Peptide LibraryResearch statistics
Ganirelix research: publications and trials
At a glance
Publications, all years
285
Since 1989
Publications in 2026 so far
2
Through November 1, 2026
Human clinical research
71.0%
201 of 283 classified
Registered clinical trials
67
ClinicalTrials.gov
Randomized controlled trials
76
Publications reporting an RCT in people
Systematic reviews and meta-analyses
8
Preclinical studies
9.5%
9 animal · 16 in vitro · 2 computational
Records that only mention it
30
Not counted above
Status in the library: FDA-approved. 2 publications are not yet classified by study type.
What to keep in mind
- Some completed trials have neither posted results nor a linked results publication.
Publications by year
Ganirelix publications by year and evidence
Show the data
| Year | Human clinical research | Preclinical (animal, in vitro, computational) | Reviews and meta-analyses | Other and not yet classified | Total |
|---|---|---|---|---|---|
| 1989 | 0 | 1 | 0 | 0 | 1 |
| 1990 | 0 | 1 | 0 | 0 | 1 |
| 1991 | 0 | 1 | 0 | 0 | 1 |
| 1992 | 1 | 1 | 0 | 0 | 2 |
| 1993 | 0 | 1 | 0 | 1 | 2 |
| 1995 | 1 | 0 | 0 | 0 | 1 |
| 1997 | 1 | 0 | 0 | 0 | 1 |
| 1998 | 3 | 0 | 2 | 0 | 5 |
| 1999 | 3 | 0 | 1 | 2 | 6 |
| 2000 | 3 | 1 | 1 | 3 | 8 |
| 2001 | 5 | 1 | 8 | 6 | 20 |
| 2002 | 6 | 0 | 7 | 0 | 13 |
| 2003 | 8 | 1 | 2 | 0 | 11 |
| 2004 | 13 | 0 | 4 | 1 | 18 |
| 2005 | 17 | 1 | 4 | 0 | 22 |
| 2006 | 7 | 0 | 5 | 0 | 12 |
| 2007 | 10 | 0 | 1 | 1 | 12 |
| 2008 | 12 | 1 | 1 | 0 | 14 |
| 2009 | 13 | 0 | 0 | 0 | 13 |
| 2010 | 10 | 4 | 0 | 0 | 14 |
| 2011 | 12 | 0 | 2 | 0 | 14 |
| 2012 | 17 | 0 | 0 | 0 | 17 |
| 2013 | 7 | 0 | 0 | 0 | 7 |
| 2014 | 5 | 0 | 0 | 0 | 5 |
| 2015 | 5 | 0 | 0 | 0 | 5 |
| 2016 | 11 | 1 | 0 | 0 | 12 |
| 2017 | 1 | 0 | 0 | 0 | 1 |
| 2019 | 6 | 1 | 0 | 0 | 7 |
| 2020 | 4 | 2 | 1 | 0 | 7 |
| 2021 | 7 | 2 | 0 | 0 | 9 |
| 2022 | 4 | 1 | 0 | 0 | 5 |
| 2023 | 2 | 4 | 2 | 0 | 8 |
| 2024 | 2 | 1 | 1 | 0 | 4 |
| 2025 | 4 | 1 | 0 | 0 | 5 |
| 2026 (to date) | 1 | 0 | 1 | 0 | 2 |
Study types
| Randomized controlled trial | 76 |
|---|---|
| Observational human study | 66 |
| Other clinical trial | 41 |
| Review | 35 |
| Case report | 18 |
| In vitro study | 16 |
| Editorial, letter or other | 12 |
| Animal study | 9 |
| Meta-analysis | 6 |
| Computational study | 2 |
| Systematic review | 2 |
| Not yet classified | 2 |
Research areas
From MeSH major topics. A paper can be in several areas.
| Reproductive and sexual health | 226 |
|---|---|
| Endocrinology | 126 |
| Oncology | 24 |
| Immune system | 8 |
| Longevity and aging | 7 |
| Neurological and mental health | 6 |
| Cardiovascular | 5 |
| Dermatology | 3 |
| Metabolic health | 2 |
| Obesity and weight management | 2 |
| Cognitive health | 1 |
Registered clinical trials
22 of 43 trials completed at least a year before the cutoff have neither posted results nor a linked results publication. A registration is not a result.
Completed: 44 · Unknown status: 12 · Terminated: 4 · Active, not recruiting: 2 · Recruiting: 2 · Withdrawn: 2 · Not yet recruiting: 1
Early phase 1: 5 · Phase not applicable: 22 · Phase 1: 1 · Phase 1 / Phase 2: 1 · Phase 2: 3 · Phase 3: 12 · Phase 4: 23
The 50 most recently started of 67 trials.
Human trials and evidence reviews
Meta-analyses, systematic reviews and trials in people, newest first.
- Effects and clinical significance of GnRH antagonist administration for IUI timing in FSH superovulated cycles: a meta-analysis.
Fertility and sterility · October 23, 2007 · Meta-analysis · cited 42 times · open access
PMID 17936285 · DOI 10.1016/j.fertnstert.2007.06.064 · Reviews and meta-analyses
- GnRH-antagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysis.
Reproductive biomedicine online · November 1, 2006 · Meta-analysis · cited 158 times · open access
PMID 17169171 · DOI 10.1016/s1472-6483(10)60652-9 · Reviews and meta-analyses
- Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis.
Human reproduction update · August 18, 2006 · Meta-analysis · cited 306 times
PMID 16920869 · DOI 10.1093/humupd/dml038 · Reviews and meta-analyses
- Gonadotrophin-releasing hormone antagonists for assisted conception.
The Cochrane database of systematic reviews · July 19, 2006 · Meta-analysis · cited 247 times
PMID 16855976 · DOI 10.1002/14651858.cd001750.pub2 · Reviews and meta-analyses
- Safety aspects of gonadotrophin-releasing hormone antagonists in ovarian stimulation procedures: ovarian hyperstimulation syndrome and health of children born.
Reproductive biomedicine online · January 1, 2002 · Meta-analysis · cited 12 times
PMID 12537784 · DOI 10.1016/s1472-6483(11)60219-8 · Reviews and meta-analyses
- Use of GnRH antagonists in ovarian stimulation for assisted reproductive technologies compared to the long protocol. Meta-analysis.
Archives of gynecology and obstetrics · November 1, 2001 · Meta-analysis · cited 153 times
PMID 11789740 · DOI 10.1007/s00404-001-0267-2 · Reviews and meta-analyses
- Practical guidance for use of oral semaglutide in primary care: a narrative review.
Postgraduate medicine · July 9, 2020 · Systematic review · cited 14 times · open access
PMID 32643514 · DOI 10.1080/00325481.2020.1788340 · Reviews and meta-analyses
- Gonadotrophin-releasing hormone antagonists for assisted conception.
The Cochrane database of systematic reviews · January 1, 2001 · Systematic review · cited 67 times
PMID 11687120 · DOI 10.1002/14651858.cd001750 · Reviews and meta-analyses
- Correlation of LH level and steroid concentrations in GnRH antagonist protocol: A sub-analysis of Ganirelix phase III study of China.
Journal of gynecology obstetrics and human reproduction · March 19, 2022 · Randomized controlled trial · cited 3 times
PMID 35318120 · DOI 10.1016/j.jogoh.2022.102363 · Human clinical research
- Efficacy and safety of newly developed ganirelix acetate in infertile women for assisted reproductive technology: a prospective, randomised, controlled study.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · March 7, 2022 · Randomized controlled trial · cited 2 times
PMID 35254199 · DOI 10.1080/01443615.2022.2036955 · Human clinical research
Most cited
By OpenAlex citation count. Citations measure attention, not quality or correctness.
- The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study.
Fertility and sterility · April 26, 2007 · Randomized controlled trial · cited 422 times · open access
PMID 17462639 · DOI 10.1016/j.fertnstert.2007.02.002 · Human clinical research
- Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: results of a controlled, randomized, multicentre trial. The European Orgalutran Study Group.
Human reproduction (Oxford, England) · July 1, 2000 · Randomized controlled trial · cited 377 times · open access
PMID 10875855 · DOI 10.1093/humrep/15.7.1490 · Human clinical research
- Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization.
The Journal of clinical endocrinology and metabolism · February 1, 2002 · Randomized controlled trial · cited 343 times · open access
PMID 11836309 · DOI 10.1210/jcem.87.2.8197 · Human clinical research
- Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis.
Human reproduction update · August 18, 2006 · Meta-analysis · cited 306 times
PMID 16920869 · DOI 10.1093/humupd/dml038 · Reviews and meta-analyses
- A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle stimulating hormone (Puregon). The ganirelix dose-finding study group.
Human reproduction (Oxford, England) · November 1, 1998 · Randomized controlled trial · cited 294 times
PMID 9853849 · DOI 10.1093/humrep/13.11.3023 · Human clinical research
Latest publications
- GnRH-receptor antagonism as a targeted approach to reproductive dysfunction in polycystic ovary syndrome.
EBioMedicine · July 17, 2026 · Other clinical trial · cited 1 times · open access
PMID 42468113 · DOI 10.1016/j.ebiom.2026.106398 · Human clinical research
- GnRH Agonists and Antagonists in IVF/ICSI Cycles of PCOS Women: A Network Meta-Analysis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP · May 1, 2026 · Review · cited 0 times · open access
PMID 42152207 · DOI 10.29271/jcpsp.2026.05.654 · Reviews and meta-analyses
- Real-World Safety and Effectiveness of Ganirelix for Ovarian Stimulation in Chinese Women: A Multicenter, Prospective, Single-Arm, Observational Study.
Women's health reports (New Rochelle, N.Y.) · October 9, 2025 · Observational human study · cited 0 times · open access
PMID 41142490 · DOI 10.1177/26884844251387017 · Human clinical research
- Post-marketing safety profile of ganirelix in women: a 20-year pharmacovigilance analysis of global adverse drug event databases (2004-2024).
BMC pharmacology & toxicology · April 22, 2025 · Observational human study · cited 3 times · open access
PMID 40264185 · DOI 10.1186/s40360-025-00920-4 · Human clinical research
- Comparison of pregnancy outcomes and safety between cetrorelix and ganirelix in IVF/ICSI antagonist protocols: a retrospective cohort study.
Frontiers in reproductive health · April 14, 2025 · Observational human study · cited 1 times · open access
PMID 40297130 · DOI 10.3389/frph.2025.1492441 · Human clinical research
- Reduction in minipubertal gonadotropin levels alters reproductive lifespan and ovarian follicular loss in female mice.
Human reproduction (Oxford, England) · April 1, 2025 · Animal study · cited 8 times · open access
PMID 39948193 · DOI 10.1093/humrep/deaf019 · Animal studies
- Elagolix Represents a Less Invasive and Cheaper Option Than Injectable GnRH Antagonist for Ovulation Suppression in IVF.
The Journal of clinical endocrinology and metabolism · January 1, 2025 · Observational human study · cited 4 times · open access
PMID 38482566 · DOI 10.1210/clinem/dgae168 · Human clinical research
- GnRH Peptide Antagonist: Comparative Analysis of Chemistry and Formulation with Implications for Clinical Safety and Efficacy.
Pharmaceuticals (Basel, Switzerland) · December 31, 2024 · Review · cited 18 times · open access
PMID 39861098 · DOI 10.3390/ph18010036 · Reviews and meta-analyses
- Two livebirths achieved in cases of hypergonadotropic hypogonadism nonobstructive azoospermia, treated with GnRH agonist and gonadotrophins: a case series and review of the literature.
JBRA assisted reproduction · August 26, 2024 · Case report · cited 0 times · open access
PMID 38875134 · DOI 10.5935/1518-0557.20240039 · Human clinical research
- The role of elagolix in ovulation suppression during controlled ovarian stimulation: a retrospective cohort study.
F&S reports · July 4, 2024 · Observational human study · cited 5 times · open access
PMID 39781082 · DOI 10.1016/j.xfre.2024.06.006 · Human clinical research
How this is counted
PubMed records matched by the names below, counted when the peptide is in the title, indexed by MeSH, or confirmed from the abstract. The exact query can be rerun on Europe PMC. Methodology
Search terms: Antagon; Fyremadel; Ganirelix; Ganirelixum; Orgalutran
((TITLE_ABS:"Antagon" OR CHEM:"Antagon") OR (TITLE_ABS:"Fyremadel" OR CHEM:"Fyremadel") OR (TITLE_ABS:"Ganirelix" OR CHEM:"Ganirelix") OR (TITLE_ABS:"Ganirelixum" OR CHEM:"Ganirelixum") OR (TITLE_ABS:"Orgalutran" OR CHEM:"Orgalutran")) AND SRC:MED
Cite this page
Peptide Library. (2026, November 2). Ganirelix research statistics (Version weekly-2026-11-01) [Statistic]. Peptide Library. https://peptidelibrary.app/research/peptides/ganirelix