how much weight should a preprint carry?
Preprints show up more and more and I don't have a settled view.
For: peer review is slow, isn't a strong filter for the problems that actually matter here, and plenty of published work is poor. A preprint is readable in full, which is more than you can say for a lot of paywalled papers.
Against: no external check at all, and the failure modes peer review does catch are real even if it misses others.
Where I've landed provisionally: read a preprint exactly as you'd read a published paper, check the methods yourself, and note that nobody else has. Which is roughly how you should read published work anyway. A preprint occupies whatever tier its design would occupy if published, in vitro stays in vitro, a randomized human trial stays a randomized human trial. The tier is set by the study not the venue. Disagree?