Adipotide
Also known as: FTPP, Prohibitin-targeting peptide
Adipotide (also called FTPP or Prohibitin-targeting peptide) is an experimental fat-vasculature targeting peptide in the Targeted peptidomimetic class. Adipotide is a peptidomimetic built from two functional parts joined together. The first is the homing sequence CKGGRAKDC, selected by phage display for binding prohibitin, a protein reported to be selectively displayed on the surface of endothelial cells in white adipose tissue vasculature.
For research use only.
Key Facts
- CAS
- 859216-15-2
- Molecular Weight (MW)
- 2557.2 g/mol
- Half-life
- โ
- FDA status
- Not Approved
- Administration Route
- Research parenteral (historical studies)
- Frequency
- โ
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
- Targets
- Prohibitin (adipose vasculature)
Vendor price snapshot
Price per mg is list price divided by vial size in milligrams when both are known from public vendor listings. Peptide Library does not sell peptides. Confirm live prices on the vendor site.
- Vendors listing this peptide
- 1
- Listed offers
- 1
- Price per mg range
- $8.00/mg
Research summary
Experimental chimeric peptide designed to induce apoptosis in white-adipose vasculature via prohibitin targeting. Not FDA-approved; development did not yield a drug.
Peptide Library's Adipotide profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- Not established for humans
- Frequency
- โ
- Cycle
- โ
- Administration Route
- Research parenteral (historical studies)
- Reconstitution Guide
- โ
- Injection Sites
- AbdomenThigh
- Timing Notes
- Educational catalog only โ not medical advice
Not yet checked against primary sources
These figures are compiled from earlier reference material. They have not been verified against FDA labelling, registered trials or published literature, no citation is attached to them, and none of them is a recommended dose. Adipotide is queued for dosage evidence review.
Compare reported doses across the whole librarySequence & molecular data
| Molecular formula | C111H206N36O28S2 |
|---|---|
| Molecular weight | 2557.2 g/mol |
| CAS number | 859216-15-2 |
| Appearance | White lyophilized powder |
| Formulation | Lyophilized Powder |
| PubChem CID | 163360068 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
Adipotide is a peptidomimetic built from two functional parts joined together. The first is the homing sequence CKGGRAKDC, selected by phage display for binding prohibitin, a protein reported to be selectively displayed on the surface of endothelial cells in white adipose tissue vasculature. The second is a KLAKLAK dimer, a pro-apoptotic domain that is inactive outside cells but disrupts mitochondrial membranes once internalised. The design intent is targeted ablation of the blood supply to fat tissue rather than any action on adipocyte metabolism, causing adipose tissue to regress through loss of perfusion. In primate studies this produced weight reduction, but renal toxicity was observed, and development did not proceed.
Origin
Synthetic targeted peptidomimetic.
Targets
Studies
- Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-ฮฒ pathways
- Fatty Liver/Adipose Tissue Dual-Targeting Nanoparticles with Heme Oxygenase-1 Inducer for Amelioration of Obesity, Obesity-Induced Type 2 Diabetes, and Steatohepatitis
- A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication
- Comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys"
- A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys
Regulatory & research status
Adipotide is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Availability | Research-Only |
| WADA (sport) | Banned in Sport |
| Library classification | Research-Only |
Benefits
Potential Side Effects
Side Effects
- Renal toxicity signal in animals
- No human dose
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freezeโthaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution โ
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544โ575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Adipotide: frequently asked questions
What is Adipotide?
Experimental chimeric peptide designed to induce apoptosis in white-adipose vasculature via prohibitin targeting. Not FDA-approved; development did not yield a drug.
How does Adipotide work?
Adipotide is a peptidomimetic built from two functional parts joined together. The first is the homing sequence CKGGRAKDC, selected by phage display for binding prohibitin, a protein reported to be selectively displayed on the surface of endothelial cells in white adipose tissue vasculature.
Is Adipotide FDA approved?
No. Adipotide is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
Is Adipotide banned in sport?
Adipotide is recorded here as prohibited in sport. Athletes subject to anti-doping rules should check the current WADA Prohibited List directly, since it is revised annually and classifications change.
What peptides are similar to Adipotide?
Compounds most often compared with Adipotide include 5-Amino-1MQ, AICAR, Angiotensin (1-7) Analog and AOD-9604. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- WADA Prohibited List 2026External reference
- Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-ฮฒ pathways โ J Ovarian Res, 2017External reference
- Fatty Liver/Adipose Tissue Dual-Targeting Nanoparticles with Heme Oxygenase-1 Inducer for Amelioration of Obesity, Obesity-Induced Type 2 Diabetes, and Steatohepatitis โ Adv Sci (Weinh), 2022External reference
- A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication โ J Control Release, 2013External reference
- Comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys" โ Sci Transl Med, 2012External reference
- A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys โ Sci Transl Med, 2011External reference
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Compiled by Peptide Library Editorial ยท Reviewed Aug 30, 2026 ยท Updated Aug 30, 2026 ยท Version 1
This Adipotide profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy ยท How profiles are compiled ยท Report an error
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