Peptide Library

Human study PLS-00154

Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis.

Cross-sectional study · Not reported participants enrolled · not included in the assessments (other)

Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis.primary · Molecular vision · 2006-12-20 · PMID 17200658

Design and participants

Design
Cross-sectional study
Population
Patients with vernal keratoconjunctivitis and sex/age-matched healthy subjects providing conjunctival tissue
Conditions
Vernal keratoconjunctivitis
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported
Funding
Research Support, Non-U.S. Gov't (publication type); funder not named in record

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not applicable; no compound was administered.

    The authors concluded (paraphrased): First evidence of Tβ4 expression in conjunctiva. Upregulated stromal Tβ4 mRNA and protein, localized in eosinophils and myofibroblasts in VKC lesions, suggest a possible role in inflammation and tissue remodeling in VKC.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • inappropriate endpoint: Measures endogenous Tβ4 tissue expression only; no administration of the compound and no clinical outcomes.
    • small or imprecise: Only seven VKC patients and five healthy subjects provided tissue, with no statistics reported in the abstract.
    • abstract only: Only the PubMed abstract is available, so methods and quantitative results cannot be verified.
    • other: No thymosin beta-4 was administered. The study measures endogenous expression, so it cannot inform treatment effects or safety.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 17200658, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 17200658, abstract (Conclusions, sentences 1-2) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 17200658, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 17200658, abstract (Methods and Results) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 17200658, abstract (Methods, sentences 1-2) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 17200658, abstract (Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 17200658, abstract (Purpose, sentence 2; Methods, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 17200658, abstract (Results, sentences 1-3) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).