Peptide LibraryResearch statistics
Teduglutide research: publications and trials
At a glance
Publications, all years
339
Since 2000
Publications in 2026 so far
33
Through November 1, 2026
Human clinical research
47.3%
160 of 338 classified
Registered clinical trials
41
ClinicalTrials.gov
Randomized controlled trials
26
Publications reporting an RCT in people
Systematic reviews and meta-analyses
9
Preclinical studies
20.1%
42 animal · 16 in vitro · 10 computational
Records that only mention it
40
Not counted above
Status in the library: FDA-approved. 1 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Teduglutide publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 2000 | 0 | 1 | 0 | 0 | 1 |
| 2001 | 0 | 1 | 1 | 0 | 2 |
| 2004 | 0 | 1 | 0 | 0 | 1 |
| 2005 | 1 | 0 | 0 | 0 | 1 |
| 2006 | 0 | 0 | 3 | 0 | 3 |
| 2007 | 0 | 1 | 0 | 0 | 1 |
| 2008 | 1 | 1 | 1 | 1 | 4 |
| 2009 | 0 | 1 | 3 | 0 | 4 |
| 2010 | 1 | 1 | 1 | 0 | 3 |
| 2011 | 2 | 1 | 4 | 0 | 7 |
| 2012 | 4 | 3 | 4 | 1 | 12 |
| 2013 | 4 | 1 | 7 | 4 | 16 |
| 2014 | 1 | 2 | 6 | 2 | 11 |
| 2015 | 5 | 2 | 4 | 1 | 12 |
| 2016 | 5 | 2 | 2 | 2 | 11 |
| 2017 | 5 | 5 | 6 | 3 | 19 |
| 2018 | 7 | 6 | 4 | 0 | 17 |
| 2019 | 15 | 1 | 8 | 2 | 26 |
| 2020 | 12 | 12 | 4 | 2 | 30 |
| 2021 | 9 | 5 | 2 | 1 | 17 |
| 2022 | 8 | 7 | 7 | 1 | 23 |
| 2023 | 16 | 4 | 4 | 2 | 26 |
| 2024 | 25 | 2 | 3 | 0 | 30 |
| 2025 | 20 | 4 | 4 | 1 | 29 |
| 2026 (to date) | 19 | 4 | 5 | 5 | 33 |
Study types
| Review | 74 |
|---|---|
| Observational human study | 65 |
| Case report | 55 |
| Animal study | 42 |
| Randomized controlled trial | 26 |
| Editorial, letter or other | 21 |
| In vitro study | 16 |
| Other clinical trial | 14 |
| Computational study | 10 |
| Guideline or consensus | 5 |
| Meta-analysis | 5 |
| Systematic review | 4 |
| Correction or retraction notice | 1 |
| Not yet classified | 1 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Gastrointestinal | 310 |
|---|---|
| Metabolic health | 27 |
| Endocrinology | 19 |
| Immune system | 16 |
| Oncology | 15 |
| Neurological and mental health | 13 |
| Obesity and weight management | 9 |
| Tissue repair | 7 |
| Cardiovascular | 4 |
| Reproductive and sexual health | 3 |
| Antimicrobial and infectious disease | 2 |
Registered clinical trials
12 of 35 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 36 · Active, not recruiting: 1 · Not yet recruiting: 1 · Recruiting: 1 · Unknown status: 1 · Withdrawn: 1
Early phase 1: 1 · Phase not applicable: 6 · Phase 1: 6 · Phase 2: 6 · Phase 2 / Phase 3: 3 · Phase 3: 17 · Phase 4: 2
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Positive clinical outcomes associated with use of glucagon-like peptide-2 (GLP-2) analogues in patients with intestinal failure: A systematic review and meta-analysis.
Clinical nutrition ESPEN · December 2, 2025 · Meta-analysis · cited 4 times
PMID 41344401 · DOI 10.1016/j.clnesp.2025.11.132 · Reviews and meta-analyses
- Impact of teduglutide on pediatric short bowel syndrome: A systematic review and trial sequential meta-analysis.
World journal of gastrointestinal surgery · December 1, 2025 · Meta-analysis · cited 1 times · open access
PMID 41479721 · DOI 10.4240/wjgs.v17.i12.112685 · Reviews and meta-analyses
- [Review of real-life teduglutide experience].
Nutricion hospitalaria · August 1, 2023 · Meta-analysis · cited 0 times · open access
PMID 37409717 · DOI 10.20960/nh.04646 · Reviews and meta-analyses
- Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis.
Nutrients · February 14, 2022 · Meta-analysis · cited 64 times · open access
PMID 35215445 · DOI 10.3390/nu14040796 · Reviews and meta-analyses
- Population pharmacokinetics of teduglutide following repeated subcutaneous administrations in healthy participants and in patients with short bowel syndrome and Crohn's disease.
Journal of clinical pharmacology · September 22, 2009 · Meta-analysis · cited 46 times
PMID 19773525 · DOI 10.1177/0091270009342252 · Reviews and meta-analyses
- Efficacy and safety of glucagon-like peptide 2 in patients with short bowel syndrome: a systematic review and network meta-analysis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · April 23, 2024 · Systematic review · cited 13 times
PMID 38663565 · DOI 10.1016/j.gassur.2024.04.009 · Reviews and meta-analyses
- Use of Teduglutide in Children With Intestinal Failure: A Systematic Review.
Frontiers in nutrition · June 14, 2022 · Systematic review · cited 32 times · open access
PMID 35774551 · DOI 10.3389/fnut.2022.866518 · Reviews and meta-analyses
- Glucagon like peptide-2 and neoplasia; a systematic review.
Expert review of gastroenterology & hepatology · December 19, 2017 · Systematic review · cited 39 times
PMID 29231791 · DOI 10.1080/17474124.2018.1417032 · Reviews and meta-analyses
- Teduglutide for Safe Reduction of Parenteral Nutrient and/or Fluid Requirements in Adults: A Systematic Review.
JPEN. Journal of parenteral and enteral nutrition · April 16, 2015 · Systematic review · cited 34 times
PMID 25883117 · DOI 10.1177/0148607115582063 · Reviews and meta-analyses
- Quality of life for pediatric patients with short bowel syndrome-associated intestinal failure treated with teduglutide.
Journal of pediatric gastroenterology and nutrition · March 19, 2026 · Randomized controlled trial · cited 0 times · open access
PMID 41858082 · DOI 10.1002/jpn3.70358 · Human clinical research
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure.
Gastroenterology · September 11, 2012 · Randomized controlled trial · cited 505 times · open access
PMID 22982184 · DOI 10.1053/j.gastro.2012.09.007 · Human clinical research
- Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients.
Gut · September 1, 2005 · Other clinical trial · cited 469 times · open access
PMID 16099790 · DOI 10.1136/gut.2004.061440 · Human clinical research
- Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.
Gut · February 11, 2011 · Randomized controlled trial · cited 461 times · open access
PMID 21317170 · DOI 10.1136/gut.2010.218271 · Human clinical research
- Intestinal adaptation following resection.
JPEN. Journal of parenteral and enteral nutrition · February 28, 2014 · Review · cited 262 times
PMID 24586019 · DOI 10.1177/0148607114525210 · Reviews and meta-analyses
- Long-Term Teduglutide for the Treatment of Patients With Intestinal Failure Associated With Short Bowel Syndrome.
Clinical and translational gastroenterology · February 4, 2016 · Other clinical trial · cited 225 times · open access
PMID 26844839 · DOI 10.1038/ctg.2015.69 · Human clinical research
Latest publications
- Diffuse gallbladder epithelial proliferation after teduglutide exposure: A case report.
JPGN reports · October 28, 2026 · Case report · cited 0 times · open access
PMID 42953361 · DOI 10.1002/jpr3.70284 · Human clinical research
- Characteristics associated with response to teduglutide in pediatric short bowel syndrome-associated intestinal failure: Post hoc analysis of open-label long-term extension trials.
Intestinal Failure (New York, N.Y.) · October 21, 2026 · Other clinical trial · cited 0 times · open access
PMID 42960027 · DOI 10.1016/j.intf.2026.100398 · Human clinical research
- Gut-derived glucagon-like peptides attenuate T cell-induced intestinal injury.
Cell reports. Medicine · October 20, 2026 · Animal study · cited 0 times
PMID 42901164 · DOI 10.1016/j.xcrm.2026.103115 · Animal studies
- Novel variant and enteroendocrine hormone deficiency in a patient with proline and glutamate-rich protein with a coiled coil domain 1 (PERCC1) associated enteropathy: New diagnostic and therapeutic insights.
JPGN reports · October 16, 2026 · Case report · cited 0 times · open access
PMID 42890435 · DOI 10.1002/jpr3.70259 · Human clinical research
- Teduglutide for intestinal failure following multivisceral transplantation complicated by graft rejection and PTLD: A case report.
Intestinal Failure (New York, N.Y.) · October 14, 2026 · Case report · cited 0 times
PMID 42909114 · DOI 10.1016/j.intf.2026.100399 · Human clinical research
- Safety and long-term effectiveness of teduglutide in children with intestinal failure due to short bowel syndrome: a multicenter, post-marketing cohort study.
Pediatric research · September 17, 2026 · Observational human study · cited 0 times · open access
PMID 42754721 · DOI 10.1038/s41390-026-05489-0 · Human clinical research
- Effectiveness, safety, and quality of life outcomes of teduglutide treatment in adult patients with short bowel syndrome-associated intestinal failure: A systematic literature review of real-world studies.
Intestinal Failure (New York, N.Y.) · September 15, 2026 · Review · cited 0 times · open access
PMID 42774842 · DOI 10.1016/j.intf.2026.100387 · Reviews and meta-analyses
- Comment on "real-world experience of teduglutide for the treatment of short bowel syndrome-associated intestinal failure".
Clinical nutrition ESPEN · August 31, 2026 · Editorial, letter or other · cited 0 times
PMID 42674361 · DOI 10.1016/j.clnesp.2026.105083 · Commentary and other
- Efficacy and safety of teduglutide in children with short bowel syndrome: a narrative review.
Pediatric surgery international · August 20, 2026 · Review · cited 0 times
PMID 42622692 · DOI 10.1007/s00383-026-06474-8 · Reviews and meta-analyses
- Successful treatment with teduglutide in short bowel syndrome with intestinal failure secondary to small-bowel volvulus: a case report and literature review.
International journal of surgery case reports · August 17, 2026 · Case report · cited 0 times · open access
PMID 42699525 · DOI 10.1097/rc9.0000000000000863 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: ALX-0600; Gattex; Revestive; Teduglutide
((TITLE_ABS:"ALX-0600" OR CHEM:"ALX-0600" OR TITLE_ABS:"ALX0600" OR CHEM:"ALX0600") OR (TITLE_ABS:"Gattex" OR CHEM:"Gattex") OR (TITLE_ABS:"Revestive" OR CHEM:"Revestive") OR (TITLE_ABS:"Teduglutide" OR CHEM:"Teduglutide")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Teduglutide research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/teduglutide