PEG-MGF (PEGylated Mechano Growth Factor)
Also known as: PEGylated MGF, PEG-IGF-1Ec
PEG-MGF (PEGylated Mechano Growth Factor), also called PEGylated MGF or PEG-IGF-1Ec, is a research peptide in the IGF-1 receptor agonist class. PEG-MGF is the mechano growth factor E-peptide with polyethylene glycol attached. Unmodified MGF has a very short circulating half-life, on the order of minutes, because it is small enough for rapid renal clearance and susceptible to proteolysis.
For research use only.
Key Facts
- CAS
- —
- Molecular Weight (MW)
- ≈8–10 kDa (PEG dependent)
- Half-life
- Extended vs native MGF; no validated human PK
- FDA status
- Not Approved
- Administration Route
- —
- Frequency
- —
- Last updated
- Aug 30, 2026
- Reviewed
- Aug 30, 2026
- Targets
- IGF-1 receptorMuscle satellite cells (proposed)
Vendor price snapshot
Each vendor counts once, at the median price per mg of its own listings; the typical range is the middle half of vendors. From public vendor listings collected between Dec 2025 and Sep 2026, so confirm the live price on the vendor site. Peptide Library does not sell peptides.
- Vendors listing this peptide
- 6
- Listed offers
- 7
- Median price per mg
- $19.50/mg
- Typical $18.10–$35.00/mg
Research summary
PEGylated mechano-growth-factor (IGF-1Ec) analog sold for muscle-repair research. Not FDA-approved. WADA S2 (IGF / MGF).
Peptide Library's PEG-MGF (PEGylated Mechano Growth Factor) profile summarises 4 cited studies listed in the Science section, the compound's regulatory status, and research-protocol parameters reported for it. It is a research reference, not medical advice.
Protocol
- Dosage Range
- Not established
- Frequency
- —
- Cycle
- —
- Administration Route
- —
- Reconstitution Guide
- —
- Timing Notes
- Marketed for muscle-repair research; unapproved for humans.
Not yet checked against primary sources
These figures are compiled from earlier reference material. They have not been verified against FDA labelling, registered trials or published literature, no citation is attached to them, and none of them is a recommended dose. PEG-MGF (PEGylated Mechano Growth Factor) is queued for dosage evidence review.
Compare reported doses across the whole librarySequence & molecular data
| Molecular formula | Large PEG-conjugated peptide (varies by manufacturer) |
|---|---|
| Molecular weight | ≈8–10 kDa (PEG dependent) |
| Half-life | Extended vs native MGF; no validated human PK |
| Appearance | White/off-white lyophilized powder |
| Formulation | Lyophilized Powder |
Identifiers link to the public PubChem, FDA Substance Registration (UNII), ChEMBL and DrugBank records for the same entity.
Science
Mechanism of Action
PEG-MGF is the mechano growth factor E-peptide with polyethylene glycol attached. Unmodified MGF has a very short circulating half-life, on the order of minutes, because it is small enough for rapid renal clearance and susceptible to proteolysis. PEGylation increases hydrodynamic radius above the glomerular filtration threshold and shields the peptide from proteases, extending exposure. The underlying rationale is unchanged from MGF: the Ec E-peptide is proposed to activate muscle satellite cells after mechanical loading through a route independent of the IGF-1 receptor. Whether extending systemic exposure to a factor that normally acts locally after injury reproduces the same biology has not been established, and there is no human evidence.
Origin
Synthetic PEGylated IGF-1Ec-related peptide.
Targets
Studies
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration
- Biological activity of the e domain of the IGF-1Ec as addressed by synthetic peptides (class-level evidence)
- The role of mechano-growth factor E peptide in the regulation of osteosarcoma (class-level evidence)
- Insulinlike growth factor-1Ec (MGF) expression in eutopic and ectopic endometrium: characterization of the MGF E-peptide actions in vitro (class-level evidence)
Regulatory & research status
PEG-MGF (PEGylated Mechano Growth Factor) is not an FDA-approved product. It is sold for laboratory research and has no approved medical use.
| FDA status | Not Approved |
|---|---|
| Availability | Research-Only |
| WADA (sport) | Banned in Sport |
| Library classification | Research-Only |
Benefits
PEG-MGF (PEGylated Mechano Growth Factor) side effects
Side Effects
- Unknown PEGylated-peptide AEs
Storage & stability
Lyophilized (freeze-dried) peptide powder is far more stable than the reconstituted solution. Keep sealed vials cold, dry and away from light; long-term storage is typically frozen, with short-term refrigeration for vials in use.
Once reconstituted in bacteriostatic water, keep the solution refrigerated, avoid repeated freeze–thaw cycles and agitation, and label the vial with the reconstitution date and concentration. Discard any solution that turns cloudy or shows particulates.
Degradation rates differ by sequence: peptides containing methionine, cysteine, asparagine or glutamine are more prone to oxidation and deamidation, so shelf life after reconstitution is compound-specific rather than universal.
Read the full guide: how to store peptides before and after reconstitution →
Source: Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544–575. (PMID 20143256). General guidance for research handling; not product-specific instructions.
PEG-MGF (PEGylated Mechano Growth Factor): frequently asked questions
What is PEG-MGF (PEGylated Mechano Growth Factor)?
PEGylated mechano-growth-factor (IGF-1Ec) analog sold for muscle-repair research. Not FDA-approved. WADA S2 (IGF / MGF).
How does PEG-MGF (PEGylated Mechano Growth Factor) work?
PEG-MGF is the mechano growth factor E-peptide with polyethylene glycol attached. Unmodified MGF has a very short circulating half-life, on the order of minutes, because it is small enough for rapid renal clearance and susceptible to proteolysis.
Is PEG-MGF (PEGylated Mechano Growth Factor) FDA approved?
No. PEG-MGF (PEGylated Mechano Growth Factor) is not approved by the FDA for any indication and is categorised as research-only. It has not been reviewed for safety or efficacy as a medicine, and published research should be read as investigation rather than established use.
What is the half-life of PEG-MGF (PEGylated Mechano Growth Factor)?
Reported half-life for PEG-MGF (PEGylated Mechano Growth Factor) is Extended vs native MGF; no validated human PK. Half-life describes how long the compound persists in circulation, not how long any effect lasts, and published figures vary with route of administration, formulation and the population studied.
Is PEG-MGF (PEGylated Mechano Growth Factor) banned in sport?
PEG-MGF (PEGylated Mechano Growth Factor) is recorded here as prohibited in sport. Athletes subject to anti-doping rules should check the current WADA Prohibited List directly, since it is revised annually and classifications change.
What peptides are similar to PEG-MGF (PEGylated Mechano Growth Factor)?
Compounds most often compared with PEG-MGF (PEGylated Mechano Growth Factor) include IGF-1 (overview), Mecasermin, IGF-1 LR3 and IGF-1 DES. They are grouped by shared mechanism or research area rather than by equivalence, and their regulatory status and evidence base differ.
References
- WADA Prohibited List 2026External reference
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration — Front Endocrinol (Lausanne), 2026External reference
- Class-level evidence — Biological activity of the e domain of the IGF-1Ec as addressed by synthetic peptides — Hormones (Athens), 2014External reference
- Class-level evidence — The role of mechano-growth factor E peptide in the regulation of osteosarcoma — Oncol Lett, 2015External reference
- Class-level evidence — Insulinlike growth factor-1Ec (MGF) expression in eutopic and ectopic endometrium: characterization of the MGF E-peptide actions in vitro — Mol Med, 2011External reference
Related research, comparisons & guides
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Compiled by Peptide Library Editorial · Reviewed Aug 30, 2026 · Updated Aug 30, 2026 · Version 1
This PEG-MGF (PEGylated Mechano Growth Factor) profile is compiled from published literature (4 cited studies linked above), public regulatory records and chemical registries. It describes what research reports; it is not medical advice, and nothing here is a dosing recommendation for humans. Peptide Library does not sell peptides. Editorial policy · How profiles are compiled · Report an error
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