TB-500 (Thymosin Beta-4 fragment) research: publications and trials

Status in the library: Research only. Groups: Tissue-repair peptides.

• Fewer than three randomized controlled trials are indexed.
• Fewer than 25 publications are indexed, so year-to-year changes are not meaningful.

Recruiting: 1
Phase 1 / Phase 2: 1

No human trial, systematic review or meta-analysis of TB-500 (Thymosin Beta-4 fragment) is indexed.

1. Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry.

   Journal of separation science · December 15, 2015 · In vitro study · cited 48 times

   PMID 26578461 · DOI 10.1002/jssc.201501060 · In vitro studies

2. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry.

   Journal of chromatography. A · September 23, 2012 · Animal study · cited 45 times

   PMID 23084823 · DOI 10.1016/j.chroma.2012.09.043 · Animal studies

3. Doping control analysis of seven bioactive peptides in horse plasma by liquid chromatography-mass spectrometry.

   Analytical and bioanalytical chemistry · January 15, 2013 · Animal study · cited 40 times

   PMID 23318763 · DOI 10.1007/s00216-012-6697-9 · Animal studies

4. In vitro models for metabolic studies of small peptide hormones in sport drug testing.

   Journal of peptide science : an official publication of the European Peptide Society · December 3, 2014 · In vitro study · cited 39 times · open access

   PMID 25469748 · DOI 10.1002/psc.2710 · In vitro studies

5. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential.

   Drug testing and analysis · September 7, 2012 · In vitro study · cited 39 times · open access

   PMID 22962027 · DOI 10.1002/dta.1402 · In vitro studies

1. Investigational Peptides in Orthopaedic Practice: Evidence, Safety, and Patient Counseling for BPC-157, Thymosin Beta-4, and TB-500.

   The Journal of the American Academy of Orthopaedic Surgeons · October 27, 2026 · Review · cited 0 times

   PMID 42937313 · DOI 10.5435/jaaos-d-26-00049 · Reviews and meta-analyses

2. Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases.

   Frontiers in oral health · September 30, 2026 · Case report · cited 0 times · open access

   PMID 42876687 · DOI 10.3389/froh.2026.1907109 · Human clinical research

3. Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.

   Current pain and headache reports · August 24, 2026 · Review · cited 0 times

   PMID 42635865 · DOI 10.1007/s11916-026-01542-z · Reviews and meta-analyses

4. Peptide Supplements and Their Therapeutic Applications in Sports Medicine.

   The American journal of sports medicine · August 11, 2026 · Review · cited 1 times · open access

   PMID 42578445 · DOI 10.1177/03635465261464420 · Reviews and meta-analyses

5. Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.

   The Analyst · July 27, 2026 · In vitro study · cited 0 times

   PMID 42328738 · DOI 10.1039/d6an00455e · In vitro studies

6. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.

   Joint diseases and related surgery · July 23, 2026 · Animal study · cited 0 times · open access

   PMID 42542926 · DOI 10.52312/jdrs.2026.2951 · Animal studies

7. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.

   Sports medicine (Auckland, N.Z.) · April 12, 2026 · Review · cited 8 times · open access

   PMID 41966639 · DOI 10.1007/s40279-026-02437-0 · Reviews and meta-analyses

8. Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.

   Frontiers in aging · April 7, 2026 · Review · cited 4 times · open access

   PMID 42021992 · DOI 10.3389/fragi.2026.1790247 · Reviews and meta-analyses

9. Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.

   The American journal of sports medicine · January 1, 2026 · Review · cited 12 times

   PMID 41476424 · DOI 10.1177/03635465251357593 · Reviews and meta-analyses

10. Thymosin β4-derived peptides alleviate neuroinflammation and neurite atrophy in both in vitro models and in vivo 5 × FAD mice: A potential therapy for memory improvement in Alzheimer's disease.

    International immunopharmacology · December 23, 2025 · Animal study · cited 1 times

    PMID 41443105 · DOI 10.1016/j.intimp.2025.116097 · Animal studies

Browse all 21 publications in the dashboard

PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: Ac-LKKTETQ; TB-500

((TITLE_ABS:"Ac-LKKTETQ" OR CHEM:"Ac-LKKTETQ") OR (TITLE_ABS:"TB-500" OR CHEM:"TB-500" OR TITLE_ABS:"TB500" OR CHEM:"TB500")) AND SRC:MED