs
Regulatory & research status
GHRP-1 is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Research status | Research-only compound; no approval pathway listed |
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
—
Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
GHRP-1: frequently asked questions
What is GHRP-1?
Synthetic hexapeptide growth hormone secretagogue from the same series as GHRP-2 and GHRP-6. Not FDA-approved and less studied than either. Human pharmacokinetic data is limited.
How does GHRP-1 work?
GHRP-1 is a synthetic enkephalin-derived peptide that binds the growth hormone secretagogue receptor 1a on pituitary somatotrophs and hypothalamic neurons, the receptor for ghrelin. Activation stimulates pulsatile growth hormone release through a pathway distinct from and synergistic with growth hormone-releasing hormone.
Is GHRP-1 FDA approved?
No. GHRP-1 is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to GHRP-1?
Compounds most often compared with GHRP-1 include Ipamorelin, GHRP-6, Pralmorelin (GHRP-2) and Hexarelin (Examorelin). They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Postpartum hyperprolactinemia and hyporesponsiveness of growth hormone (GH) to GH-releasing peptide — J Clin Endocrinol Metab, 1998External reference
- Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men — J Clin Endocrinol Metab, 1992External reference
- Growth hormone (GH) responses to GH-releasing peptide and to GH-releasing hormone in GH-deficient children — J Clin Endocrinol Metab, 1995External reference
- Effect of growth hormone-releasing peptide 1-6 on GH secretion-stimulated by GHRH and pyridostigmine in lambs — J Physiol Biochem, 1998External reference
- In vivo effects of the GH-releasing heptapeptide GHRP-1 in lambs — Reprod Nutr Dev, 1998External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 2
This GHRP-1 profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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