Research statistics
Goserelin research: publications and trials
At a glance
Publications, all years
1,957
Since 1978
Publications in 2026 so far
24
Through November 1, 2026
Human clinical research
73.7%
1,385 of 1,878 classified
Registered clinical trials
301
ClinicalTrials.gov
Randomized controlled trials
429
Publications reporting an RCT in people
Systematic reviews and meta-analyses
34
Preclinical studies
9.8%
118 animal · 50 in vitro · 16 computational
Records that only mention it
241
Not counted above
Status in the library: FDA-approved. 79 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Goserelin publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1978 | 0 | 1 | 0 | 0 | 1 |
| 1979 | 0 | 1 | 0 | 0 | 1 |
| 1980 | 0 | 1 | 0 | 0 | 1 |
| 1981 | 0 | 2 | 0 | 0 | 2 |
| 1982 | 1 | 1 | 1 | 0 | 3 |
| 1983 | 5 | 3 | 0 | 1 | 9 |
| 1984 | 4 | 4 | 1 | 3 | 12 |
| 1985 | 4 | 4 | 1 | 2 | 11 |
| 1986 | 11 | 2 | 0 | 5 | 18 |
| 1987 | 15 | 5 | 1 | 10 | 31 |
| 1988 | 32 | 4 | 1 | 6 | 43 |
| 1989 | 32 | 10 | 5 | 14 | 61 |
| 1990 | 50 | 4 | 5 | 7 | 66 |
| 1991 | 40 | 4 | 4 | 12 | 60 |
| 1992 | 37 | 7 | 6 | 5 | 55 |
| 1993 | 52 | 1 | 4 | 4 | 61 |
| 1994 | 51 | 5 | 7 | 11 | 74 |
| 1995 | 40 | 4 | 2 | 3 | 49 |
| 1996 | 53 | 4 | 6 | 7 | 70 |
| 1997 | 39 | 3 | 2 | 4 | 48 |
| 1998 | 34 | 4 | 11 | 3 | 52 |
| 1999 | 41 | 2 | 3 | 6 | 52 |
| 2000 | 41 | 4 | 13 | 5 | 63 |
| 2001 | 44 | 4 | 7 | 3 | 58 |
| 2002 | 46 | 6 | 12 | 5 | 69 |
| 2003 | 35 | 3 | 13 | 7 | 58 |
| 2004 | 33 | 1 | 4 | 2 | 40 |
| 2005 | 44 | 3 | 10 | 4 | 61 |
| 2006 | 42 | 3 | 7 | 2 | 54 |
| 2007 | 39 | 5 | 9 | 2 | 55 |
| 2008 | 40 | 5 | 3 | 4 | 52 |
| 2009 | 44 | 2 | 5 | 9 | 60 |
| 2010 | 36 | 7 | 1 | 5 | 49 |
| 2011 | 36 | 2 | 4 | 5 | 47 |
| 2012 | 42 | 4 | 2 | 3 | 51 |
| 2013 | 41 | 6 | 3 | 10 | 60 |
| 2014 | 26 | 5 | 7 | 4 | 42 |
| 2015 | 31 | 8 | 5 | 8 | 52 |
| 2016 | 21 | 5 | 3 | 1 | 30 |
| 2017 | 18 | 4 | 1 | 1 | 24 |
| 2018 | 22 | 0 | 6 | 1 | 29 |
| 2019 | 24 | 4 | 2 | 0 | 30 |
| 2020 | 16 | 4 | 3 | 1 | 24 |
| 2021 | 21 | 3 | 3 | 0 | 27 |
| 2022 | 13 | 6 | 5 | 0 | 24 |
| 2023 | 17 | 4 | 1 | 0 | 22 |
| 2024 | 25 | 4 | 2 | 2 | 33 |
| 2025 | 29 | 6 | 3 | 1 | 39 |
| 2026 (to date) | 18 | 0 | 5 | 1 | 24 |
Study types
| Randomized controlled trial | 429 |
|---|---|
| Observational human study | 346 |
| Other clinical trial | 332 |
| Case report | 278 |
| Review | 165 |
| Animal study | 118 |
| Editorial, letter or other | 107 |
| Not yet classified | 79 |
| In vitro study | 50 |
| Meta-analysis | 25 |
| Computational study | 16 |
| Systematic review | 9 |
| Guideline or consensus | 2 |
| Correction or retraction notice | 1 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Oncology | 1,514 |
|---|---|
| Reproductive and sexual health | 1,349 |
| Dermatology | 382 |
| Endocrinology | 288 |
| Musculoskeletal | 115 |
| Neurological and mental health | 98 |
| Metabolic health | 53 |
| Gastrointestinal | 44 |
| Cardiovascular | 43 |
| Immune system | 31 |
| Tissue repair | 29 |
| Cognitive health | 15 |
Registered clinical trials
38 of 127 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 142 · Unknown status: 48 · Terminated: 34 · Active, not recruiting: 29 · Recruiting: 26 · Withdrawn: 12 · Not yet recruiting: 9 · Suspended: 1
Early phase 1: 1 · Phase not applicable: 27 · Phase 1: 23 · Phase 1 / Phase 2: 8 · Phase 2: 125 · Phase 2 / Phase 3: 7 · Phase 3: 91 · Phase 4: 19
The 50 most recently started of 301 trials.
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Meta-analysis of the effect of goserelin acetate implant on improving hormone levels in patients with endometriosis.
Pakistan journal of pharmaceutical sciences · April 1, 2026 · Meta-analysis · cited 0 times · open access
PMID 41761808 · DOI 10.36721/pjps.2026.39.4.reg.14460.1 · Reviews and meta-analyses
- Effect of Medical Therapies for Endometriosis on Bone Health: A Systematic Review and Meta-analysis.
Obstetrics and gynecology · March 19, 2026 · Meta-analysis · cited 2 times
PMID 41855532 · DOI 10.1097/aog.0000000000006241 · Reviews and meta-analyses
- Progestogens or progestogen-releasing intrauterine systems for uterine fibroids (other than preoperative medical therapy).
The Cochrane database of systematic reviews · November 23, 2020 · Meta-analysis · cited 33 times · open access
PMID 33226133 · DOI 10.1002/14651858.cd008994.pub3 · Reviews and meta-analyses
- Laparoscopic surgery for endometriosis.
The Cochrane database of systematic reviews · October 23, 2020 · Meta-analysis · cited 126 times
PMID 33095458 · DOI 10.1002/14651858.cd011031.pub3 · Reviews and meta-analyses
- Oral contraceptives for pain associated with endometriosis.
The Cochrane database of systematic reviews · May 22, 2018 · Meta-analysis · cited 199 times · open access
PMID 29786828 · DOI 10.1002/14651858.cd001019.pub3 · Reviews and meta-analyses
- Effects of ovarian ablation or suppression in premenopausal breast cancer: A meta-analysis of randomized controlled trials.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · December 5, 2016 · Meta-analysis · cited 23 times
PMID 28024943 · DOI 10.1016/j.ejso.2016.11.011 · Reviews and meta-analyses
- Degarelix for the treatment of advanced prostate cancer compared with GnRh-Agonists: a systematic review and meta-analysis.
Medical journal of the Islamic Republic of Iran · January 9, 2016 · Meta-analysis · cited 16 times · open access
PMID 27390687 · Reviews and meta-analyses
- Non-steroidal antiandrogen monotherapy compared with luteinising hormone-releasing hormone agonists or surgical castration monotherapy for advanced prostate cancer.
The Cochrane database of systematic reviews · June 30, 2014 · Meta-analysis · cited 69 times · open access
PMID 24979481 · DOI 10.1002/14651858.cd009266.pub2 · Reviews and meta-analyses
- Laparoscopic surgery for endometriosis.
The Cochrane database of systematic reviews · April 3, 2014 · Meta-analysis · cited 347 times · open access
PMID 24696265 · DOI 10.1002/14651858.cd011031.pub2 · Reviews and meta-analyses
- Non-surgical interventions for the management of chronic pelvic pain.
The Cochrane database of systematic reviews · March 5, 2014 · Meta-analysis · cited 153 times · open access
PMID 24595586 · DOI 10.1002/14651858.cd008797.pub2 · Reviews and meta-analyses
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial.
Lancet (London, England) · July 1, 2002 · Randomized controlled trial · cited 1,688 times
PMID 12126818 · DOI 10.1016/s0140-6736(02)09408-4 · Human clinical research
- Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin.
The New England journal of medicine · July 1, 1997 · Randomized controlled trial · cited 1,548 times · open access
PMID 9233866 · DOI 10.1056/nejm199707313370502 · Human clinical research
- Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer.
The New England journal of medicine · December 1, 1999 · Randomized controlled trial · cited 1,191 times
PMID 10588962 · DOI 10.1056/nejm199912093412401 · Human clinical research
- Endocrine therapy plus zoledronic acid in premenopausal breast cancer.
The New England journal of medicine · February 1, 2009 · Randomized controlled trial · cited 1,025 times · open access
PMID 19213681 · DOI 10.1056/nejmoa0806285 · Human clinical research
- External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study.
The Lancet. Oncology · October 7, 2010 · Randomized controlled trial · cited 948 times
PMID 20933466 · DOI 10.1016/s1470-2045(10)70223-0 · Human clinical research
Latest publications
- Comparison of cardiovascular events in patients with metastatic hormone sensitive prostate cancer treated with LHRH agonists to LHRH antagonists in the US: A retrospective cohort study.
Urologic oncology · October 18, 2026 · Observational human study · cited 0 times
PMID 42892580 · DOI 10.1016/j.urolonc.2026.09.012 · Human clinical research
- Extrauterine Adenomyoma of the Lung: A Rare Case Report.
International journal of women's health · September 5, 2026 · Case report · cited 0 times · open access
PMID 42719860 · DOI 10.2147/ijwh.s596873 · Human clinical research
- Fewer Injections and Lower Drug Costs With Long-Acting GnRH Depot Formulations: A Nationwide Analysis of 2.3 Million Patient-Years in Japan.
Cancer reports (Hoboken, N.J.) · September 1, 2026 · Observational human study · cited 0 times · open access
PMID 42728640 · DOI 10.1002/cnr2.70688 · Human clinical research
- Impact of leuprolide and goserelin on androgen suppression and adverse events in patients with prostate cancer.
The Canadian journal of urology · August 21, 2026 · Randomized controlled trial · cited 0 times · open access
PMID 42682049 · DOI 10.32604/cju.2026.069559 · Human clinical research
- Efficacy and safety of goserelin vs. leuprolide in premenopausal breast cancer patients receiving adjuvant endocrine therapy: A retrospective cohort study.
Medwave · August 19, 2026 · Observational human study · cited 0 times · open access
PMID 42617170 · DOI 10.5867/medwave.2026.07.3216 · Human clinical research
- Efficacy of goserelin combined with laparoscopic surgery for endometriosis and its effects on ovarian function and oxidative stress.
American journal of translational research · August 15, 2026 · Observational human study · cited 0 times · open access
PMID 42769464 · DOI 10.62347/dndw4937 · Human clinical research
- Darolutamide Alone and in Combination With Goserelin in Androgen Receptor-Positive Salivary Gland Carcinoma: Results From the Phase II DISCOVARY Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · August 3, 2026 · Other clinical trial · cited 0 times · open access
PMID 42546251 · DOI 10.1200/jco-25-03028 · Human clinical research
- Comparative effectiveness and integrated safety of goserelin sustained-release microspheres versus implants in prostate cancer: a patient-based real-world study and systematic review with meta-analysis.
Frontiers in oncology · June 17, 2026 · Observational human study · cited 0 times · open access
PMID 42388614 · DOI 10.3389/fonc.2026.1858453 · Human clinical research
- Thoracoabdominal endometriosis mimicking pulmonary tuberculosis in a TB-endemic setting: a case report.
Journal of medical case reports · June 14, 2026 · Case report · cited 0 times · open access
PMID 42289750 · DOI 10.1186/s13256-026-06150-4 · Human clinical research
- Pathological complete response to perioperative treatment with darolutamide plus ADT in locally advanced prostate cancer without PTEN or RB1 loss: a case report.
Frontiers in pharmacology · June 3, 2026 · Case report · cited 0 times · open access
PMID 42318353 · DOI 10.3389/fphar.2026.1829605 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Goserelin; Goserelina; Gosereline; Goserelinum; ICI-118630; Zoladex
((TITLE_ABS:"Goserelin" OR CHEM:"Goserelin") OR (TITLE_ABS:"Goserelina" OR CHEM:"Goserelina") OR (TITLE_ABS:"Gosereline" OR CHEM:"Gosereline") OR (TITLE_ABS:"Goserelinum" OR CHEM:"Goserelinum") OR (TITLE_ABS:"ICI-118630" OR CHEM:"ICI-118630" OR TITLE_ABS:"ICI118630" OR CHEM:"ICI118630") OR (TITLE_ABS:"Zoladex" OR CHEM:"Zoladex")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Goserelin research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/goserelin