Peptide Library

Research statistics

Secretin research: publications and trials

What has been published on Secretin: PubMed publications, the kind of evidence they report and registered clinical trials. These are counts of research, not a judgment of whether Secretin works or is safe. For what it is and what the studies found, see the Secretin profile.
Automated weekly refresh · data through November 1, 2026

At a glance

Publications, all years

6,854

Since 1906

Publications in 2026 so far

16

Through November 1, 2026

Human clinical research

25.6%

1,372 of 5,352 classified

Registered clinical trials

37

ClinicalTrials.gov

Randomized controlled trials

87

Publications reporting an RCT in people

Systematic reviews and meta-analyses

10

Preclinical studies

60.7%

2,856 animal · 340 in vitro · 52 computational

Records that only mention it

2,244

Not counted above

Status in the library: FDA-approved. 1,502 publications are not yet classified by study type.

What to keep in mind

  • Some completed trials have neither posted results nor a linked results publication.
  • The body makes this molecule itself, so much of its literature is physiology rather than research on it as a compound.

Publications by year

Secretin publications by year and evidence

1906, Other and not yet classified: 2 of 21907, Other and not yet classified: 1 of 11908, Other and not yet classified: 1 of 11909, Other and not yet classified: 1 of 11912, Preclinical (animal, in vitro, computational): 1 of 31912, Other and not yet classified: 2 of 31921, Other and not yet classified: 1 of 11925, Other and not yet classified: 1 of 11926, Other and not yet classified: 2 of 21928, Other and not yet classified: 2 of 21929, Other and not yet classified: 1 of 11932, Other and not yet classified: 1 of 11937, Other and not yet classified: 1 of 11939, Other and not yet classified: 2 of 21941, Other and not yet classified: 1 of 11945, Other and not yet classified: 1 of 11946, Other and not yet classified: 1 of 11947, Human clinical research: 1 of 61947, Other and not yet classified: 5 of 61948, Preclinical (animal, in vitro, computational): 2 of 131948, Other and not yet classified: 11 of 131949, Other and not yet classified: 8 of 81950, Preclinical (animal, in vitro, computational): 1 of 141950, Other and not yet classified: 13 of 141951, Preclinical (animal, in vitro, computational): 1 of 101951, Other and not yet classified: 9 of 101952, Preclinical (animal, in vitro, computational): 1 of 101952, Reviews and meta-analyses: 1 of 101952, Other and not yet classified: 8 of 101953, Preclinical (animal, in vitro, computational): 2 of 91953, Other and not yet classified: 7 of 91954, Other and not yet classified: 4 of 41955, Other and not yet classified: 6 of 61956, Other and not yet classified: 5 of 51957, Preclinical (animal, in vitro, computational): 3 of 111957, Other and not yet classified: 8 of 111958, Preclinical (animal, in vitro, computational): 1 of 51958, Other and not yet classified: 4 of 51959, Preclinical (animal, in vitro, computational): 2 of 131959, Other and not yet classified: 11 of 131960, Human clinical research: 2 of 101960, Other and not yet classified: 8 of 101961, Preclinical (animal, in vitro, computational): 1 of 131961, Other and not yet classified: 12 of 131962, Preclinical (animal, in vitro, computational): 7 of 181962, Other and not yet classified: 11 of 181963, Human clinical research: 1 of 381963, Preclinical (animal, in vitro, computational): 4 of 381963, Reviews and meta-analyses: 1 of 381963, Other and not yet classified: 32 of 381964, Preclinical (animal, in vitro, computational): 16 of 591964, Reviews and meta-analyses: 3 of 591964, Other and not yet classified: 40 of 591965, Human clinical research: 1 of 501965, Preclinical (animal, in vitro, computational): 24 of 501965, Reviews and meta-analyses: 2 of 501965, Other and not yet classified: 23 of 501966, Human clinical research: 3 of 721966, Preclinical (animal, in vitro, computational): 33 of 721966, Reviews and meta-analyses: 1 of 721966, Other and not yet classified: 35 of 721967, Human clinical research: 3 of 1051967, Preclinical (animal, in vitro, computational): 34 of 1051967, Reviews and meta-analyses: 7 of 1051967, Other and not yet classified: 61 of 1051968, Human clinical research: 3 of 1241968, Preclinical (animal, in vitro, computational): 43 of 1241968, Reviews and meta-analyses: 5 of 1241968, Other and not yet classified: 73 of 1241969, Human clinical research: 4 of 1771969, Preclinical (animal, in vitro, computational): 78 of 1771969, Reviews and meta-analyses: 9 of 1771969, Other and not yet classified: 86 of 1771970, Human clinical research: 10 of 1771970, Preclinical (animal, in vitro, computational): 61 of 1771970, Reviews and meta-analyses: 20 of 1771970, Other and not yet classified: 86 of 1771971, Human clinical research: 4 of 1801971, Preclinical (animal, in vitro, computational): 79 of 1801971, Reviews and meta-analyses: 16 of 1801971, Other and not yet classified: 81 of 1801972, Human clinical research: 8 of 2071972, Preclinical (animal, in vitro, computational): 84 of 2071972, Reviews and meta-analyses: 22 of 2071972, Other and not yet classified: 93 of 2071973, Human clinical research: 13 of 2081973, Preclinical (animal, in vitro, computational): 84 of 2081973, Reviews and meta-analyses: 22 of 2081973, Other and not yet classified: 89 of 2081974, Human clinical research: 11 of 2391974, Preclinical (animal, in vitro, computational): 95 of 2391974, Reviews and meta-analyses: 20 of 2391974, Other and not yet classified: 113 of 2391975, Human clinical research: 57 of 2411975, Preclinical (animal, in vitro, computational): 94 of 2411975, Reviews and meta-analyses: 17 of 2411975, Other and not yet classified: 73 of 2411976, Human clinical research: 62 of 2631976, Preclinical (animal, in vitro, computational): 98 of 2631976, Reviews and meta-analyses: 38 of 2631976, Other and not yet classified: 65 of 2631977, Human clinical research: 50 of 2341977, Preclinical (animal, in vitro, computational): 105 of 2341977, Reviews and meta-analyses: 22 of 2341977, Other and not yet classified: 57 of 2341978, Human clinical research: 64 of 2511978, Preclinical (animal, in vitro, computational): 101 of 2511978, Reviews and meta-analyses: 22 of 2511978, Other and not yet classified: 64 of 2511979, Human clinical research: 48 of 2171979, Preclinical (animal, in vitro, computational): 106 of 2171979, Reviews and meta-analyses: 25 of 2171979, Other and not yet classified: 38 of 2171980, Human clinical research: 61 of 2241980, Preclinical (animal, in vitro, computational): 92 of 2241980, Reviews and meta-analyses: 27 of 2241980, Other and not yet classified: 44 of 2241981, Human clinical research: 46 of 1921981, Preclinical (animal, in vitro, computational): 91 of 1921981, Reviews and meta-analyses: 13 of 1921981, Other and not yet classified: 42 of 1921982, Human clinical research: 53 of 1861982, Preclinical (animal, in vitro, computational): 89 of 1861982, Reviews and meta-analyses: 14 of 1861982, Other and not yet classified: 30 of 1861983, Human clinical research: 51 of 1901983, Preclinical (animal, in vitro, computational): 102 of 1901983, Reviews and meta-analyses: 14 of 1901983, Other and not yet classified: 23 of 1901984, Human clinical research: 54 of 1931984, Preclinical (animal, in vitro, computational): 91 of 1931984, Reviews and meta-analyses: 21 of 1931984, Other and not yet classified: 27 of 1931985, Human clinical research: 57 of 1911985, Preclinical (animal, in vitro, computational): 90 of 1911985, Reviews and meta-analyses: 10 of 1911985, Other and not yet classified: 34 of 1911986, Human clinical research: 49 of 2031986, Preclinical (animal, in vitro, computational): 129 of 2031986, Reviews and meta-analyses: 9 of 2031986, Other and not yet classified: 16 of 2031987, Human clinical research: 33 of 1271987, Preclinical (animal, in vitro, computational): 80 of 1271987, Reviews and meta-analyses: 5 of 1271987, Other and not yet classified: 9 of 1271988, Human clinical research: 47 of 1291988, Preclinical (animal, in vitro, computational): 70 of 1291988, Reviews and meta-analyses: 5 of 1291988, Other and not yet classified: 7 of 1291989, Human clinical research: 42 of 1301989, Preclinical (animal, in vitro, computational): 80 of 1301989, Reviews and meta-analyses: 4 of 1301989, Other and not yet classified: 4 of 1301990, Human clinical research: 34 of 1311990, Preclinical (animal, in vitro, computational): 81 of 1311990, Reviews and meta-analyses: 5 of 1311990, Other and not yet classified: 11 of 1311991, Human clinical research: 29 of 1111991, Preclinical (animal, in vitro, computational): 72 of 1111991, Reviews and meta-analyses: 4 of 1111991, Other and not yet classified: 6 of 1111992, Human clinical research: 18 of 931992, Preclinical (animal, in vitro, computational): 61 of 931992, Reviews and meta-analyses: 3 of 931992, Other and not yet classified: 11 of 931993, Human clinical research: 16 of 1011993, Preclinical (animal, in vitro, computational): 77 of 1011993, Reviews and meta-analyses: 4 of 1011993, Other and not yet classified: 4 of 1011994, Human clinical research: 15 of 841994, Preclinical (animal, in vitro, computational): 62 of 841994, Reviews and meta-analyses: 4 of 841994, Other and not yet classified: 3 of 841995, Human clinical research: 14 of 831995, Preclinical (animal, in vitro, computational): 62 of 831995, Reviews and meta-analyses: 4 of 831995, Other and not yet classified: 3 of 831996, Human clinical research: 12 of 781996, Preclinical (animal, in vitro, computational): 55 of 781996, Reviews and meta-analyses: 7 of 781996, Other and not yet classified: 4 of 781997, Human clinical research: 17 of 751997, Preclinical (animal, in vitro, computational): 48 of 751997, Reviews and meta-analyses: 7 of 751997, Other and not yet classified: 3 of 751998, Human clinical research: 23 of 851998, Preclinical (animal, in vitro, computational): 55 of 851998, Reviews and meta-analyses: 3 of 851998, Other and not yet classified: 4 of 851999, Human clinical research: 22 of 781999, Preclinical (animal, in vitro, computational): 45 of 781999, Reviews and meta-analyses: 5 of 781999, Other and not yet classified: 6 of 782000, Human clinical research: 24 of 962000, Preclinical (animal, in vitro, computational): 50 of 962000, Reviews and meta-analyses: 9 of 962000, Other and not yet classified: 13 of 962001, Human clinical research: 21 of 722001, Preclinical (animal, in vitro, computational): 38 of 722001, Reviews and meta-analyses: 7 of 722001, Other and not yet classified: 6 of 722002, Human clinical research: 32 of 972002, Preclinical (animal, in vitro, computational): 39 of 972002, Reviews and meta-analyses: 14 of 972002, Other and not yet classified: 12 of 972003, Human clinical research: 19 of 602003, Preclinical (animal, in vitro, computational): 32 of 602003, Reviews and meta-analyses: 8 of 602003, Other and not yet classified: 1 of 602004, Human clinical research: 19 of 602004, Preclinical (animal, in vitro, computational): 29 of 602004, Reviews and meta-analyses: 7 of 602004, Other and not yet classified: 5 of 602005, Human clinical research: 15 of 592005, Preclinical (animal, in vitro, computational): 30 of 592005, Reviews and meta-analyses: 10 of 592005, Other and not yet classified: 4 of 592006, Human clinical research: 15 of 652006, Preclinical (animal, in vitro, computational): 27 of 652006, Reviews and meta-analyses: 16 of 652006, Other and not yet classified: 7 of 652007, Human clinical research: 16 of 442007, Preclinical (animal, in vitro, computational): 20 of 442007, Reviews and meta-analyses: 8 of 442008, Human clinical research: 22 of 542008, Preclinical (animal, in vitro, computational): 23 of 542008, Reviews and meta-analyses: 7 of 542008, Other and not yet classified: 2 of 542009, Human clinical research: 16 of 502009, Preclinical (animal, in vitro, computational): 22 of 502009, Reviews and meta-analyses: 8 of 502009, Other and not yet classified: 4 of 502010, Human clinical research: 11 of 452010, Preclinical (animal, in vitro, computational): 23 of 452010, Reviews and meta-analyses: 8 of 452010, Other and not yet classified: 3 of 452011, Human clinical research: 7 of 362011, Preclinical (animal, in vitro, computational): 21 of 362011, Reviews and meta-analyses: 5 of 362011, Other and not yet classified: 3 of 362012, Human clinical research: 12 of 512012, Preclinical (animal, in vitro, computational): 31 of 512012, Reviews and meta-analyses: 7 of 512012, Other and not yet classified: 1 of 512013, Human clinical research: 13 of 442013, Preclinical (animal, in vitro, computational): 20 of 442013, Reviews and meta-analyses: 8 of 442013, Other and not yet classified: 3 of 442014, Human clinical research: 11 of 352014, Preclinical (animal, in vitro, computational): 12 of 352014, Reviews and meta-analyses: 7 of 352014, Other and not yet classified: 5 of 352015, Human clinical research: 6 of 292015, Preclinical (animal, in vitro, computational): 18 of 292015, Reviews and meta-analyses: 2 of 292015, Other and not yet classified: 3 of 292016, Human clinical research: 11 of 332016, Preclinical (animal, in vitro, computational): 12 of 332016, Reviews and meta-analyses: 6 of 332016, Other and not yet classified: 4 of 332017, Human clinical research: 12 of 352017, Preclinical (animal, in vitro, computational): 18 of 352017, Reviews and meta-analyses: 3 of 352017, Other and not yet classified: 2 of 352018, Human clinical research: 8 of 282018, Preclinical (animal, in vitro, computational): 11 of 282018, Reviews and meta-analyses: 3 of 282018, Other and not yet classified: 6 of 282019, Human clinical research: 1 of 162019, Preclinical (animal, in vitro, computational): 10 of 162019, Reviews and meta-analyses: 3 of 162019, Other and not yet classified: 2 of 162020, Human clinical research: 12 of 322020, Preclinical (animal, in vitro, computational): 11 of 322020, Reviews and meta-analyses: 8 of 322020, Other and not yet classified: 1 of 322021, Human clinical research: 6 of 192021, Preclinical (animal, in vitro, computational): 7 of 192021, Reviews and meta-analyses: 4 of 192021, Other and not yet classified: 2 of 192022, Human clinical research: 8 of 262022, Preclinical (animal, in vitro, computational): 14 of 262022, Reviews and meta-analyses: 3 of 262022, Other and not yet classified: 1 of 262023, Human clinical research: 4 of 182023, Preclinical (animal, in vitro, computational): 10 of 182023, Reviews and meta-analyses: 3 of 182023, Other and not yet classified: 1 of 182024, Human clinical research: 4 of 152024, Preclinical (animal, in vitro, computational): 10 of 152024, Reviews and meta-analyses: 1 of 152025, Human clinical research: 4 of 162025, Preclinical (animal, in vitro, computational): 9 of 162025, Reviews and meta-analyses: 2 of 162025, Other and not yet classified: 1 of 162026 (to date), Human clinical research: 5 of 162026 (to date), Preclinical (animal, in vitro, computational): 8 of 162026 (to date), Reviews and meta-analyses: 2 of 162026 (to date), Other and not yet classified: 1 of 16Human clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classified0100200300190619511971199120112026*
Counted PubMed publications by year of first publication. * 2026 runs to November 1, 2026. A larger bar is more publications, not stronger evidence.
Show the data
YearHuman clinical researchPreclinical (animal, in vitro, computational)Reviews and meta-analysesOther and not yet classifiedTotal
190600022
190700011
190800011
190900011
191201023
192100011
192500011
192600022
192800022
192900011
193200011
193700011
193900022
194100011
194500011
194600011
194710056
19480201113
194900088
19500101314
1951010910
1952011810
195302079
195400044
195500066
195600055
1957030811
195801045
19590201113
1960200810
19610101213
19620701118
19631413238
196401634059
196512422350
196633313572
1967334761105
1968343573124
1969478986177
197010612086177
19714791681180
19728842293207
197313842289208
1974119520113239
197557941773241
197662983865263
1977501052257234
1978641012264251
1979481062538217
198061922744224
198146911342192
198253891430186
1983511021423190
198454912127193
198557901034191
198649129916203
1987338059127
1988477057129
1989428044130
19903481511131
1991297246111
1992186131193
1993167744101
199415624384
199514624383
199612557478
199717487375
199823553485
199922455678
2000245091396
200121387672
20023239141297
200319328160
200419297560
2005153010459
2006152716765
200716208044
200822237254
200916228450
201011238345
20117215336
201212317151
201313208344
201411127535
20156182329
201611126433
201712183235
20188113628
20191103216
202012118132
2021674219
20228143126
20234103118
20244101015
2025492116
2026 (to date)582116

Study types

Animal study2,856
Not yet classified1,502
Other clinical trial606
Review580
Observational human study532
In vitro study340
Case report147
Editorial, letter or other132
Randomized controlled trial87
Computational study52
Meta-analysis6
Correction or retraction notice6
Guideline or consensus4
Systematic review4

Research areas

From MeSH major topics. A paper can be in several areas.

Gastrointestinal3,725
Endocrinology1,221
Metabolic health629
Oncology511
Neurological and mental health321
Cardiovascular172
Antimicrobial and infectious disease117
Immune system107
Musculoskeletal72
Obesity and weight management53
Reproductive and sexual health53
Longevity and aging27

Registered clinical trials

5 of 16 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.

Completed: 19 · Terminated: 6 · Withdrawn: 4 · Unknown status: 3 · Enrolling by invitation: 2 · Active, not recruiting: 1 · Not yet recruiting: 1 · Recruiting: 1
Early phase 1: 1 · Phase not applicable: 11 · Phase 1: 4 · Phase 1 / Phase 2: 5 · Phase 2: 3 · Phase 2 / Phase 3: 2 · Phase 3: 8 · Phase 4: 3

TrialStatusPhaseStartedResults
A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy SubjectsNCT07285863 · 24 enrolledActive, not recruitingPhase 42026-03—
Secretin in Ex-situ Liver PerfusionNCT07651748 · 20 enrolledEnrolling by invitationPhase 1, Phase 22025-04—
The Influence of Secretin Stimulated Pancreatic Secretion on ctDNA Expression in Patients With Pancreatic Ductal Adenocarcinoma: The Role of Biomarkers in Determining the Prognosis of Pancreatic Ductal AdenocarcinomaNCT06807112 · 39 enrolledNot yet recruitingPhase not applicable2025-02—
Aspiration of Duodenopancreatic Juice After Secretin Stimulation vs Endoscopic Aspiration for Molecular Analysis of Intraductal Papillary Mucinous Intraductal Neoplasia.NCT05914077 · 140 enrolledUnknown statusPhase 32023-09—
Imaging Biomarkers of Pancreatic Function and DiseaseNCT05659147 · 195 enrolledEnrolling by invitationPhase 42023-01—
Recurrent Abdominal Pain and Exocrine Pancreatic InsufficiencyNCT04231279 · 27 enrolledTerminatedPhase 32022-01—
The Role of Secretin on the Energy HomeostasisNCT04613700 · 25 enrolledCompletedPhase not applicable2020-03—
Effect of Secretin in Functional Dyspepsia and Healthy SubjectsNCT03617861 · 20 enrolledCompletedPhase 1, Phase 22018-11Posted
Secretin for Acute PancreatitisNCT03686618 · 40 enrolledUnknown statusPhase 22018-10—
Optical and Biochemical Biomarkers in Early Pancreatic CancerNCT03404661 · 346 enrolledCompletedPhase not applicable2018-01—
Intraductal Secretin Stimulation Test: What Is the Proper Collection Time?NCT03263481 · 8 enrolledCompletedPhase not applicable2017-09—
Evidence Based Management of Acute Biliary PancreatitisNCT04615702 · 30 enrolledCompletedPhase not applicable2017-05—
MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in PediatricsNCT02869893 · 57 enrolledCompletedPhase not applicable2016-08Posted
Secretin Activates Human Brown Fat and Induces Satiation.NCT03290846 · 23 enrolledCompletedPhase 2, Phase 32016-08—
Secretin Infusion to Prevent Pancreatic Leaks Following Pancreatic ResectionNCT02160808 · 170 enrolledCompletedPhase 2, Phase 32014-05Posted
The Cancer of the Pancreas Screening-5 CAPS5)StudyNCT02000089 · 9,000 enrolledRecruitingPhase 32014-01—
Comparison of Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) to Endoscopic Pancreatic Function Test (ePFT) in Diagnosing Pancreatic Exocrine InsufficiencyNCT01094600WithdrawnPhase not applicable2012-06—
Pancreatic Perfusion Using Secretin and MRINCT02458118 · 15 enrolledUnknown statusPhase 1, Phase 22012-06—
Secretin-Assisted Computed Tomography Scan and Magnetic Resonance Imaging in Improving Pancreatic Tumor ConspicuityNCT01371240WithdrawnEarly phase 12011-06—
Secretin Infusion for Pain Due to Chronic PancreatitisNCT01265875 · 12 enrolledCompletedPhase 1, Phase 22010-12Posted
Non-invasive MRI to Quantify the Effect of Secretin on Pancreatic Blood Flow and Perfusion in Healthy VolunteersNCT01452217 · 12 enrolledCompletedPhase 12010-09—
Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer DetectionNCT01094626WithdrawnPhase not applicable2010-04—
A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy VolunteersNCT01134848 · 10 enrolledCompletedPhase 42009-01—
Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the PancreasNCT00660335 · 258 enrolledCompletedPhase 32008-03—
Secretin Enhanced Multidetector CT Pancreatography for Evaluation of Known or Suspected Chronic PancreatitisNCT00620919TerminatedPhase 12008-02—
Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric PopulationNCT00621283TerminatedPhase 12008-02—
Secretin Enhanced MRCP for Evaluation of the Known or Suspected Intraductal Papillary Mucinous Neoplasms of the PancreasNCT00621556 · 2 enrolledTerminatedPhase 12008-02—
A Study of Synthetic Human Secretin (ChiRhoStim®) Administered Intravenously to Stimulate Exocrine Pancreas Fluid Secretion for Collection Via Endoscope and Laboratory Analysis of DNA MarkersNCT01087801 · 64 enrolledCompletedPhase 32007-10Posted
Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic Function Following SurgeryNCT01094535WithdrawnPhase not applicable2007-09—
Cancer of the Pancreas Screening Study (CAPS 3)NCT00438906 · 200 enrolledCompletedPhase not applicable2006-12—
Secretin (ChiRhoStim) Pancreas Perfusion for Pancreatic AdenocarcinomaNCT00587132 · 4 enrolledTerminatedPhase 1, Phase 22006-11Posted
Secretin-Stimulated Magnetic Resonance Cholangiopancreatography (S-MRCP) in Pancreatic PatientsNCT01094561 · 23 enrolledCompletedPhase not applicable2006-07Posted
Effects of RG1068 (Secretin) on Information Processing in SchizophreniaNCT00235274 · 30 enrolledCompletedPhase 22005-11—
Safety Study of the Drug RG1068 in Patients With Obsessive Compulsive DisorderNCT00216294 · 12 enrolledCompletedPhase 22005-02—
Synthetic Human Secretin in Children With Autism and Gastrointestinal DysfunctionNCT00036231TerminatedPhase 32002-04—
Synthetic Human Secretin in Children With AutismNCT00036244CompletedPhase 32002-04—
Secretin for the Treatment of AutismNCT00065962 · 85 enrolledCompletedPhase 31999-06—

Human trials and evidence reviews

Meta-analyses, systematic reviews and trials in people, newest first.

  1. The Accuracies of Diagnosing Pancreas Divisum by Magnetic Resonance Cholangiopancreatography and Endoscopic Ultrasound: A Systematic Review and Meta-analysis.

    Scientific reports · October 13, 2016 · Meta-analysis · cited 36 times · open access

    PMID 27734952 · DOI 10.1038/srep35389 · Reviews and meta-analyses

  2. Magnetic resonance cholangiopancreatography in the diagnosis of pancreas divisum: a systematic review and meta-analysis.

    Pancreas · August 1, 2014 · Meta-analysis · cited 44 times

    PMID 24743381 · DOI 10.1097/mpa.0000000000000143 · Reviews and meta-analyses

  3. Intravenous secretin for autism spectrum disorders (ASD).

    The Cochrane database of systematic reviews · April 18, 2012 · Meta-analysis · cited 128 times · open access

    PMID 22513913 · DOI 10.1002/14651858.cd003495.pub3 · Reviews and meta-analyses

  4. Serum gastrin in Zollinger-Ellison syndrome: II. Prospective study of gastrin provocative testing in 293 patients from the National Institutes of Health and comparison with 537 cases from the literature. evaluation of diagnostic criteria, proposal of new criteria, and correlations with clinical and tumoral features.

    Medicine · November 1, 2006 · Meta-analysis · cited 188 times · open access

    PMID 17108779 · DOI 10.1097/md.0b013e31802b518c · Reviews and meta-analyses

  5. Intravenous secretin for autism spectrum disorder.

    The Cochrane database of systematic reviews · July 20, 2005 · Meta-analysis · cited 62 times · open access

    PMID 16034901 · DOI 10.1002/14651858.cd003495.pub2 · Reviews and meta-analyses

  6. Secretin as a treatment for autism: a review of the evidence.

    Journal of autism and developmental disorders · October 1, 2004 · Meta-analysis · cited 56 times

    PMID 15628608 · DOI 10.1007/s10803-004-2549-6 · Reviews and meta-analyses

  7. Various Modalities Accurate in Diagnosing a Disrupted or Disconnected Pancreatic Duct in Acute Pancreatitis: A Systematic Review.

    Digestive diseases and sciences · June 27, 2020 · Systematic review · cited 44 times · open access

    PMID 32594462 · DOI 10.1007/s10620-020-06413-0 · Reviews and meta-analyses

  8. Secretin-Stimulated Magnetic Resonance Imaging Assessment of the Benign Pancreatic Disorders: Systematic Review and Proposal for a Standardized Protocol.

    Pancreas · September 1, 2016 · Systematic review · cited 27 times

    PMID 27171509 · DOI 10.1097/mpa.0000000000000606 · Reviews and meta-analyses

  9. A systematic review of secretin for children with autism spectrum disorders.

    Pediatrics · April 4, 2011 · Systematic review · cited 64 times · open access

    PMID 21464196 · DOI 10.1542/peds.2011-0428 · Reviews and meta-analyses

  10. Autism.

    BMJ clinical evidence · January 7, 2010 · Systematic review · cited 4 times · open access

    PMID 21729335 · Reviews and meta-analyses

Most cited

By OpenAlex citation count. Citations measure attention, not quality or correctness.

  1. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

    Proceedings of the National Academy of Sciences of the United States of America · January 1, 1998 · Animal study · cited 3,880 times · open access

    PMID 9419374 · DOI 10.1073/pnas.95.1.322 · Animal studies

  2. Polypeptide with broad biological activity: isolation from small intestine.

    Science (New York, N.Y.) · September 1, 1970 · Animal study · cited 1,596 times

    PMID 5450698 · DOI 10.1126/science.169.3951.1217 · Animal studies

  3. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

    Development (Cambridge, England) · March 1, 1996 · Animal study · cited 1,514 times

    PMID 8631275 · DOI 10.1242/dev.122.3.983 · Animal studies

  4. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.

    Genes & development · September 1, 1997 · Animal study · cited 1,022 times · open access

    PMID 9308961 · DOI 10.1101/gad.11.18.2323 · Animal studies

  5. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

    Endocrinology · December 1, 1993 · Animal study · cited 534 times

    PMID 8243312 · DOI 10.1210/endo.133.6.8243312 · Animal studies

Latest publications

  1. Structural and functional insights into rhodopsin-like and secretin-like GPCR-arrestin interactions and regulation.

    The FEBS journal · October 27, 2026 · Review · cited 0 times

    PMID 42936877 · DOI 10.1111/febs.70772 · Reviews and meta-analyses

  2. Beyond Digestion: Secretin as a Key Regulator of Systemic pH.

    Annual review of physiology · October 16, 2026 · Review · cited 0 times

    PMID 42887002 · DOI 10.1146/annurev-physiol-040425-040843 · Reviews and meta-analyses

  3. Intestinal FXR agonism synergizes with leptin to improve obesity by reducing appetite via secretin.

    EMBO reports · October 5, 2026 · Animal study · cited 0 times · open access

    PMID 42834123 · DOI 10.1038/s44319-026-00938-7 · Animal studies

  4. A milk interleukin-10/gut secretin axis promotes brown adipose tissue thermogenesis in breastfeeding newborns.

    Cell reports · September 11, 2026 · Animal study · cited 0 times · open access

    PMID 42731027 · DOI 10.1016/j.celrep.2026.117928 · Animal studies

  5. Effects of Glucagon-Like Peptide 1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide on Fluid Secretion in Guinea-Pig Pancreatic Duct Cells.

    Pancreas · September 1, 2026 · Animal study · cited 0 times

    PMID 42081276 · DOI 10.1097/mpa.0000000000002661 · Animal studies

  6. Impaired Renal Base Excretion in Secretin Receptor Knock-Out Mice During Prolonged Base-Loading.

    Acta physiologica (Oxford, England) · September 1, 2026 · Animal study · cited 0 times · open access

    PMID 42535685 · DOI 10.1111/apha.70286 · Animal studies

  7. Pancreatic Fluid Enzymes as a Functional Chronic Pancreatitis Biomarker: A Pilot Endoscopic Study.

    Pancreas · August 27, 2026 · Other clinical trial · cited 0 times

    PMID 42657664 · DOI 10.1097/mpa.0000000000002703 · Human clinical research

  8. Recurrent acute pancreatitis caused by a duodenal diverticulum: The diagnostic value of secretin-enhanced magnetic resonance cholangiopancreatography.

    Journal of pediatric gastroenterology and nutrition · August 24, 2026 · Case report · cited 0 times · open access

    PMID 42638397 · DOI 10.1002/jpn3.70553 · Human clinical research

  9. Identification and Characterization of a Phenyl(trifluoro-methyl)-pyrimidine Positive Allosteric Modulator of the Secretin Receptor.

    Membranes · July 21, 2026 · In vitro study · cited 0 times · open access

    PMID 42506214 · DOI 10.3390/membranes16070249 · In vitro studies

  10. Secretin-interacting plug proteins prevent antibiotic influx during type IV pilus assembly in Pseudomonas aeruginosa.

    Nature communications · May 29, 2026 · In vitro study · cited 0 times · open access

    PMID 42215499 · DOI 10.1038/s41467-026-73864-w · In vitro studies

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How this is counted

PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology

Search terms: ChiRhoStim; Human secretin; SecreFlo; SecreFlow; Secretin; Secretina; Secretine; Secretinum; Secretolin

((TITLE_ABS:"ChiRhoStim" OR CHEM:"ChiRhoStim") OR (TITLE_ABS:"Human secretin" OR CHEM:"Human secretin") OR (TITLE_ABS:"SecreFlo" OR CHEM:"SecreFlo") OR (TITLE_ABS:"SecreFlow" OR CHEM:"SecreFlow") OR (TITLE_ABS:"Secretin" OR CHEM:"Secretin") OR (TITLE_ABS:"Secretina" OR CHEM:"Secretina") OR (TITLE_ABS:"Secretine" OR CHEM:"Secretine") OR (TITLE_ABS:"Secretinum" OR CHEM:"Secretinum") OR (TITLE_ABS:"Secretolin" OR CHEM:"Secretolin")) AND SRC:MED

Cite this page

Peptide Library. (2026, November 2). Secretin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/secretin