Noopept
Noopept is a dipeptide nootropic in the Neuromodulator class. Noopept is a proline-containing dipeptide structurally related to the racetam class. It is metabolised in part to cycloprolylglycine, an endogenous dipeptide reported to modulate AMPA and NMDA receptor function.
For research use only.
Key Facts
- CAS
- 157115-85-0
- Molecular Weight (MW)
- 318.4 g/mol
- Half-life
- โ
- FDA status
- Not Approved
- Administration Route
- oral, intranasal
- Frequency
- โ
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Research summary
Synthetic dipeptide developed in Russia and marketed there as a nootropic. It is not FDA-approved and is not a lawful dietary supplement ingredient in the United States. Most published research is Russian-language and preclinical.
Peptide Library's Noopept profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- โ
- Frequency
- โ
- Cycle
- โ
- Administration Route
- oral, intranasal
- Reconstitution Guide
- โ
Sequence & molecular data
| Molecular formula | C17H22N2O4 |
|---|---|
| Molecular weight | 318.4 g/mol |
| CAS number | 157115-85-0 |
| PubChem CID | 180496 |
| FDA UNII | 4QBJ98683M |
| ChEMBL | CHEMBL4303687 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
Noopept is a proline-containing dipeptide structurally related to the racetam class. It is metabolised in part to cycloprolylglycine, an endogenous dipeptide reported to modulate AMPA and NMDA receptor function. Preclinical studies describe increased expression of brain-derived neurotrophic factor and nerve growth factor in the hippocampus, and antioxidant effects; controlled human efficacy data outside Russia is essentially absent.
Studies
- Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) - An active pharmaceutical ingredient with nootropic activity
- Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats
- Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves ฮฑ7AChRs on interneurons in hippocampal slices from rat
- Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats
- Cognitive Enhancer Noopept Activates Transcription Factor HIF-1
Regulatory & research status
Noopept is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Research status | Research-only compound; no approval pathway listed |
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
โ
Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freezeโthaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution โ
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544โ575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Noopept: frequently asked questions
What is Noopept?
Synthetic dipeptide developed in Russia and marketed there as a nootropic. It is not FDA-approved and is not a lawful dietary supplement ingredient in the United States. Most published research is Russian-language and preclinical.
How does Noopept work?
Noopept is a proline-containing dipeptide structurally related to the racetam class. It is metabolised in part to cycloprolylglycine, an endogenous dipeptide reported to modulate AMPA and NMDA receptor function.
Is Noopept FDA approved?
No. Noopept is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What peptides are similar to Noopept?
Compounds most often compared with Noopept include Selank, N-Acetyl Selank Amidate, Semax and Tuftsin. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) - An active pharmaceutical ingredient with nootropic activity โ J Pharm Biomed Anal, 2025External reference
- Effects of noopept on ocular, pancreatic and renal histopathology in streptozotocin induced prepubertal diabetic rats โ Biotech Histochem, 2023External reference
- Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves ฮฑ7AChRs on interneurons in hippocampal slices from rat โ Neurosci Lett, 2022External reference
- Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats โ Int J Mol Sci, 2022External reference
- Cognitive Enhancer Noopept Activates Transcription Factor HIF-1 โ Dokl Biochem Biophys, 2020External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial ยท Reviewed Aug 30, 2026 ยท Updated Aug 30, 2026 ยท Version 2
This Noopept profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy ยท How profiles are compiled ยท Report an error
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