Peptide LibraryResearch statistics
Thyrotropin Alfa research: publications and trials
At a glance
Publications, all years
584
Since 1991
Publications in 2026 so far
10
Through November 1, 2026
Human clinical research
71.3%
414 of 581 classified
Registered clinical trials
26
ClinicalTrials.gov
Randomized controlled trials
41
Publications reporting an RCT in people
Systematic reviews and meta-analyses
15
Preclinical studies
10.0%
27 animal · 27 in vitro · 4 computational
Records that only mention it
115
Not counted above
Status in the library: FDA-approved. 3 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Thyrotropin Alfa publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1991 | 0 | 2 | 0 | 0 | 2 |
| 1993 | 0 | 2 | 0 | 0 | 2 |
| 1994 | 1 | 1 | 0 | 0 | 2 |
| 1995 | 0 | 3 | 0 | 0 | 3 |
| 1996 | 1 | 1 | 0 | 0 | 2 |
| 1997 | 1 | 0 | 0 | 0 | 1 |
| 1998 | 0 | 1 | 1 | 1 | 3 |
| 1999 | 3 | 0 | 7 | 2 | 12 |
| 2000 | 11 | 1 | 3 | 0 | 15 |
| 2001 | 15 | 0 | 2 | 1 | 18 |
| 2002 | 14 | 2 | 1 | 0 | 17 |
| 2003 | 25 | 1 | 4 | 1 | 31 |
| 2004 | 16 | 1 | 2 | 1 | 20 |
| 2005 | 16 | 1 | 3 | 2 | 22 |
| 2006 | 24 | 3 | 4 | 0 | 31 |
| 2007 | 16 | 1 | 5 | 0 | 22 |
| 2008 | 20 | 3 | 6 | 1 | 30 |
| 2009 | 25 | 4 | 6 | 0 | 35 |
| 2010 | 22 | 6 | 4 | 0 | 32 |
| 2011 | 22 | 2 | 4 | 1 | 29 |
| 2012 | 22 | 1 | 8 | 8 | 39 |
| 2013 | 12 | 6 | 5 | 4 | 27 |
| 2014 | 16 | 1 | 6 | 0 | 23 |
| 2015 | 19 | 1 | 1 | 1 | 22 |
| 2016 | 14 | 2 | 1 | 0 | 17 |
| 2017 | 10 | 2 | 1 | 0 | 13 |
| 2018 | 15 | 1 | 0 | 1 | 17 |
| 2019 | 11 | 0 | 1 | 0 | 12 |
| 2020 | 11 | 0 | 1 | 0 | 12 |
| 2021 | 16 | 1 | 2 | 1 | 20 |
| 2022 | 7 | 0 | 2 | 1 | 10 |
| 2023 | 8 | 2 | 2 | 0 | 12 |
| 2024 | 7 | 2 | 2 | 0 | 11 |
| 2025 | 5 | 4 | 1 | 0 | 10 |
| 2026 (to date) | 9 | 0 | 1 | 0 | 10 |
Study types
| Observational human study | 179 |
|---|---|
| Other clinical trial | 139 |
| Review | 71 |
| Case report | 55 |
| Randomized controlled trial | 41 |
| Animal study | 27 |
| In vitro study | 27 |
| Editorial, letter or other | 21 |
| Meta-analysis | 13 |
| Computational study | 4 |
| Not yet classified | 3 |
| Systematic review | 2 |
| Guideline or consensus | 1 |
| Correction or retraction notice | 1 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Endocrinology | 557 |
|---|---|
| Oncology | 438 |
| Musculoskeletal | 19 |
| Cardiovascular | 12 |
| Metabolic health | 12 |
| Neurological and mental health | 12 |
| Immune system | 10 |
| Reproductive and sexual health | 10 |
| Obesity and weight management | 6 |
| Tissue repair | 6 |
| Longevity and aging | 4 |
| Gastrointestinal | 3 |
Registered clinical trials
6 of 14 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 20 · Unknown status: 3 · Recruiting: 2 · Active, not recruiting: 1
Early phase 1: 1 · Phase not applicable: 4 · Phase 1: 2 · Phase 1 / Phase 2: 2 · Phase 2: 8 · Phase 3: 7 · Phase 4: 2
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Medium- and long-term recurrence after radioiodine therapy for differentiated thyroid carcinoma with recombinant human thyrotropin: a meta-analysis.
Frontiers in endocrinology · December 17, 2024 · Meta-analysis · cited 4 times · open access
PMID 39741877 · DOI 10.3389/fendo.2024.1474121 · Reviews and meta-analyses
- Comparison of Recombinant Human Thyroid-Stimulating Hormone and Thyroid Hormone Withdrawal for 131 I Therapy in Patients With Intermediate- to High-Risk Thyroid Cancer : A Systematic Review and Meta-analysis.
Clinical nuclear medicine · January 19, 2024 · Meta-analysis · cited 12 times
PMID 38271262 · DOI 10.1097/rlu.0000000000005022 · Reviews and meta-analyses
- Effect of recombinant human thyroid stimulating hormone on long-term salivary gland dysfunction in thyroid cancer patients treated with radioactive iodine. A systematic review.
Oral oncology · December 14, 2022 · Meta-analysis · cited 7 times
PMID 36525783 · DOI 10.1016/j.oraloncology.2022.106280 · Reviews and meta-analyses
- Recombinant human thyrotropin (rhTSH)-aided radioiodine treatment for non-toxic multinodular goitre.
The Cochrane database of systematic reviews · December 28, 2021 · Meta-analysis · cited 3 times · open access
PMID 34961921 · DOI 10.1002/14651858.cd010622.pub2 · Reviews and meta-analyses
- Recombinant Human Thyrotropin-Stimulated Radioiodine Therapy in Patients with Multinodular Goiters: A Meta-Analysis of Randomized Controlled Trials.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · September 22, 2020 · Meta-analysis · cited 2 times · open access
PMID 32961564 · DOI 10.1055/a-1240-5058 · Reviews and meta-analyses
- Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter.
Nuklearmedizin. Nuclear medicine · August 2, 2016 · Meta-analysis · cited 2 times
PMID 27480576 · DOI 10.3413/nukmed-0808-16-03 · Reviews and meta-analyses
- A Systematic Review of Adjuvant Interventions for Radioiodine in Patients with Thyroid Cancer.
Oncology research and treatment · June 18, 2015 · Meta-analysis · cited 4 times
PMID 26278581 · DOI 10.1159/000433486 · Reviews and meta-analyses
- Recombinant human thyrotropin before (131)I therapy in patients with nodular goitre: a meta-analysis of randomized controlled trials.
Clinical endocrinology · December 29, 2014 · Meta-analysis · cited 16 times
PMID 25370124 · DOI 10.1111/cen.12654 · Reviews and meta-analyses
- The effectiveness of recombinant human thyroid-stimulating hormone versus thyroid hormone withdrawal prior to radioiodine remnant ablation in thyroid cancer: a meta-analysis of randomized controlled trials.
Journal of Korean medical science · May 30, 2014 · Meta-analysis · cited 17 times · open access
PMID 24932083 · DOI 10.3346/jkms.2014.29.6.811 · Reviews and meta-analyses
- Recombinant human thyrotropin versus thyroid hormone withdrawal in radioiodine remnant ablation for differentiated thyroid cancer: a meta-analysis.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · May 21, 2014 · Meta-analysis · cited 6 times
PMID 24844252 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.
The New England journal of medicine · February 1, 2013 · Other clinical trial · cited 844 times · open access
PMID 23406027 · DOI 10.1056/nejmoa1209288 · Human clinical research
- A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism · April 1, 2003 · Review · cited 656 times · open access
PMID 12679418 · DOI 10.1210/jc.2002-021702 · Reviews and meta-analyses
- Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer.
The New England journal of medicine · May 1, 2012 · Randomized controlled trial · cited 615 times · open access
PMID 22551128 · DOI 10.1056/nejmoa1109589 · Human clinical research
- Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study.
The Journal of clinical endocrinology and metabolism · December 29, 2005 · Randomized controlled trial · cited 450 times
PMID 16384850 · DOI 10.1210/jc.2005-1651 · Human clinical research
- Recombinant human thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma.
The Journal of clinical endocrinology and metabolism · August 1, 2003 · Observational human study · cited 428 times · open access
PMID 12915653 · DOI 10.1210/jc.2002-021925 · Human clinical research
Latest publications
- TSH Stimulation Reveals Additional Bone Metastases on [<sup>18</sup>F]FDG PET/CT in Metastatic Follicular Thyroid Carcinoma.
Diagnostics (Basel, Switzerland) · September 28, 2026 · Case report · cited 0 times · open access
PMID 42882301 · DOI 10.3390/diagnostics16193146 · Human clinical research
- Recombinant Human Thyrotropin Versus Thyroid Hormone Withdrawal for Radioactive Iodine Therapy in Metastatic Differentiated Thyroid Cancer: A Multicenter Retrospective Study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine · September 24, 2026 · Observational human study · cited 0 times
PMID 42785948 · DOI 10.2967/jnumed.126.273112 · Human clinical research
- Recombinant human thyrotropin reducing insulin resistance in patients with differentiated thyroid cancer.
Journal of the Endocrine Society · September 3, 2026 · Observational human study · cited 0 times · open access
PMID 42741501 · DOI 10.1210/jendso/bvag208 · Human clinical research
- A Novel Protocol for Pre-Treatment Diagnostic <sup>131</sup>I Scan Within 24 Hours Post-Second rhTSH Administration to Guide Radioiodine Therapy in Differentiated Thyroid Cancer.
Thyroid : official journal of the American Thyroid Association · August 24, 2026 · Observational human study · cited 0 times
PMID 42636095 · DOI 10.1177/10507256261483389 · Human clinical research
- Thyroxine withdrawal prior to radioiodine therapy in papillary thyroid carcinoma - current scenarios.
Current opinion in endocrinology, diabetes, and obesity · August 12, 2026 · Review · cited 0 times
PMID 42590940 · DOI 10.1097/med.0000000000000977 · Reviews and meta-analyses
- Redifferentiation therapy with selpercatinib in RET-fusion-positive advanced thyroid carcinoma: a case report and literature review.
Frontiers in oncology · June 29, 2026 · Case report · cited 1 times · open access
PMID 42444822 · DOI 10.3389/fonc.2026.1819030 · Human clinical research
- Early Side Effects of rhTSH-Aided Radioiodine Ablation and Treatment of Differentiated Thyroid Cancer: A Real-World Experience.
World journal of nuclear medicine · June 4, 2026 · Observational human study · cited 0 times · open access
PMID 42395159 · DOI 10.1055/s-0046-1823122 · Human clinical research
- Single 0.9-mg intramuscular rhTSH dose achieves target TSH levels in differentiated thyroid carcinoma.
Endocrine · June 2, 2026 · Observational human study · cited 0 times · open access
PMID 42228192 · DOI 10.1007/s12020-026-04671-y · Human clinical research
- TSH Stimulation Methods are Associated with Comparable Outcomes in Radioiodine-Avid Metastatic Differentiated Thyroid Cancer: Single Center Retrospective Observational Study.
Thyroid : official journal of the American Thyroid Association · May 14, 2026 · Observational human study · cited 0 times
PMID 42132097 · DOI 10.1177/10507256261448724 · Human clinical research
- Recurrent Orbital Metastases in Follicular Variant Papillary Thyroid Carcinoma After Recombinant Human Thyrotropin.
JCEM case reports · January 14, 2026 · Case report · cited 0 times · open access
PMID 41541842 · DOI 10.1210/jcemcr/luaf320 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: rhTSH; Thyrogen; Thyrotropin Alfa
((TITLE_ABS:"rhTSH" OR CHEM:"rhTSH") OR (TITLE_ABS:"Thyrogen" OR CHEM:"Thyrogen") OR (TITLE_ABS:"Thyrotropin Alfa" OR CHEM:"Thyrotropin Alfa")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Thyrotropin Alfa research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/thyrotropin-alfa