Angiotensin (1-7) Analog
Also known as: AVE0991, Mas-receptor agonist, Angiotensin-(1-7) analog
Angiotensin (1-7) Analog, also called AVE0991 or Mas-receptor agonist, is a mas receptor agonist in the MasR agonist class. Activates the Mas receptor (ACE2/Ang-(1-7)/Mas axis), opposing AT1-driven vasoconstriction and fibrosis in preclinical cardiovascular models. AVE0991 is a non-peptide Mas agonist used as a research tool.
For research use only.
Key Facts
- CAS
- 284038-60-4
- Molecular Weight (MW)
- 902.0 g/mol
- Half-life
- Short; orally active analog tested in rodents
- FDA status
- Not Approved
- Administration Route
- โ
- Frequency
- โ
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
- Targets
- Mas receptor (MAS1)
Research summary
Synthetic Mas-receptor agonist related to angiotensin-(1-7) biology, studied in cardiometabolic and fibrosis models. Not FDA-approved.
Peptide Library's Angiotensin (1-7) Analog profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- Per research protocol
- Frequency
- โ
- Cycle
- โ
- Administration Route
- โ
- Reconstitution Guide
- โ
- Timing Notes
- Explored in hypertension / fibrosis research.
Not yet checked against primary sources
These figures are compiled from earlier reference material. They have not been verified against FDA labelling, registered trials or published literature, no citation is attached to them, and none of them is a recommended dose. Angiotensin (1-7) Analog is queued for dosage evidence review.
Compare reported doses across the whole librarySequence & molecular data
| Molecular formula | C41H62N12O11 |
|---|---|
| Molecular weight | 902.0 g/mol |
| CAS number | 284038-60-4 |
| Half-life | Short; orally active analog tested in rodents |
| Appearance | White powder (research) |
| Formulation | Lyophilized Powder |
| PubChem CID | 9851724 |
| FDA UNII | 68JR6NCI7I |
| ChEMBL | CHEMBL4303593 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
Activates the Mas receptor (ACE2/Ang-(1-7)/Mas axis), opposing AT1-driven vasoconstriction and fibrosis in preclinical cardiovascular models. AVE0991 is a non-peptide Mas agonist used as a research tool.
Origin
Synthetic Mas-receptor agonist (AVE0991 is non-peptide).
Targets
Studies
- The nonpeptide angiotensin-(1-7) mimic AVE0991 attenuates neuroendocrine and behavioral responses to chronic unpredictable stress
- Angiotensin 1-7 and the Non-Peptide MAS-R Agonist AVE0991 Inhibit Breast Cancer Cell Migration and Invasion
- PNA5, a glycosylated angiotensin-(1-7) mas receptor agonist for vascular dementia: A two species toxicology and toxicokinetic study
- PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia
- AVE0991 ameliorates dopaminergic neuronal damage in Parkinson's disease through HOTAIRM1/miR-223-3p/ฮฑ-synuclein axis
Regulatory & research status
Angiotensin (1-7) Analog is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Research-Only |
Benefits
Angiotensin (1-7) Analog side effects
Side Effects
- Limited human data
- Hypotension possible in models
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freezeโthaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution โ
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544โ575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Angiotensin (1-7) Analog: frequently asked questions
What is Angiotensin (1-7) Analog?
Synthetic Mas-receptor agonist related to angiotensin-(1-7) biology, studied in cardiometabolic and fibrosis models. Not FDA-approved.
How does Angiotensin (1-7) Analog work?
Activates the Mas receptor (ACE2/Ang-(1-7)/Mas axis), opposing AT1-driven vasoconstriction and fibrosis in preclinical cardiovascular models. AVE0991 is a non-peptide Mas agonist used as a research tool.
Is Angiotensin (1-7) Analog FDA approved?
No. Angiotensin (1-7) Analog is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What is the half-life of Angiotensin (1-7) Analog?
Reported half-life for Angiotensin (1-7) Analog is Short; orally active analog tested in rodents. Half-life describes how long the compound persists in circulation, not how long any effect lasts, and published figures vary with route of administration, formulation and the population studied.
What peptides are similar to Angiotensin (1-7) Analog?
Compounds most often compared with Angiotensin (1-7) Analog include 5-Amino-1MQ, Adipotide, AICAR and AOD-9604. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- The nonpeptide angiotensin-(1-7) mimic AVE0991 attenuates neuroendocrine and behavioral responses to chronic unpredictable stress โ Psychopharmacology (Berl), 2026External reference
- Angiotensin 1-7 and the Non-Peptide MAS-R Agonist AVE0991 Inhibit Breast Cancer Cell Migration and Invasion โ Biomedicines, 2025External reference
- PNA5, a glycosylated angiotensin-(1-7) mas receptor agonist for vascular dementia: A two species toxicology and toxicokinetic study โ Toxicol Rep, 2025External reference
- PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia โ Aging Dis, 2024External reference
- AVE0991 ameliorates dopaminergic neuronal damage in Parkinson's disease through HOTAIRM1/miR-223-3p/ฮฑ-synuclein axis โ Sci Rep, 2024External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial ยท Reviewed Aug 30, 2026 ยท Updated Aug 30, 2026 ยท Version 2
This Angiotensin (1-7) Analog profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy ยท How profiles are compiled ยท Report an error
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