Wolverine Stack
Also known as: BPC-157 + TB-500, Wolverine blend
Wolverine Stack (also called BPC-157 + TB-500 or Wolverine blend) is a regenerative blend in the Wound Healing / Cytoprotective class. The Wolverine stack is a compounded combination of BPC-157 and TB-500 rather than a single compound, so it has no mechanism of its own beyond those of its parts.
For research use only.
Key Facts
- CAS
- โ
- Molecular Weight (MW)
- โ
- Half-life
- โ
- FDA status
- Not Approved
- Administration Route
- Subcutaneous
- Frequency
- Vendor-dependent
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
- Targets
- Angiogenic / actin pathways (component-dependent)
Vendor price snapshot
Price per mg is list price divided by vial size in milligrams when both are known from public vendor listings. Peptide Library does not sell peptides. Confirm live prices on the vendor site.
- Vendors listing this peptide
- 13
- Listed offers
- 16
- Price per mg range
- $5.00โ$16.99/mg
Research summary
Common shop blend of BPC-157 plus TB-500. Not a single API. Both components are unapproved and WADA-relevant (BPC-157 is S0; TB-500/Tฮฒ4 is prohibited-class).
Peptide Library's Wolverine Stack profile summarises 4 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- See component entries (BPC-157, TB-500) โ blend ratios vary by vendor
- Frequency
- Vendor-dependent
- Cycle
- โ
- Administration Route
- Subcutaneous
- Reconstitution Guide
- โ
- Injection Sites
- AbdomenThigh
- Timing Notes
- Educational catalog only โ not medical advice
Not yet checked against primary sources
These figures are compiled from earlier reference material. They have not been verified against FDA labelling, registered trials or published literature, no citation is attached to them, and none of them is a recommended dose. Wolverine Stack is queued for dosage evidence review.
Compare reported doses across the whole librarySequence & molecular data
| Appearance | White lyophilized powder |
|---|---|
| Formulation | Lyophilized Powder |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
The Wolverine stack is a compounded combination of BPC-157 and TB-500 rather than a single compound, so it has no mechanism of its own beyond those of its parts. BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, reported in animal models to promote angiogenesis through VEGFR2 and focal adhesion kinase signalling and to modulate the nitric oxide system. TB-500 supplies the actin-binding motif of thymosin beta-4, associated with cell migration and angiogenesis in preclinical work. The two are combined on the rationale that they act on complementary aspects of tissue repair, but no controlled trial has evaluated the combination, and the pharmacokinetics of co-administration are uncharacterised.
Origin
Commercial two-peptide blend.
Targets
Studies
- Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review (component evidence (bpc-157))
- Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review (component evidence (bpc-157))
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance (component evidence (tb-500 (thymosin beta-4 fragment)))
- Peptide Supplements and Their Therapeutic Applications in Sports Medicine (component evidence (tb-500 (thymosin beta-4 fragment)))
Regulatory & research status
Wolverine Stack is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Availability | Research-Only |
| WADA (sport) | Banned in Sport |
| Library classification | Research-Only |
Benefits
Potential Side Effects
Side Effects
- Injection reactions
- Component-specific unknowns
Stacking
Common stacking partners
Combinations that include Wolverine Stack, with the proposed rationale, an evidence grade and what is not established, are catalogued in the peptide stacks directory.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freezeโthaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution โ
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544โ575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Wolverine Stack: frequently asked questions
What is Wolverine Stack?
Common shop blend of BPC-157 plus TB-500. Not a single API. Both components are unapproved and WADA-relevant (BPC-157 is S0; TB-500/Tฮฒ4 is prohibited-class).
How does Wolverine Stack work?
The Wolverine stack is a compounded combination of BPC-157 and TB-500 rather than a single compound, so it has no mechanism of its own beyond those of its parts. BPC-157 is a synthetic pentadecapeptide derived from a gastric protein, reported in animal models to promote angiogenesis through VEGFR2 and focal adhesion kinase signalling and to modulate the nitric oxide system.
Is Wolverine Stack FDA approved?
No. Wolverine Stack is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
Is Wolverine Stack banned in sport?
Wolverine Stack is recorded here as prohibited in sport. Athletes subject to anti-doping rules should check the current WADA Prohibited List directly, since it is revised annually and classifications change.
What peptides are similar to Wolverine Stack?
Compounds most often compared with Wolverine Stack include BPC-157, TB-500 (Thymosin Beta-4 fragment), KPV and Pentadeca Arginate. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- WADA Prohibited List 2026External reference
- Component evidence (BPC-157) โ Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent ReviewExternal reference
- Component evidence (BPC-157) โ Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic ReviewExternal reference
- Component evidence (TB-500 (Thymosin Beta-4 fragment)) โ Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic PerformanceExternal reference
- Component evidence (TB-500 (Thymosin Beta-4 fragment)) โ Peptide Supplements and Their Therapeutic Applications in Sports MedicineExternal reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial ยท Reviewed Aug 30, 2026 ยท Updated Aug 30, 2026 ยท Version 1
This Wolverine Stack profile is compiled from published literature (4 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy ยท How profiles are compiled ยท Report an error
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