Angiotensin II
Angiotensin II is an FDA-approved vasoconstrictor peptide in the Angiotensin Receptor Agonist class. Angiotensin II binds the AT1 receptor on vascular smooth muscle, a Gq-coupled receptor whose activation raises intracellular calcium and produces vasoconstriction. It also stimulates aldosterone release and promotes renal sodium and water retention.
For research use only.
Key Facts
- CAS
- 4474-91-3
- Molecular Weight (MW)
- 1046.2 g/mol
- Half-life
- —
- FDA status
- Approved
- Administration Route
- intravenous
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Research summary
Synthetic form of the endogenous octapeptide hormone, approved to raise blood pressure in adults with septic or other distributive shock.
Peptide Library's Angiotensin II profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- —
- Frequency
- —
- Cycle
- —
- Administration Route
- intravenous
- Reconstitution Guide
- —
Not yet checked against primary sources
These figures are compiled from earlier reference material. They have not been verified against FDA labelling, registered trials or published literature, no citation is attached to them, and none of them is a recommended dose. Angiotensin II is queued for dosage evidence review.
Compare reported doses across the whole librarySequence & molecular data
| Amino acid sequence | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe |
|---|---|
| Molecular formula | C50H71N13O12 |
| Molecular weight | 1046.2 g/mol |
| CAS number | 4474-91-3 |
| PubChem CID | 172198 |
| FDA UNII | M089EFU921 |
| ChEMBL | CHEMBL408403 |
| DrugBank | DB11842 |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
Angiotensin II binds the AT1 receptor on vascular smooth muscle, a Gq-coupled receptor whose activation raises intracellular calcium and produces vasoconstriction. It also stimulates aldosterone release and promotes renal sodium and water retention. Because it acts through a pathway independent of adrenergic receptors, it can raise blood pressure in shock states where catecholamine responsiveness is impaired.
Regulatory & research status
Angiotensin II is an FDA-approved product for specific labelled indications. Approval does not extend to the research contexts described on this page, and approved products are prescription medicines.
| FDA status | Approved |
|---|---|
| Research status | Approved product (see FDA status) |
| Availability | Prescription-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | FDA-Approved |
Benefits
—
Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
Angiotensin II: frequently asked questions
What is Angiotensin II?
Synthetic form of the endogenous octapeptide hormone, approved to raise blood pressure in adults with septic or other distributive shock.
How does Angiotensin II work?
Angiotensin II binds the AT1 receptor on vascular smooth muscle, a Gq-coupled receptor whose activation raises intracellular calcium and produces vasoconstriction. It also stimulates aldosterone release and promotes renal sodium and water retention.
Is Angiotensin II FDA approved?
Yes. Angiotensin II is approved by the FDA, and approved products are prescription medicines. Approval is always for specific indications studied in clinical trials, so an approved status does not mean the compound is approved for every use it is discussed for. Research-chemical material sold under the same name is not the approved product.
What is the amino acid sequence of Angiotensin II?
Angiotensin II has the sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, giving a chain of 8 amino acids. Its molecular formula is C50H71N13O12.
What peptides are similar to Angiotensin II?
Compounds most often compared with Angiotensin II include Cetrorelix, Corticorelin, Cosyntropin and Degarelix. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- Angiotensin II as a Vasopressor for Perioperative Hypotension in Solid Organ Transplant — Biomedicines, 2024External reference
- Angiotensin II-Real-Life Use and Literature Review — Medicina (Kaunas), 2024External reference
- Angiotensin II: A Review of Current Literature — J Cardiothorac Vasc Anesth, 2022External reference
- Roles of angiotensin II as vasopressor in vasodilatory shock — Future Cardiol, 2020External reference
- Angiotensin II in septic shock — J Intensive Care Soc, 2019External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This Angiotensin II profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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