Peptide Library

Human study PLS-00036

The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes.

Other design · Not reported participants enrolled · not included in the assessments (not human)

Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

Only the abstract was available. Essential methods may be missing, which limits what can be judged.

Reports of this study

Every publication, registration and abstract describing this one study. Participants are counted once.

  • The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes.primary · Journal of clinical medicine · 2019-08-28 · PMID 31466264 · DOI

Design and participants

Design
Other design
Population
Sixty-one type 2 diabetes patients and 53 control subjects who donated leukocytes for ex vivo experiments
Conditions
Type 2 diabetes
Planned enrollment (registry)
Not reported
Enrolled
Not reported
Randomized
Not reported
Completed follow-up
Not reported

Intervention and comparator

What each group received. Related peptides, analogs and combinations are never treated as the compound itself.

    What the authors reported

    As stated in the sources. This is the authors’ account, not Peptide Library’s assessment.

    Adverse events

    None reported. That is not evidence of safety, and how safety was monitored isn’t described.

    The authors concluded (paraphrased): SS-31 appears to have potentially beneficial effects on leukocytes from T2D patients. It modulates oxidative stress and autophagy and ameliorates ER stress.

    Peptide Library’s assessment

    An automated assessment, made by AI separately from the authors’ conclusions and not reviewed by a person. How risk of bias is assessed.

    Limitations

    • inappropriate population: Ex vivo cell experiments on donated leukocytes; no participant received SS-31, so the results do not show clinical effects.
    • inappropriate endpoint: All outcomes are cellular biomarkers (ROS, ER stress, autophagy, adhesion), not patient-important outcomes.
    • abstract only: Only the abstract is available, with no effect sizes, statistics or methods details.
    • other: SS-31 was applied to isolated cells in vitro, so there was no in vivo human exposure and no safety or tolerability data.

    No risk-of-bias assessment has been published for this study’s results.

    Claims this study informs

    Where each value comes from

    • arms: PMID 31466264, abstract (sentences 5 and 10) · extracted by AI (automated, not verified by a person) · abstract only
    • author_conclusion: PMID 31466264, abstract (final sentence) · extracted by AI (automated, not verified by a person) · abstract only
    • design: PMID 31466264, abstract (sentences 2-4) · extracted by AI (automated, not verified by a person) · abstract only
    • limitations: PMID 31466264, abstract (sentences 5-11) · extracted by AI (automated, not verified by a person) · abstract only
    • outcomes: PMID 31466264, abstract (sentences 5-6) · extracted by AI (automated, not verified by a person) · abstract only
    • participants: PMID 31466264, abstract (sentence 3) · extracted by AI (automated, not verified by a person) · abstract only
    • population: PMID 31466264, abstract (sentence 3) · extracted by AI (automated, not verified by a person) · abstract only
    • results: PMID 31466264, abstract (sentences 7-11) · extracted by AI (automated, not verified by a person) · abstract only

    • Version 1 · published November 7, 2026 · evidence through November 7, 2026 · research snapshot 2026.1.1 · methodology ev-1 · Automated assessment by AI (claude-opus-5-5 and claude-sonnet-5-5), not reviewed by a person.

    These assessments describe published research. Records marked automated were produced by AI under the published methodology and have not been reviewed by a person; they can contain errors. None of this is medical advice, not a statement about any product’s safety for human use, and not a regulatory approval. Peptide Library’s vendor and partner relationships play no part in them (editorial independence).