Peptide Library

Human study PLS-00126

Low periconceptional maternal serum thymosin alpha 1 levels are associated with blighted pregnancies.

Prospective cohort · 28 participants enrolled · not included in the assessments (other)

Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • Low periconceptional maternal serum thymosin alpha 1 levels are associated with blighted pregnancies.primary · American journal of reproductive immunology (New York, N.Y. : 1989) · 1993-04-01 · PMID 8373526 · DOI

Design and participants

Design
Prospective cohort
Population
Women aged 24 to 38 years in an ovulation induction and in vitro fertilization program who conceived, as shown by positive serum beta hCG, and had known ovulation dates.
Conditions
Spontaneous abortion, Early pregnancy, Infertility treatment (ovulation induction/IVF)
Setting
University hospital ovulation induction and in vitro fertilization program
Planned enrollment (registry)
Not reported
Enrolled
28
Randomized
Not reported
Completed follow-up
Not reported

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety.

    Monitoring: Not applicable; no intervention was administered.

    The authors concluded (paraphrased): Lower maternal serum thymosin alpha 1 levels may be associated with periconceptional endocrine or immune disturbances that precede miscarriage. Thymosin beta 4 levels did not differ between the groups.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • other: No thymosin beta 4 was given. The study only measured endogenous serum levels, so it says nothing about the effects of administering the compound.
    • small or imprecise: Only 28 women were studied, with 9 in the miscarriage group, which limits precision.
    • confounding: The abstract reports no adjustment for confounders such as age or fertility treatment type between viable and aborted pregnancies.
    • abstract only: Only the abstract is available. Numeric results, funding and conflicts of interest are not reported.
    • inappropriate population: Endogenous levels were measured in women with pregnancy loss. No exogenous thymosin beta-4 was given and no dry eye population was studied.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 8373526, abstract (Study design, sentence 4) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 8373526, abstract (Conclusion, sentence 1) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 8373526, abstract (Study design, sentences 3-5) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 8373526, abstract (Study design and Results) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 8373526, abstract (Study design, sentence 3) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 8373526, abstract (Study design, sentences 3-4) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 8373526, abstract (Study design, sentences 1-2) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 8373526, abstract (Results, sentences 1-3) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 8, 2026 · evidence through November 8, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).