Calcitonin Salmon dosage in published studies and labels

These are the doses used for Calcitonin Salmon in FDA labelling and published clinical studies, reported as each source states them, one row per regimen. They describe what was studied or approved for a specific population. They are not a recommendation, and none of them is a dose for any individual.

Research and educational reference only. This is not medical advice, and no figure on this page is a dosing recommendation.

Last checked against primary sources: November 7, 2026

Studied regimens and sources

Calcitonin salmon has FDA-approved human dosages. Miacalcin injection is 100 USP Units a day under the skin or into a muscle for Paget's disease of bone and for postmenopausal osteoporosis, and starts at 4 USP Units/kg every 12 hours for hypercalcemia (up to 8 USP Units/kg every 6 hours). The nasal spray for postmenopausal osteoporosis is one 200-unit spray a day, alternating nostrils.

FDA Approved

Dosage evidence summary for Calcitonin Salmon
Human dosing established	Yes
Route	Subcutaneous · Intramuscular · Intranasal
Frequency	Once daily (Paget's disease, osteoporosis); every 6–12 hours (hypercalcemia)
Duration studied	Continuous for Paget's disease and osteoporosis, re-evaluated periodically
Titration	Hypercalcemia: 4 USP Units/kg every 12 hours; 8 USP Units/kg every 12 hours after 1–2 days if needed; then up to 8 USP Units/kg every 6 hours.
Evidence level	FDA Approved
Last reviewed	2026-11-07

Research-reported dosing

Doses as studied, one row per regimen. Different trials used different regimens; they are listed separately rather than averaged.

Research-reported dosing for Calcitonin Salmon, one row per studied regimen
Study / context	Population	Dose	Route	Frequency	Duration	Outcome studied	Source
FDA label — Miacalcin injection, Paget's disease of boneFDA-approved label · FDA prescribing information	Adults with symptomatic Paget's disease of bone when alternative treatments are not suitable	100 USP Units (0.5 mL)	Subcutaneous or intramuscular	Once daily	Continuous, re-evaluated periodically	Treatment of Paget's disease	MIACALCIN (calcitonin salmon) injection — FDA prescribing information, DailyMed
FDA label — Miacalcin injection, hypercalcemiaFDA-approved label · FDA prescribing information	Patients with hypercalcemia	Start 4 USP Units/kg; may increase to 8 USP Units/kg every 12 hours, then to a maximum of 8 USP Units/kg every 6 hours	Subcutaneous or intramuscular	Every 12 hours, up to every 6 hours	Early treatment of hypercalcemia	Lower serum calcium	MIACALCIN (calcitonin salmon) injection — FDA prescribing information, DailyMed
FDA label — Miacalcin injection, postmenopausal osteoporosisFDA-approved label · FDA prescribing information	Women more than 5 years past menopause with osteoporosis when alternative treatments are not suitable	100 USP Units (0.5 mL)	Subcutaneous or intramuscular	Once daily	Continuous, with calcium and vitamin D	Treatment of postmenopausal osteoporosis; fracture reduction not demonstrated	MIACALCIN (calcitonin salmon) injection — FDA prescribing information, DailyMed
FDA label — calcitonin salmon nasal spray (generic, Apotex), postmenopausal osteoporosisFDA-approved label · FDA prescribing information, generic	Women more than 5 years past menopause with osteoporosis when alternative treatments are not suitable	1 spray (200 USP Units)	Intranasal, alternating nostrils daily	Once daily	Continuous, with calcium and vitamin D	Treatment of postmenopausal osteoporosis; fracture reduction not demonstrated	Calcitonin salmon nasal spray (Apotex) — FDA prescribing information, DailyMed

Where sources disagree

Doses are in USP Units, not micrograms, and injected and nasal doses differ (100 units injected versus 200 units sprayed). DailyMed lists no current brand-name nasal spray; the nasal row uses a generic label.
The labels report a higher rate of malignancy with calcitonin salmon than placebo in a meta-analysis of 21 trials (4.1% versus 2.9%), so they say to re-evaluate the need for continued therapy periodically.