Peptide LibraryResearch statistics
Terlipressin research: publications and trials
At a glance
Publications, all years
1,125
Since 1976
Publications in 2026 so far
32
Through November 1, 2026
Human clinical research
45.8%
502 of 1,097 classified
Registered clinical trials
95
ClinicalTrials.gov
Randomized controlled trials
153
Publications reporting an RCT in people
Systematic reviews and meta-analyses
80
Preclinical studies
10.6%
95 animal · 10 in vitro · 11 computational
Records that only mention it
250
Not counted above
Status in the library: FDA-approved. 28 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Terlipressin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1976 | 1 | 0 | 0 | 0 | 1 |
| 1977 | 1 | 0 | 0 | 0 | 1 |
| 1978 | 1 | 0 | 0 | 0 | 1 |
| 1979 | 1 | 0 | 0 | 0 | 1 |
| 1980 | 4 | 1 | 0 | 1 | 6 |
| 1982 | 2 | 0 | 0 | 1 | 3 |
| 1983 | 0 | 2 | 1 | 0 | 3 |
| 1984 | 1 | 3 | 0 | 0 | 4 |
| 1985 | 3 | 2 | 0 | 1 | 6 |
| 1986 | 6 | 0 | 2 | 3 | 11 |
| 1987 | 4 | 1 | 1 | 1 | 7 |
| 1988 | 4 | 1 | 1 | 0 | 6 |
| 1989 | 6 | 1 | 0 | 1 | 8 |
| 1990 | 10 | 2 | 2 | 0 | 14 |
| 1991 | 5 | 0 | 3 | 0 | 8 |
| 1992 | 3 | 1 | 2 | 0 | 6 |
| 1993 | 7 | 2 | 1 | 1 | 11 |
| 1994 | 4 | 0 | 3 | 2 | 9 |
| 1995 | 2 | 2 | 4 | 2 | 10 |
| 1996 | 8 | 1 | 0 | 2 | 11 |
| 1997 | 6 | 2 | 3 | 2 | 13 |
| 1998 | 3 | 4 | 7 | 1 | 15 |
| 1999 | 7 | 5 | 3 | 3 | 18 |
| 2000 | 6 | 3 | 6 | 1 | 16 |
| 2001 | 5 | 4 | 5 | 2 | 16 |
| 2002 | 12 | 2 | 4 | 3 | 21 |
| 2003 | 9 | 2 | 9 | 4 | 24 |
| 2004 | 19 | 2 | 10 | 4 | 35 |
| 2005 | 10 | 3 | 4 | 4 | 21 |
| 2006 | 15 | 1 | 15 | 4 | 35 |
| 2007 | 19 | 2 | 6 | 9 | 36 |
| 2008 | 15 | 1 | 14 | 4 | 34 |
| 2009 | 17 | 4 | 5 | 11 | 37 |
| 2010 | 23 | 2 | 11 | 2 | 38 |
| 2011 | 20 | 3 | 10 | 7 | 40 |
| 2012 | 13 | 3 | 10 | 4 | 30 |
| 2013 | 18 | 3 | 10 | 1 | 32 |
| 2014 | 11 | 5 | 4 | 7 | 27 |
| 2015 | 19 | 3 | 8 | 3 | 33 |
| 2016 | 14 | 5 | 8 | 6 | 33 |
| 2017 | 16 | 5 | 12 | 6 | 39 |
| 2018 | 12 | 4 | 6 | 10 | 32 |
| 2019 | 19 | 2 | 18 | 10 | 49 |
| 2020 | 16 | 6 | 11 | 10 | 43 |
| 2021 | 13 | 4 | 10 | 11 | 38 |
| 2022 | 13 | 3 | 7 | 5 | 28 |
| 2023 | 18 | 4 | 21 | 17 | 60 |
| 2024 | 18 | 2 | 15 | 27 | 62 |
| 2025 | 25 | 5 | 15 | 16 | 61 |
| 2026 (to date) | 18 | 3 | 5 | 6 | 32 |
Study types
| Review | 212 |
|---|---|
| Editorial, letter or other | 176 |
| Case report | 157 |
| Randomized controlled trial | 153 |
| Observational human study | 110 |
| Animal study | 95 |
| Other clinical trial | 82 |
| Meta-analysis | 55 |
| Not yet classified | 28 |
| Systematic review | 25 |
| Computational study | 11 |
| In vitro study | 10 |
| Guideline or consensus | 7 |
| Correction or retraction notice | 4 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Gastrointestinal | 704 |
|---|---|
| Reproductive and sexual health | 340 |
| Cardiovascular | 294 |
| Immune system | 118 |
| Antimicrobial and infectious disease | 113 |
| Endocrinology | 58 |
| Metabolic health | 52 |
| Tissue repair | 48 |
| Dermatology | 25 |
| Neurological and mental health | 23 |
| Oncology | 15 |
| Musculoskeletal | 10 |
Registered clinical trials
22 of 46 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 49 · Unknown status: 29 · Terminated: 5 · Recruiting: 4 · Not yet recruiting: 3 · Active, not recruiting: 2 · Withdrawn: 2 · Suspended: 1
Phase not applicable: 35 · Phase 1: 2 · Phase 1 / Phase 2: 1 · Phase 2: 15 · Phase 2 / Phase 3: 7 · Phase 3: 16 · Phase 4: 19
The 50 most recently started of 95 trials.
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Continuous Versus Bolus Terlipressin for Acute Oesophageal Variceal Bleeding and Hepatorenal Syndrome in Cirrhosis: Meta-Analysis.
Liver international : official journal of the International Association for the Study of the Liver · April 1, 2026 · Meta-analysis · cited 0 times
PMID 41853888 · DOI 10.1111/liv.70607 · Reviews and meta-analyses
- Efficacy and safety of terlipressin infusion during liver surgery: a meta-analysis.
Updates in surgery · April 16, 2025 · Meta-analysis · cited 1 times · open access
PMID 40240682 · DOI 10.1007/s13304-025-02197-y · Reviews and meta-analyses
- Terlipressin for the treatment of hepatorenal syndrome: a meta-analysis of randomized controlled trials.
European journal of gastroenterology & hepatology · February 27, 2025 · Meta-analysis · cited 3 times
PMID 40207491 · DOI 10.1097/meg.0000000000002954 · Reviews and meta-analyses
- Incidence and type of adverse events in patients with cirrhosis receiving terlipressin: A systematic review and meta-analysis.
Hepatology communications · September 18, 2024 · Meta-analysis · cited 8 times · open access
PMID 39298544 · DOI 10.1097/hc9.0000000000000526 · Reviews and meta-analyses
- The effect of shortening vasoactive drug durations alongside endoscopic therapy in esophageal variceal bleeding: an updated systematic review and meta-analysis.
Annals of gastroenterology · August 19, 2024 · Meta-analysis · cited 1 times · open access
PMID 39238793 · DOI 10.20524/aog.2024.0906 · Reviews and meta-analyses
- Efficacy and safety of terlipressin and albumin vs. noradrenaline and albumin in adult patients with hepatorenal syndrome: A systematic review and meta-analysis.
Annals of hepatology · March 7, 2024 · Meta-analysis · cited 8 times · open access
PMID 38460713 · DOI 10.1016/j.aohep.2024.101495 · Reviews and meta-analyses
- Comparative efficacy of terlipressin and norepinephrine for treatment of hepatorenal syndrome-acute kidney injury: A systematic review and meta-analysis.
PloS one · January 29, 2024 · Meta-analysis · cited 17 times · open access
PMID 38285703 · DOI 10.1371/journal.pone.0296690 · Reviews and meta-analyses
- Vasoconstrictor Therapy for Acute Kidney Injury Hepatorenal Syndrome: A Meta-Analysis of Randomized Studies.
Gastro hep advances · January 18, 2023 · Meta-analysis · cited 10 times · open access
PMID 39132033 · DOI 10.1016/j.gastha.2023.01.007 · Reviews and meta-analyses
- Prophylactic Perioperative Terlipressin Therapy for Preventing Acute Kidney Injury in Living Donor Liver Transplant Recipients: A Systematic Review and Meta-Analysis.
Journal of clinical and experimental hepatology · June 25, 2021 · Meta-analysis · cited 7 times · open access
PMID 35535072 · DOI 10.1016/j.jceh.2021.06.019 · Reviews and meta-analyses
- Vasoactive Agents for the Management of Acute Variceal Bleeding: A Systematic Review and Meta-analysis.
Journal of gastrointestinal and liver diseases : JGLD · March 13, 2021 · Meta-analysis · cited 37 times · open access
PMID 33723542 · DOI 10.15403/jgld-3191 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis.
Gut · March 27, 2007 · Review · cited 1,085 times · open access
PMID 17389705 · DOI 10.1136/gut.2006.107789 · Reviews and meta-analyses
- A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome.
Gastroenterology · February 13, 2008 · Randomized controlled trial · cited 664 times · open access
PMID 18471513 · DOI 10.1053/j.gastro.2008.02.014 · Human clinical research
- Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: results of a prospective, nonrandomized study.
Hepatology (Baltimore, Md.) · October 1, 2002 · Other clinical trial · cited 602 times · open access
PMID 12297842 · DOI 10.1053/jhep.2002.35819 · Human clinical research
- Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study.
Gastroenterology · February 14, 2008 · Randomized controlled trial · cited 601 times
PMID 18471512 · DOI 10.1053/j.gastro.2008.02.024 · Human clinical research
- Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome.
The New England journal of medicine · March 1, 2021 · Randomized controlled trial · cited 484 times · open access
PMID 33657294 · DOI 10.1056/nejmoa2008290 · Human clinical research
Latest publications
- Influence of Albumin Treatment Duration on Outcome of Terlipressin Therapy in Patients With HRS-AKI.
Liver international : official journal of the International Association for the Study of the Liver · November 1, 2026 · Observational human study · cited 0 times · open access
PMID 42813964 · DOI 10.1111/liv.70888 · Human clinical research
- Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · October 2, 2026 · Systematic review · cited 0 times
PMID 42825583 · DOI 10.1097/lvt.0000000000001012 · Reviews and meta-analyses
- Complete Response Durability After TAR-200 and Nadofaragene Firadenovec in BCG-unresponsive Bladder CIS.
Anticancer research · October 1, 2026 · Computational study · cited 0 times
PMID 42823172 · DOI 10.21873/anticanres.18415 · Computational studies
- Clinical Outcomes of Terlipressin Using Continuous Infusion Versus Bolus in Patients With Acute Variceal Hemorrhage-A Randomized Controlled Trial: Erratum.
Journal of clinical gastroenterology · October 1, 2026 · Editorial, letter or other · cited 0 times
PMID 42693530 · DOI 10.1097/mcg.0000000000002430 · Commentary and other
- Acute variceal bleeding in a patient with phaeochromocytoma: the critical choice of vasoactive therapy.
BMJ case reports · September 30, 2026 · Case report · cited 0 times
PMID 42816107 · DOI 10.1136/bcr-2026-272756 · Human clinical research
- Correction to "Terlipressin Therapy for Portal Hyperperfusion Secondary to Portal Vein Size Discrepancy After Pediatric Liver Transplant".
Pediatric transplantation · September 1, 2026 · Correction or retraction notice · cited 0 times · open access
PMID 42746863 · DOI 10.1111/petr.70399 · Notices
- Nonintensive Care Unit Norepinephrine as an Alternative to Terlipressin in Hepatorenal Syndrome-Acute Kidney Injury.
Gastro hep advances · August 12, 2026 · Observational human study · cited 0 times · open access
PMID 42757064 · DOI 10.1016/j.gastha.2026.101096 · Human clinical research
- Real-world safety of terlipressin in elderly patients with liver cirrhosis and esophagogastric variceal bleeding: a focus on hyponatremia and administration methods.
Frontiers in pharmacology · August 3, 2026 · Observational human study · cited 0 times · open access
PMID 42609465 · DOI 10.3389/fphar.2026.1861406 · Human clinical research
- Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.
The Analyst · July 27, 2026 · In vitro study · cited 0 times
PMID 42328738 · DOI 10.1039/d6an00455e · In vitro studies
- Evaluation of Terlipressin and In-Hospital Mortality in the Treatment of Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI).
The Annals of pharmacotherapy · July 25, 2026 · Observational human study · cited 0 times · open access
PMID 42500941 · DOI 10.1177/10600280261467017 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Glypressin; Lucassin; Terlipresina; Terlipressin; Terlipressina; Terlipressine; Terlivaz; Triglycyl lysine vasopressin; Variquel
((TITLE_ABS:"Glypressin" OR CHEM:"Glypressin") OR (TITLE_ABS:"Lucassin" OR CHEM:"Lucassin") OR (TITLE_ABS:"Terlipresina" OR CHEM:"Terlipresina") OR (TITLE_ABS:"Terlipressin" OR CHEM:"Terlipressin") OR (TITLE_ABS:"Terlipressina" OR CHEM:"Terlipressina") OR (TITLE_ABS:"Terlipressine" OR CHEM:"Terlipressine") OR (TITLE_ABS:"Terlivaz" OR CHEM:"Terlivaz") OR (TITLE_ABS:"Triglycyl lysine vasopressin" OR CHEM:"Triglycyl lysine vasopressin") OR (TITLE_ABS:"Variquel" OR CHEM:"Variquel")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Terlipressin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/terlipressin