Peptide Library

Human study PLS-00195

Thymosin β 4 in colorectal cancer is localized predominantly at the invasion front in tumor cells undergoing epithelial mesenchymal transition.

Case series · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Thymosin β 4 in colorectal cancer is localized predominantly at the invasion front in tumor cells undergoing epithelial mesenchymal transition.primary · Cancer biology & therapy · 2012-02-15 · PMID 22233609 · DOI

Design and participants

Design
Case series
Population
Archived intestinal biopsies: colorectal adenocarcinomas with features of epithelial-mesenchymal transition, plus normal colorectal mucosa samples. Frozen surgical specimens from four colon cancer cases were used for mRNA analysis.
Conditions
Colorectal adenocarcinoma
Setting
Retrospective analysis of pathology biopsy specimens
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported
Funding
Research Support, Non-U.S. Gov't (publication type only; funder not named)

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety, and how safety was monitored isn’t described.

    The authors concluded (paraphrased): Tβ4 is expressed in most colon cancers, mainly in deep tumor regions and at the invasion front. This suggests a link with epithelial-mesenchymal transition and a possible role in colorectal cancer invasion and metastasis.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: The study measured endogenous peptide expression in tumor tissue. No participant received the compound.
    • abstract only: Only the PubMed abstract is available in the record. Full methods and results are not provided.
    • small or imprecise: Only 10 normal mucosa samples and 4 cases for mRNA analysis, and the abstract reports no formal estimates.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • author_conclusion: PMID 22233609, abstract (Conclusions, sentences 1-2) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 22233609, abstract (Methods and results, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • funding: PMID 22233609, title (publication types metadata) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 22233609, abstract (Methods and results, sentences 1-3) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).