Peptide LibraryResearch statistics
Plecanatide research: publications and trials
At a glance
Publications, all years
90
Since 2013
Publications in 2026 so far
6
Through November 1, 2026
Human clinical research
31.0%
27 of 87 classified
Registered clinical trials
15
ClinicalTrials.gov
Randomized controlled trials
13
Publications reporting an RCT in people
Systematic reviews and meta-analyses
10
Preclinical studies
9.2%
3 animal · 2 in vitro · 3 computational
Records that only mention it
28
Not counted above
Status in the library: FDA-approved. 3 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Plecanatide publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 2013 | 1 | 0 | 0 | 1 | 2 |
| 2014 | 0 | 0 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 2 | 1 | 4 |
| 2016 | 0 | 0 | 1 | 1 | 2 |
| 2017 | 2 | 2 | 2 | 7 | 13 |
| 2018 | 3 | 1 | 9 | 3 | 16 |
| 2019 | 1 | 0 | 6 | 0 | 7 |
| 2020 | 2 | 0 | 2 | 1 | 5 |
| 2021 | 0 | 2 | 3 | 0 | 5 |
| 2022 | 1 | 0 | 1 | 1 | 3 |
| 2023 | 3 | 0 | 0 | 2 | 5 |
| 2024 | 3 | 0 | 0 | 2 | 5 |
| 2025 | 10 | 1 | 4 | 0 | 15 |
| 2026 (to date) | 1 | 1 | 4 | 0 | 6 |
Study types
| Review | 25 |
|---|---|
| Editorial, letter or other | 14 |
| Randomized controlled trial | 13 |
| Observational human study | 12 |
| Meta-analysis | 7 |
| Animal study | 3 |
| Computational study | 3 |
| Guideline or consensus | 3 |
| Systematic review | 3 |
| Not yet classified | 3 |
| Other clinical trial | 2 |
| In vitro study | 2 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Gastrointestinal | 75 |
|---|---|
| Immune system | 3 |
| Musculoskeletal | 2 |
| Neurological and mental health | 2 |
| Oncology | 2 |
| Cardiovascular | 1 |
| Dermatology | 1 |
Registered clinical trials
2 of 13 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 14 · Active, not recruiting: 1
Phase not applicable: 1 · Phase 1: 1 · Phase 2: 5 · Phase 2 / Phase 3: 1 · Phase 3: 7
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Gut relief revisited: plecanatide in chronic idiopathic constipation and irritable bowel syndrome with constipation - a systematic review and meta-analysis with GRADE assessment.
BMC gastroenterology · October 26, 2026 · Meta-analysis · cited 0 times
PMID 42934540 · DOI 10.1186/s12876-026-05112-w · Reviews and meta-analyses
- Efficacy and tolerability of plecanatide for irritable bowel syndrome with constipation and chronic idiopathic constipation: a systematic review and meta-analysis.
European journal of gastroenterology & hepatology · January 13, 2026 · Meta-analysis · cited 0 times
PMID 41604554 · DOI 10.1097/meg.0000000000003115 · Reviews and meta-analyses
- Efficacy and safety of pharmacological therapies for functional constipation in children: a systematic review and meta-analysis.
The Lancet. Child & adolescent health · October 13, 2025 · Meta-analysis · cited 6 times · open access
PMID 41101321 · DOI 10.1016/s2352-4642(25)00219-6 · Reviews and meta-analyses
- The Safety of Pharmacotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.
The American journal of gastroenterology · June 5, 2025 · Meta-analysis · cited 8 times · open access
PMID 40471839 · DOI 10.14309/ajg.0000000000003572 · Reviews and meta-analyses
- Comparative Efficacy of Drugs for the Treatment of Chronic Constipation: Quantitative Information for Medication Guidelines.
Journal of clinical gastroenterology · November 1, 2020 · Meta-analysis · cited 7 times
PMID 31904680 · DOI 10.1097/mcg.0000000000001303 · Reviews and meta-analyses
- EFFICACY AND SAFETY OF INTESTINAL SECRETAGOGUES FOR CHRONIC CONSTIPATION: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Arquivos de gastroenterologia · August 6, 2018 · Meta-analysis · cited 23 times · open access
PMID 30088533 · DOI 10.1590/s0004-2803.201800000-41 · Reviews and meta-analyses
- Efficacy and Tolerability of Guanylate Cyclase-C Agonists for Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis.
The American journal of gastroenterology · January 30, 2018 · Meta-analysis · cited 119 times · open access
PMID 29380823 · DOI 10.1038/ajg.2017.495 · Reviews and meta-analyses
- Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.
Frontiers in pharmacology · April 10, 2026 · Systematic review · cited 0 times · open access
PMID 42038325 · DOI 10.3389/fphar.2026.1761301 · Reviews and meta-analyses
- Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis.
The lancet. Gastroenterology & hepatology · August 29, 2019 · Systematic review · cited 138 times
PMID 31474542 · DOI 10.1016/s2468-1253(19)30246-8 · Reviews and meta-analyses
- Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis.
Gastroenterology · August 23, 2018 · Systematic review · cited 164 times
PMID 30144426 · DOI 10.1053/j.gastro.2018.08.021 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.
Gastroenterology · June 1, 2023 · Guideline or consensus · cited 180 times · open access
PMID 37211380 · DOI 10.1053/j.gastro.2023.03.214 · Commentary and other
- Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis.
Gastroenterology · August 23, 2018 · Systematic review · cited 164 times
PMID 30144426 · DOI 10.1053/j.gastro.2018.08.021 · Reviews and meta-analyses
- AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation.
Gastroenterology · July 1, 2022 · Guideline or consensus · cited 160 times · open access
PMID 35738724 · DOI 10.1053/j.gastro.2022.04.016 · Commentary and other
- Efficacy, safety, and tolerability of plecanatide in patients with irritable bowel syndrome with constipation: results of two phase 3 randomized clinical trials.
The American journal of gastroenterology · March 15, 2018 · Randomized controlled trial · cited 145 times
PMID 29545635 · DOI 10.1038/s41395-018-0026-7 · Human clinical research
- A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation.
The American journal of gastroenterology · February 7, 2017 · Randomized controlled trial · cited 143 times · open access
PMID 28169285 · DOI 10.1038/ajg.2016.611 · Human clinical research
Latest publications
- Gut relief revisited: plecanatide in chronic idiopathic constipation and irritable bowel syndrome with constipation - a systematic review and meta-analysis with GRADE assessment.
BMC gastroenterology · October 26, 2026 · Meta-analysis · cited 0 times
PMID 42934540 · DOI 10.1186/s12876-026-05112-w · Reviews and meta-analyses
- Patients' Real-World Experiences With Pharmacologic Therapies for Irritable Bowel Syndrome With Constipation: A Mixed-Methods Analysis and Classification of Social Media and E-Forum Posts.
Neurogastroenterology and motility · September 1, 2026 · Observational human study · cited 0 times · open access
PMID 42694017 · DOI 10.1111/nmo.70432 · Human clinical research
- Irritable Bowel Syndrome with Constipation: Diagnosis and Multisymptom Management Beyond Abdominal Pain and Bowel Movement Frequency: A Review.
Advances in therapy · June 12, 2026 · Review · cited 0 times · open access
PMID 42283961 · DOI 10.1007/s12325-026-03645-w · Reviews and meta-analyses
- A targeted partial reduction cyanylation strategy coupled with HRMS for accurate disulfide bridge mapping in disulfide rich cyclic peptides.
Journal of chromatography. A · June 1, 2026 · In vitro study · cited 0 times
PMID 42242129 · DOI 10.1016/j.chroma.2026.467160 · In vitro studies
- Efficacy and safety of Guanylyl cyclase C agonists (linaclotide and plecanatide) in patients with irritable bowel syndrome with constipation: a systematic review and meta-analysis of randomized controlled trials.
Frontiers in pharmacology · April 10, 2026 · Systematic review · cited 0 times · open access
PMID 42038325 · DOI 10.3389/fphar.2026.1761301 · Reviews and meta-analyses
- Efficacy and tolerability of plecanatide for irritable bowel syndrome with constipation and chronic idiopathic constipation: a systematic review and meta-analysis.
European journal of gastroenterology & hepatology · January 13, 2026 · Meta-analysis · cited 0 times
PMID 41604554 · DOI 10.1097/meg.0000000000003115 · Reviews and meta-analyses
- The Effectiveness of Plecanatide for Treating Constipation and Bloating in Patients Aged 18 to 40 Years With Irritable Bowel Syndrome: Utilization of a New Composite Trisymptom Endpoint.
Journal of gastroenterology and hepatology · November 10, 2025 · Randomized controlled trial · cited 3 times · open access
PMID 41214272 · DOI 10.1111/jgh.70119 · Human clinical research
- Plecanatide Is Efficacious in Women Aged 18 to 40 Years With IBS-C and Bloating: A Pooled Analysis of Two Phase 3, Randomized, Placebo-Controlled Trials.
Gastroenterology & hepatology · November 1, 2025 · Observational human study · cited 0 times
PMID 41625190 · Human clinical research
- Improvement in Health-Related Quality of Life in Adults With IBS-C Not Achieving Bowel Movement Frequency Criterion: Analysis of Two Phase 3 Plecanatide Trials.
Gastroenterology & hepatology · November 1, 2025 · Observational human study · cited 0 times · open access
PMID 41625188 · Human clinical research
- Real-World Safety Analysis of the Constipation-Predominant IBS Treatment Options Linaclotide, Lubiprostone, Plecanatide, and Tenapanor.
Gastroenterology & hepatology · November 1, 2025 · Observational human study · cited 0 times · open access
PMID 41625191 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Guanilib; Plecanatide; SP-304; Trulance
((TITLE_ABS:"Guanilib" OR CHEM:"Guanilib") OR (TITLE_ABS:"Plecanatide" OR CHEM:"Plecanatide") OR (TITLE_ABS:"SP-304" OR CHEM:"SP-304" OR TITLE_ABS:"SP304" OR CHEM:"SP304") OR (TITLE_ABS:"Trulance" OR CHEM:"Trulance")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Plecanatide research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/plecanatide