ACE-031
ACE-031 is a soluble activin receptor IIB fusion protein in the Myostatin Inhibitor class. ACE-031 acts as a decoy receptor, binding myostatin and related TGF-beta superfamily ligands in the circulation before they can engage cell-surface activin receptors. Removing that inhibitory signal relieves suppression of muscle growth.
For research use only.
Key Facts
- CAS
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- Molecular Weight (MW)
- —
- Half-life
- —
- FDA status
- Withdrawn / Rejected
- Administration Route
- subcutaneous
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
Vendor price snapshot
Price per mg is list price divided by vial size in milligrams when both are known from public vendor listings. Peptide Library does not sell peptides. Confirm live prices on the vendor site.
- Vendors listing this peptide
- 1
- Listed offers
- 1
- Price per mg range
- $109.99/mg
Research summary
Fusion protein of the activin receptor type IIB extracellular domain with an IgG1 Fc region, developed as a myostatin pathway inhibitor for muscular dystrophy. Clinical development was discontinued after vascular adverse events. Not FDA-approved.
Peptide Library's ACE-031 profile summarises 5 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- —
- Frequency
- —
- Cycle
- —
- Administration Route
- subcutaneous
- Reconstitution Guide
- —
Science
Mechanism of Action
ACE-031 acts as a decoy receptor, binding myostatin and related TGF-beta superfamily ligands in the circulation before they can engage cell-surface activin receptors. Removing that inhibitory signal relieves suppression of muscle growth. Because the receptor domain binds several ligands rather than myostatin alone, off-target effects on vascular and haematological pathways were observed, which is why development stopped.
Studies
- ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus)
- Gel Electrophoretic Detection of Black Market ACE-031
- ACE-031, a Soluble Activin Type IIB Receptor, Increases Muscle Mass and Strength in the Common Marmoset (Callithrix jacchus)
- Soluble Activin Receptor Type IIB Improves Muscle Regeneration Following Crotalus atrox Venom-Induced Damage
- Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation
Regulatory & research status
ACE-031 was withdrawn from the market or rejected for approval. It is not an approved product.
| FDA status | Withdrawn / Rejected |
|---|---|
| Research status | Development discontinued |
| Availability | Research-Only |
| WADA (sport) | Unknown / Not Listed |
| Library classification | Clinical Trial |
Benefits
—
Potential Side Effects
No side effects listed yet for this entry.
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
ACE-031: frequently asked questions
What is ACE-031?
Fusion protein of the activin receptor type IIB extracellular domain with an IgG1 Fc region, developed as a myostatin pathway inhibitor for muscular dystrophy. Clinical development was discontinued after vascular adverse events. Not FDA-approved.
How does ACE-031 work?
ACE-031 acts as a decoy receptor, binding myostatin and related TGF-beta superfamily ligands in the circulation before they can engage cell-surface activin receptors. Removing that inhibitory signal relieves suppression of muscle growth.
Is ACE-031 FDA approved?
No. ACE-031 is not currently FDA-approved. Its development or marketing was discontinued, which can happen for commercial reasons as well as safety or efficacy ones. Any material available today is not an approved product.
What peptides are similar to ACE-031?
Compounds most often compared with ACE-031 include Follistatin-344, GDF-11, MGF and Anamorelin. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus) — PLoS One, 2026External reference
- Gel Electrophoretic Detection of Black Market ACE-031 — Drug Test Anal, 2025External reference
- ACE-031, a Soluble Activin Type IIB Receptor, Increases Muscle Mass and Strength in the Common Marmoset (Callithrix jacchus) — bioRxiv, 2025External reference
- Soluble Activin Receptor Type IIB Improves Muscle Regeneration Following Crotalus atrox Venom-Induced Damage — Toxins (Basel), 2025External reference
- Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation — Reprod Biol Endocrinol, 2024External reference
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This ACE-031 profile is compiled from published literature (5 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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