Peptide Library

Human study PLS-00153

Endogenous Thymosin β4 Expression in Sacrococcygeal Pilonidal Sinus Disease: A Retrospective, Immunohistochemical Analysis of Excisional Skin Biopsy Samples.

Case series · 31 participants enrolled · not included in the assessments (other)

Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Endogenous Thymosin β4 Expression in Sacrococcygeal Pilonidal Sinus Disease: A Retrospective, Immunohistochemical Analysis of Excisional Skin Biopsy Samples.primary · Ostomy/wound management · 2017-04-01 · PMID 28448267

Design and participants

Design
Case series
Population
Patients with sacrococcygeal pilonidal sinus disease who underwent excision with primary surgical closure (mean age 26.0 years; 25 men, 6 women)
Conditions
Sacrococcygeal pilonidal sinus disease
Setting
Retrospective analysis of excisional skin biopsy specimens and electronic medical records; institution not stated
Planned enrollment (registry)
Not reported
Enrolled
31
Randomized
Not reported
Completed follow-up
Not reported
Funding
not stated
Authors’ conflicts
not stated

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not applicable; no compound was administered and no safety data were reported.

    The authors concluded (paraphrased): Tβ4 is expressed endogenously in normal skin and is overexpressed in inflamed sinus tract tissue in pilonidal sinus disease. The authors call for further preclinical study of its role and therapeutic potential in dermal healing.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • inappropriate endpoint: The only outcome is endogenous Tβ4 staining intensity, a tissue biomarker. No clinical or healing outcome was assessed.
    • other: No participant received Tβ4. The study measures endogenous expression, so it says nothing about effects of administering the compound.
    • small or imprecise: Only 31 specimens from a single retrospective series were analyzed.
    • inadequate blinding: The abstract does not state whether pathologists scoring the semi-quantitative staining were blinded to tissue type.
    • abstract only: Only the PubMed abstract is available. Methods, funding and conflicts cannot be checked.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 28448267, abstract (sentence 5 (two samples per specimen: chronic wound and control groups)) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 28448267, abstract (final two sentences) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 28448267, abstract (sentence 3 (retrospective immunohistochemical analysis)) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 28448267, abstract (methods sentences and sample size sentence) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 28448267, abstract (sentences 6-8 (Tβ4 expression sites and 0-3 scoring)) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 28448267, abstract (sentence on 31 specimens from 31 patients) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 28448267, abstract (sentence on 31 patients' demographics and primary closure) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 28448267, abstract (sentence reporting higher Tβ4 scores in inflamed tissue) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).