GHK-Cu (Copper Peptide)

Muscle/RecoveryCopper tripeptide / cosmetic and researchExperimental

Endogenous glycyl-L-histidyl-L-lysine copper complex used widely in cosmetics for skin remodeling. Injectable research use is unapproved. USADA lists GHK (tripeptide-1) as not prohibited.

Calculate Dose

For research use only.

Key Facts

CAS: 89030-95-5
Molecular Weight (MW): 403.92 g/mol
Half-life: Short; typically used topically
Unit: mg
Administration Route: Subcutaneous (systemic) or topical (cosmetic)
Frequency: 2–7× weekly depending on route
Last updated: 8/23/2026
Targets: Copper-dependent enzymesExtracellular matrix

Overview

Endogenous glycyl-L-histidyl-L-lysine copper complex used widely in cosmetics for skin remodeling. Injectable research use is unapproved. USADA lists GHK (tripeptide-1) as not prohibited.

Protocol

Dosage Range: 1–2 mg per dose (injectable) or topical per product guidance
Frequency: 2–7× weekly depending on route
Cycle: Ongoing or 4–12 week blocks
Administration Route: Subcutaneous (systemic) or topical (cosmetic)
Reconstitution Guide: Injectable: add 1–2 mL bacteriostatic water per vial as desired.

Science

Mechanism of Action

GHK binds Cu2+ and can modulate metalloproteinases, collagen/elastin synthesis, and anti-inflammatory gene expression in skin explant and cell studies.