Peptide LibraryResearch statistics
Histrelin research: publications and trials
At a glance
Publications, all years
124
Since 1981
Publications in 2026 so far
2
Through November 1, 2026
Human clinical research
58.2%
71 of 122 classified
Registered clinical trials
8
ClinicalTrials.gov
Randomized controlled trials
1
Publications reporting an RCT in people
Systematic reviews and meta-analyses
0
Preclinical studies
25.4%
24 animal · 5 in vitro · 2 computational
Records that only mention it
21
Not counted above
Status in the library: FDA-approved. 2 publications are not yet classified by study type.
What to keep in mind
- Fewer than three randomized controlled trials are indexed.
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Histrelin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1981 | 0 | 1 | 0 | 0 | 1 |
| 1982 | 0 | 1 | 0 | 0 | 1 |
| 1983 | 0 | 1 | 0 | 0 | 1 |
| 1984 | 2 | 5 | 0 | 0 | 7 |
| 1985 | 0 | 3 | 0 | 0 | 3 |
| 1986 | 2 | 2 | 0 | 0 | 4 |
| 1987 | 3 | 2 | 0 | 0 | 5 |
| 1988 | 1 | 0 | 0 | 0 | 1 |
| 1989 | 2 | 2 | 0 | 0 | 4 |
| 1990 | 2 | 0 | 1 | 0 | 3 |
| 1991 | 1 | 2 | 0 | 0 | 3 |
| 1992 | 2 | 0 | 0 | 1 | 3 |
| 1993 | 0 | 0 | 2 | 0 | 2 |
| 1994 | 0 | 0 | 1 | 1 | 2 |
| 1995 | 1 | 0 | 0 | 0 | 1 |
| 1997 | 1 | 0 | 0 | 0 | 1 |
| 1999 | 2 | 2 | 0 | 1 | 5 |
| 2000 | 1 | 0 | 0 | 0 | 1 |
| 2001 | 2 | 0 | 1 | 0 | 3 |
| 2004 | 1 | 0 | 0 | 0 | 1 |
| 2005 | 3 | 0 | 2 | 0 | 5 |
| 2006 | 1 | 0 | 0 | 0 | 1 |
| 2007 | 1 | 0 | 0 | 0 | 1 |
| 2008 | 1 | 0 | 0 | 0 | 1 |
| 2009 | 2 | 0 | 4 | 0 | 6 |
| 2010 | 4 | 2 | 1 | 0 | 7 |
| 2011 | 1 | 0 | 1 | 0 | 2 |
| 2012 | 2 | 0 | 0 | 0 | 2 |
| 2013 | 3 | 0 | 1 | 0 | 4 |
| 2014 | 3 | 0 | 0 | 0 | 3 |
| 2015 | 2 | 2 | 1 | 0 | 5 |
| 2016 | 1 | 0 | 0 | 0 | 1 |
| 2018 | 4 | 0 | 1 | 0 | 5 |
| 2019 | 5 | 1 | 0 | 0 | 6 |
| 2020 | 0 | 1 | 0 | 0 | 1 |
| 2021 | 6 | 1 | 0 | 0 | 7 |
| 2022 | 1 | 0 | 1 | 0 | 2 |
| 2023 | 4 | 0 | 1 | 0 | 5 |
| 2024 | 1 | 0 | 0 | 1 | 2 |
| 2025 | 2 | 2 | 0 | 0 | 4 |
| 2026 (to date) | 1 | 1 | 0 | 0 | 2 |
Study types
| Observational human study | 31 |
|---|---|
| Other clinical trial | 26 |
| Animal study | 24 |
| Review | 18 |
| Case report | 13 |
| In vitro study | 5 |
| Computational study | 2 |
| Editorial, letter or other | 2 |
| Not yet classified | 2 |
| Randomized controlled trial | 1 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Endocrinology | 81 |
|---|---|
| Reproductive and sexual health | 66 |
| Oncology | 34 |
| Neurological and mental health | 19 |
| Gastrointestinal | 4 |
| Metabolic health | 3 |
| Antimicrobial and infectious disease | 2 |
| Cardiovascular | 1 |
| Cognitive health | 1 |
| Immune system | 1 |
| Longevity and aging | 1 |
| Obesity and weight management | 1 |
Registered clinical trials
2 of 5 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 5 · Terminated: 2 · Active, not recruiting: 1
Phase not applicable: 3 · Phase 2: 1 · Phase 2 / Phase 3: 1 · Phase 3: 3
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Successful treatment of severe premenstrual syndrome by combined use of gonadotropin-releasing hormone agonist and estrogen/progestin.
The Journal of clinical endocrinology and metabolism · February 1, 1991 · Randomized controlled trial · cited 157 times
PMID 1846868 · DOI 10.1210/jcem-72-2-252 · Human clinical research
- Long-Term Continuous Suppression With Once-Yearly Histrelin Subcutaneous Implants for the Treatment of Central Precocious Puberty: A Final Report of a Phase 3 Multicenter Trial.
The Journal of clinical endocrinology and metabolism · March 24, 2015 · Other clinical trial · cited 62 times · open access
PMID 25803268 · DOI 10.1210/jc.2014-3031 · Human clinical research
- Random unstimulated pediatric luteinizing hormone levels are not reliable in the assessment of pubertal suppression during histrelin implant therapy.
International journal of pediatric endocrinology · December 2, 2013 · Other clinical trial · cited 35 times · open access
PMID 24295437 · DOI 10.1186/1687-9856-2013-20 · Human clinical research
- A single histrelin implant is effective for 2 years for treatment of central precocious puberty.
The Journal of pediatrics · July 1, 2013 · Other clinical trial · cited 63 times · open access
PMID 23809043 · DOI 10.1016/j.jpeds.2013.05.033 · Human clinical research
- Long-term efficacy and tolerability of once-yearly histrelin acetate subcutaneous implant in patients with advanced prostate cancer.
BJU international · August 18, 2011 · Other clinical trial · cited 30 times
PMID 21851539 · DOI 10.1111/j.1464-410x.2011.10370.x · Human clinical research
- Free alpha-subunit is the most sensitive marker of gonadotropin recovery after treatment of central precocious puberty with the histrelin implant.
The Journal of clinical endocrinology and metabolism · March 25, 2010 · Other clinical trial · cited 15 times · open access
PMID 20339028 · DOI 10.1210/jc.2009-2078 · Human clinical research
- Results of a second year of therapy with the 12-month histrelin implant for the treatment of central precocious puberty.
International journal of pediatric endocrinology · February 26, 2009 · Other clinical trial · cited 28 times · open access
PMID 19956699 · DOI 10.1155/2009/812517 · Human clinical research
- Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial.
The Journal of clinical endocrinology and metabolism · February 27, 2007 · Other clinical trial · cited 121 times
PMID 17327379 · DOI 10.1210/jc.2006-2479 · Human clinical research
- Efficacy and safety of histrelin subdermal implant in patients with advanced prostate cancer.
The Journal of urology · April 1, 2006 · Other clinical trial · cited 56 times
PMID 16515997 · DOI 10.1016/s0022-5347(05)00649-x · Human clinical research
- The histrelin implant: a novel treatment for central precocious puberty.
Pediatrics · December 1, 2005 · Other clinical trial · cited 67 times
PMID 16322137 · DOI 10.1542/peds.2005-0538 · Human clinical research
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Treatment and outcomes of precocious puberty: an update.
The Journal of clinical endocrinology and metabolism · March 20, 2013 · Review · cited 258 times
PMID 23515450 · DOI 10.1210/jc.2013-1024 · Reviews and meta-analyses
- Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.
Molecular pharmaceutics · February 10, 2015 · In vitro study · cited 246 times · open access
PMID 25612507 · DOI 10.1021/mp500809f · In vitro studies
- Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience.
The Journal of clinical endocrinology and metabolism · October 1, 2001 · Other clinical trial · cited 215 times · open access
PMID 11600530 · DOI 10.1210/jcem.86.10.7915 · Human clinical research
- Successful treatment of severe premenstrual syndrome by combined use of gonadotropin-releasing hormone agonist and estrogen/progestin.
The Journal of clinical endocrinology and metabolism · February 1, 1991 · Randomized controlled trial · cited 157 times
PMID 1846868 · DOI 10.1210/jcem-72-2-252 · Human clinical research
- Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty.
The Journal of clinical endocrinology and metabolism · January 1, 1999 · Observational human study · cited 139 times · open access
PMID 9920060 · DOI 10.1210/jcem.84.1.5409 · Human clinical research
Latest publications
- Low-dose histrelin for ovulation induction in mares: a partially randomized crossover pilot study.
Veterinary research communications · October 20, 2026 · Animal study · cited 0 times · open access
PMID 42897392 · DOI 10.1007/s11259-026-11583-9 · Animal studies
- Case Report: Sustained pubertal suppression for 68 months with a single histrelin acetate implant in central precocious puberty.
Frontiers in endocrinology · October 9, 2026 · Case report · cited 0 times · open access
PMID 42920604 · DOI 10.3389/fendo.2026.1951374 · Human clinical research
- Adverse event profile differences among long-acting gonadotropin-releasing hormone analogs: A real-world, pharmacovigilance study.
PloS one · July 11, 2025 · Computational study · cited 4 times · open access
PMID 40644420 · DOI 10.1371/journal.pone.0327842 · Computational studies
- FDA-approved drugs as potential covalent inhibitors of key SARS-CoV-2 proteins: an in silico approach.
Turkish journal of biology = Turk biyoloji dergisi · April 7, 2025 · Computational study · cited 0 times · open access
PMID 40678415 · DOI 10.55730/1300-0152.2741 · Computational studies
- Study of persistence and adherence to ADT in prostate cancer: relugolix, degarelix, and GnRH agonists in the US.
Future oncology (London, England) · April 6, 2025 · Observational human study · cited 5 times · open access
PMID 40189880 · DOI 10.1080/14796694.2025.2480050 · Human clinical research
- Prolonged Pubertal Suppression due to Retained Histrelin Implant in Three Children with Central Precocious Puberty.
Hormone research in paediatrics · February 27, 2025 · Case report · cited 3 times
PMID 40015262 · DOI 10.1159/000544181 · Human clinical research
- Risk of cardiovascular events following intermittent and continuous androgen deprivation therapy in patients with nonmetastatic prostate cancer.
Urologic oncology · July 12, 2024 · Observational human study · cited 4 times · open access
PMID 39003108 · DOI 10.1016/j.urolonc.2024.05.026 · Human clinical research
- Precocious Puberty and GnRH Analogs: Current Treatment Practices and Perspectives among US Pediatric Endocrinologists.
Hormone research in paediatrics · May 8, 2024 · Editorial, letter or other · cited 12 times · open access
PMID 38718766 · DOI 10.1159/000539011 · Commentary and other
- Trends in Histrelin Implantation at a Pediatric Tertiary Care Center.
The Journal of surgical research · June 21, 2023 · Observational human study · cited 3 times
PMID 37352739 · DOI 10.1016/j.jss.2023.05.019 · Human clinical research
- Extended Use of Histrelin Implant in Pediatric Patients.
Transgender health · June 1, 2023 · Observational human study · cited 13 times · open access
PMID 37342480 · DOI 10.1089/trgh.2021.0130 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Histrelin; Histrelina; Histreline; Histrelinum; RL-0903; Supprelin LA; Vantaas; Vantas
((TITLE_ABS:"Histrelin" OR CHEM:"Histrelin") OR (TITLE_ABS:"Histrelina" OR CHEM:"Histrelina") OR (TITLE_ABS:"Histreline" OR CHEM:"Histreline") OR (TITLE_ABS:"Histrelinum" OR CHEM:"Histrelinum") OR (TITLE_ABS:"RL-0903" OR CHEM:"RL-0903" OR TITLE_ABS:"RL0903" OR CHEM:"RL0903") OR (TITLE_ABS:"Supprelin LA" OR CHEM:"Supprelin LA") OR (TITLE_ABS:"Vantaas" OR CHEM:"Vantaas") OR (TITLE_ABS:"Vantas" OR CHEM:"Vantas")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Histrelin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/histrelin