Mazdutide
Also known as: IBI362, LY3305677, Xinermei (China)
Mazdutide (also called IBI362 or LY3305677) is a glucagon dual agonist (NMPA-approved; not FDA) in the GLP-1 Agonist class. Mazdutide is a dual agonist at the GLP-1 and glucagon receptors derived from the oxyntomodulin scaffold and acylated for weekly administration.
For research use only.
Key Facts
- CAS
- 2259884-03-0
- Molecular Weight (MW)
- 4476 g/mol
- Half-life
- —
- FDA status
- Not Approved
- Administration Route
- Subcutaneous
- Frequency
- Once weekly
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
- Targets
- GLP-1 receptorGlucagon receptor
Vendor price snapshot
Price per mg is list price divided by vial size in milligrams when both are known from public vendor listings. Peptide Library does not sell peptides. Confirm live prices on the vendor site.
- Vendors listing this peptide
- 2
- Listed offers
- 2
- Price per mg range
- $16.67/mg
Research summary
Dual agonist at the GLP-1 and glucagon receptors, developed principally in China and approved there by the National Medical Products Administration in 2025 for weight management and type 2 diabetes. It combines incretin-driven appetite reduction with glucagon-driven increases in hepatic energy expenditure. It has not been reviewed or approved by the FDA and is not available as a prescription medicine in the United States.
Peptide Library's Mazdutide profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- China label uses 4–6 mg weekly class doses for weight management
- Frequency
- Once weekly
- Cycle
- —
- Administration Route
- Subcutaneous
- Reconstitution Guide
- —
- Injection Sites
- AbdomenThigh
- Timing Notes
- Educational catalog only — not medical advice
Not yet checked against primary sources
These figures are compiled from earlier reference material. They have not been verified against FDA labelling, registered trials or published literature, no citation is attached to them, and none of them is a recommended dose. Mazdutide is queued for dosage evidence review.
Compare reported doses across the whole librarySequence & molecular data
| Molecular formula | C207H317N45O65 |
|---|---|
| Molecular weight | 4476 g/mol |
| CAS number | 2259884-03-0 |
| Appearance | White lyophilized powder |
| Formulation | Lyophilized Powder |
| PubChem CID | 167312357 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
Mazdutide is a dual agonist at the GLP-1 and glucagon receptors derived from the oxyntomodulin scaffold and acylated for weekly administration. GLP-1 receptor activation reduces energy intake and enhances glucose-dependent insulin secretion; glucagon receptor activation increases resting energy expenditure and hepatic fat oxidation. It has been developed principally in China, where phase 3 programmes supported regulatory approval by the National Medical Products Administration. It has not been approved by the FDA, and the balance between the two receptor activities is what determines its glycaemic profile relative to pure GLP-1 agonists.
Origin
Synthetic oxyntomodulin analog (Innovent/Lilly lineage).
Targets
Studies
- Efficacy and Safety of Mazdutide in Managing Overweight and Obesity Among Non-Diabetic Adults: A Meta-Analysis of Randomised Controlled Trials
- Mazdutide Versus Dulaglutide for Weight Loss and Diabetes Management: Meta-Analysis of Randomized Clinical Trials
- Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes
- Mazdutide versus placebo in Chinese adults with type 2 diabetes
- Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight
Regulatory & research status
Mazdutide is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Clinical Trial |
Benefits
Potential Side Effects
Side Effects
- GI AEs
- Increased heart rate possible
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Mazdutide: frequently asked questions
What is Mazdutide?
Dual agonist at the GLP-1 and glucagon receptors, developed principally in China and approved there by the National Medical Products Administration in 2025 for weight management and type 2 diabetes. It combines incretin-driven appetite reduction with glucagon-driven increases in hepatic energy expenditure. It has not been reviewed or approved by the FDA and is not available as a prescription medicine in the United States.
How does Mazdutide work?
Mazdutide is a dual agonist at the GLP-1 and glucagon receptors derived from the oxyntomodulin scaffold and acylated for weekly administration. GLP-1 receptor activation reduces energy intake and enhances glucose-dependent insulin secretion; glucagon receptor activation increases resting energy expenditure and hepatic fat oxidation.
Is Mazdutide FDA approved?
No. Mazdutide is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to Mazdutide?
Compounds most often compared with Mazdutide include Retatrutide, Survodutide, Pemvidutide and Cotadutide. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Efficacy and Safety of Mazdutide in Managing Overweight and Obesity Among Non-Diabetic Adults: A Meta-Analysis of Randomised Controlled Trials — Diabetes Obes Metab, 2026External reference
- Mazdutide Versus Dulaglutide for Weight Loss and Diabetes Management: Meta-Analysis of Randomized Clinical Trials — Am J Ther, 2024External reference
- Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes — Nature, 2026External reference
- Mazdutide versus placebo in Chinese adults with type 2 diabetes — Nature, 2026External reference
- Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight — N Engl J Med, 2025External reference
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This Mazdutide profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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