Angiotensin (1-7) Analog
Fat LossMas receptor agonist / researchExperimental
Synthetic Mas-receptor agonist related to angiotensin-(1-7) biology, studied in cardiometabolic and fibrosis models. Not FDA-approved.
For research use only.
Key Facts
- CAS
- 284038-60-4
- Molecular Weight (MW)
- 902.0 g/mol
- Half-life
- Short; orally active analog tested in rodents
- Unit
- mcg
- Administration Route
- —
- Frequency
- —
- Last updated
- 8/23/2026
- Targets
- Mas receptor (MAS1)
Overview
Synthetic Mas-receptor agonist related to angiotensin-(1-7) biology, studied in cardiometabolic and fibrosis models. Not FDA-approved.
Protocol
- Dosage Range
- Per research protocol
- Frequency
- —
- Cycle
- —
- Administration Route
- —
- Reconstitution Guide
- —
Science
Mechanism of Action
Activates the Mas receptor (ACE2/Ang-(1-7)/Mas axis), opposing AT1-driven vasoconstriction and fibrosis in preclinical cardiovascular models. AVE0991 is a non-peptide Mas agonist used as a research tool.
Targets
Mas receptor (MAS1)
Studies
- AVE0991 Mas receptor agonist review— Journal/year not available
Benefits
Cardiometabolic pathway researchAnti-fibrotic models
Potential Side Effects
- Limited human data
- Hypotension possible in models
References
- PMID 15475530External link · Year —