Peptide LibraryResearch statistics
Nafarelin research: publications and trials
At a glance
Publications, all years
352
Since 1981
Publications in 2026 so far
1
Through November 1, 2026
Human clinical research
68.0%
219 of 322 classified
Registered clinical trials
10
ClinicalTrials.gov
Randomized controlled trials
65
Publications reporting an RCT in people
Systematic reviews and meta-analyses
2
Preclinical studies
16.1%
34 animal · 12 in vitro · 6 computational
Records that only mention it
20
Not counted above
Status in the library: FDA-approved. 30 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Nafarelin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1981 | 0 | 2 | 0 | 0 | 2 |
| 1983 | 0 | 1 | 0 | 0 | 1 |
| 1984 | 3 | 5 | 0 | 1 | 9 |
| 1985 | 7 | 6 | 1 | 0 | 14 |
| 1986 | 7 | 2 | 1 | 1 | 11 |
| 1987 | 4 | 2 | 0 | 2 | 8 |
| 1988 | 5 | 2 | 2 | 5 | 14 |
| 1989 | 12 | 1 | 2 | 8 | 23 |
| 1990 | 16 | 1 | 5 | 3 | 25 |
| 1991 | 8 | 2 | 3 | 4 | 17 |
| 1992 | 11 | 1 | 4 | 3 | 19 |
| 1993 | 10 | 2 | 2 | 1 | 15 |
| 1994 | 18 | 2 | 3 | 6 | 29 |
| 1995 | 14 | 2 | 0 | 1 | 17 |
| 1996 | 12 | 2 | 0 | 0 | 14 |
| 1997 | 9 | 0 | 0 | 0 | 9 |
| 1998 | 9 | 0 | 2 | 0 | 11 |
| 1999 | 9 | 0 | 1 | 0 | 10 |
| 2000 | 15 | 0 | 4 | 1 | 20 |
| 2001 | 10 | 0 | 2 | 0 | 12 |
| 2002 | 6 | 0 | 0 | 0 | 6 |
| 2003 | 5 | 4 | 1 | 0 | 10 |
| 2004 | 4 | 1 | 0 | 0 | 5 |
| 2005 | 3 | 0 | 0 | 0 | 3 |
| 2006 | 2 | 1 | 3 | 1 | 7 |
| 2007 | 0 | 0 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 1 | 0 | 3 |
| 2009 | 4 | 0 | 1 | 1 | 6 |
| 2010 | 2 | 1 | 0 | 0 | 3 |
| 2011 | 2 | 1 | 0 | 0 | 3 |
| 2012 | 0 | 3 | 0 | 0 | 3 |
| 2013 | 2 | 1 | 0 | 1 | 4 |
| 2014 | 1 | 0 | 0 | 0 | 1 |
| 2015 | 1 | 2 | 1 | 0 | 4 |
| 2016 | 1 | 0 | 0 | 0 | 1 |
| 2017 | 1 | 1 | 0 | 1 | 3 |
| 2020 | 1 | 2 | 1 | 0 | 4 |
| 2023 | 0 | 1 | 0 | 0 | 1 |
| 2024 | 1 | 1 | 0 | 0 | 2 |
| 2025 | 1 | 0 | 0 | 0 | 1 |
| 2026 (to date) | 1 | 0 | 0 | 0 | 1 |
Study types
| Other clinical trial | 79 |
|---|---|
| Randomized controlled trial | 65 |
| Observational human study | 49 |
| Review | 39 |
| Animal study | 34 |
| Not yet classified | 30 |
| Case report | 26 |
| In vitro study | 12 |
| Editorial, letter or other | 10 |
| Computational study | 6 |
| Meta-analysis | 1 |
| Systematic review | 1 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Reproductive and sexual health | 260 |
|---|---|
| Endocrinology | 113 |
| Oncology | 59 |
| Neurological and mental health | 27 |
| Musculoskeletal | 25 |
| Metabolic health | 13 |
| Dermatology | 11 |
| Antimicrobial and infectious disease | 5 |
| Gastrointestinal | 5 |
| Immune system | 5 |
| Tissue repair | 2 |
| Cardiovascular | 1 |
Registered clinical trials
1 of 3 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 3 · Recruiting: 3 · Unknown status: 2 · Not yet recruiting: 1 · Withdrawn: 1
Early phase 1: 1 · Phase not applicable: 3 · Phase 1 / Phase 2: 1 · Phase 2: 1 · Phase 3: 1 · Phase 4: 3
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Efficacy of nafarelin in assisted reproductive technology: a meta-analysis.
Human reproduction update · January 1, 2001 · Meta-analysis · cited 14 times
PMID 11212082 · DOI 10.1093/humupd/7.1.92 · Reviews and meta-analyses
- Teriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis: systematic review.
Sao Paulo medical journal = Revista paulista de medicina · September 1, 2008 · Systematic review · cited 24 times · open access
PMID 19099162 · DOI 10.1590/s1516-31802008000500007 · Reviews and meta-analyses
- Long gonadotropin-releasing hormone agonist versus short agonist versus antagonist regimens in poor responders undergoing in vitro fertilization: a randomized controlled trial.
Fertility and sterility · November 1, 2013 · Randomized controlled trial · cited 110 times · open access
PMID 24188873 · DOI 10.1016/j.fertnstert.2013.09.035 · Human clinical research
- A randomised controlled trial of 300 versus 225 IU recombinant FSH for ovarian stimulation in predicted normal responders by antral follicle count.
BJOG : an international journal of obstetrics and gynaecology · March 29, 2010 · Randomized controlled trial · cited 47 times
PMID 20353458 · DOI 10.1111/j.1471-0528.2010.02545.x · Human clinical research
- Recrudescence of spermatogenesis in the dog following downregulation using a slow release GnRH agonist implant.
Reproduction in domestic animals = Zuchthygiene · July 1, 2009 · Randomized controlled trial · cited 48 times
PMID 19754591 · DOI 10.1111/j.1439-0531.2009.01378.x · Human clinical research
- Prospective randomised trial comparing gonadotrophin-releasing hormone analogues with triple tourniquets at open myomectomy.
BJOG : an international journal of obstetrics and gynaecology · February 4, 2009 · Randomized controlled trial · cited 35 times
PMID 19191779 · DOI 10.1111/j.1471-0528.2008.02022.x · Human clinical research
- Luteal phase characteristics following GnRH antagonist or agonist treatment - a comparative study.
Reproductive biomedicine online · January 1, 2006 · Randomized controlled trial · cited 32 times
PMID 16454930 · DOI 10.1016/s1472-6483(10)60976-5 · Human clinical research
- A comparative randomized trial to assess the impact of oral contraceptive pretreatment on follicular growth and hormone profiles in GnRH antagonist-treated patients.
Human reproduction (Oxford, England) · October 27, 2005 · Randomized controlled trial · cited 90 times
PMID 16253978 · DOI 10.1093/humrep/dei302 · Human clinical research
- A randomized, parallel, comparative study of the efficacy and safety of nafarelin versus danazol in the treatment of endometriosis in Taiwan.
Journal of the Chinese Medical Association : JCMA · July 1, 2005 · Randomized controlled trial · cited 22 times
PMID 16038370 · DOI 10.1016/s1726-4901(09)70166-2 · Human clinical research
- Impact of six months of GnRH agonist therapy for endometriosis. Is there an age-related effect on bone mineral density?
The Journal of reproductive medicine · July 1, 2002 · Randomized controlled trial · cited 13 times
PMID 12170527 · Human clinical research
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Consensus statement on the use of gonadotropin-releasing hormone analogs in children.
Pediatrics · March 30, 2009 · Review · cited 820 times · open access
PMID 19332438 · DOI 10.1542/peds.2008-1783 · Reviews and meta-analyses
- Administration of nasal nafarelin as compared with oral danazol for endometriosis. A multicenter double-blind comparative clinical trial.
The New England journal of medicine · February 1, 1988 · Randomized controlled trial · cited 361 times
PMID 2963213 · DOI 10.1056/nejm198802253180805 · Human clinical research
- The effect of nafarelin acetate, a luteinizing-hormone-releasing hormone agonist, on benign prostatic hyperplasia.
The New England journal of medicine · September 1, 1987 · Other clinical trial · cited 338 times
PMID 2441256 · DOI 10.1056/nejm198709033171004 · Human clinical research
- Detection of functional ovarian hyperandrogenism in women with androgen excess.
The New England journal of medicine · July 1, 1992 · Observational human study · cited 327 times · open access
PMID 1319000 · DOI 10.1056/nejm199207163270304 · Human clinical research
- Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome.
The New England journal of medicine · March 1, 1989 · Other clinical trial · cited 311 times
PMID 2521688 · DOI 10.1056/nejm198903023200904 · Human clinical research
Latest publications
- Is there a difference in ovarian hyperstimulation syndrome rates in freeze-all treatment cycles in high-risk patients treated with different GnRH agonist triggers?
Human fertility (Cambridge, England) · October 5, 2026 · Observational human study · cited 0 times · open access
PMID 42831293 · DOI 10.1080/14647273.2026.2733078 · Human clinical research
- Trends in endometriosis interventions: an interrupted time series analysis following the Australian National Action Plan for Endometriosis (NAPE) 2018.
Australian health review : a publication of the Australian Hospital Association · August 1, 2025 · Observational human study · cited 0 times · open access
PMID 40623680 · DOI 10.1071/ah25047 · Human clinical research
- A study on the efficacy and safety of long-term adjusted low-dose gonadotropin-releasing hormone agonist therapy for uterine fibroids and adenomyosis.
The journal of obstetrics and gynaecology research · October 27, 2024 · Observational human study · cited 1 times
PMID 39462178 · DOI 10.1111/jog.16128 · Human clinical research
- Mechanistic Model for Drug Release from PLGA-Based Biodegradable Implants for <i>In Vitro</i> Release Testing: Development and Validation.
ACS applied bio materials · October 18, 2024 · Computational study · cited 18 times · open access
PMID 39424342 · DOI 10.1021/acsabm.4c01054 · Computational studies
- Anti-Dengue: A Machine Learning-Assisted Prediction of Small Molecule Antivirals against Dengue Virus and Implications in Drug Repurposing.
Viruses · December 27, 2023 · Computational study · cited 30 times · open access
PMID 38257744 · DOI 10.3390/v16010045 · Computational studies
- Gonadotropin-Releasing Hormone (GnRH) Agonist Implants for Male Dog Fertility Suppression: A Review of Mode of Action, Efficacy, Safety, and Uses.
Frontiers in veterinary science · August 14, 2020 · Review · cited 31 times · open access
PMID 32923467 · DOI 10.3389/fvets.2020.00483 · Reviews and meta-analyses
- GnRHa for trigger and luteal phase support in natural cycle frozen embryo transfer - A proof of concept study.
Reproductive biology · July 30, 2020 · Other clinical trial · cited 8 times
PMID 32741721 · DOI 10.1016/j.repbio.2020.07.009 · Human clinical research
- Detection of bioactive peptides including gonadotrophin-releasing factors (GnRHs) in horse urine using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC/HRMS).
Drug testing and analysis · July 17, 2020 · Animal study · cited 22 times
PMID 32558326 · DOI 10.1002/dta.2880 · Animal studies
- In silico analysis and identification of promising hits against 2019 novel coronavirus 3C-like main protease enzyme.
Journal of biomolecular structure & dynamics · July 1, 2020 · Computational study · cited 37 times
PMID 32608329 · DOI 10.1080/07391102.2020.1787228 · Computational studies
- Caspase-3 gene expression in human luteinized granulosa cells is inversely correlated with the number of oocytes retrieved after controlled ovarian stimulation.
Human fertility (Cambridge, England) · July 25, 2017 · Observational human study · cited 10 times
PMID 28738699 · DOI 10.1080/14647273.2017.1356474 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Nafarelin; Nafarelina; Nafareline; Nafarelinum; RS-94991; Synarel
((TITLE_ABS:"Nafarelin" OR CHEM:"Nafarelin") OR (TITLE_ABS:"Nafarelina" OR CHEM:"Nafarelina") OR (TITLE_ABS:"Nafareline" OR CHEM:"Nafareline") OR (TITLE_ABS:"Nafarelinum" OR CHEM:"Nafarelinum") OR (TITLE_ABS:"RS-94991" OR CHEM:"RS-94991" OR TITLE_ABS:"RS94991" OR CHEM:"RS94991") OR (TITLE_ABS:"Synarel" OR CHEM:"Synarel")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Nafarelin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/nafarelin